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Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis
dc.contributor.authorMatsukawa, Akihiro
dc.contributor.authorKudoh, Shinji
dc.contributor.authorSano, Gen‐ichiro
dc.contributor.authorMaeda, Takako
dc.contributor.authorIto, Takaaki
dc.contributor.authorLukacs, Nicholas W.
dc.contributor.authorHogaboam, Cory M.
dc.contributor.authorKunkel, Steven L.
dc.contributor.authorLira, Sergio A.
dc.date.accessioned2020-03-17T18:32:57Z
dc.date.available2020-03-17T18:32:57Z
dc.date.issued2006-02
dc.identifier.citationMatsukawa, Akihiro; Kudoh, Shinji; Sano, Gen‐ichiro ; Maeda, Takako; Ito, Takaaki; Lukacs, Nicholas W.; Hogaboam, Cory M.; Kunkel, Steven L.; Lira, Sergio A. (2006). "Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis." The FASEB Journal 20(2): 302-304.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154456
dc.description.abstractAn effective clearance of microbes is crucial in host defense during infection. In the present study, we demonstrate that CC chemokine receptor 8 (CCR8) skews innate immune response during septic peritonitis induced by cecal ligation and puncture (CLP). CCR8 was expressed in resident peritoneal macrophages and elicited leukocytes during CLP in the wildâ type CCR8+/+ mice. CCR8â /â mice were resistant to CLPâ induced lethality relative to CCR8+/+ mice, and this resistance was associated with an augmented bacterial clearance in CCR8â /â mice. In vitro, peritoneal macrophages from CCR8â /â mice, but not neutrophils, exhibited enhanced bactericidal activities relative to those from CCR8+/+ mice. Upon stimulation with the bacterial component LPS, elevated levels of superoxide generation, lysosomal enzyme release, and nitric oxide generation, effector molecules for bacterial killing were detected in CCR8â /â macrophages relative to CCR8+/+ macrophages. In addition, CCR8â /â macrophages produced significantly higher levels than CCR8+/+ macrophages of several cytokines and chemokines known to augment bactericidal activities of leukocytes that include TNFâ α, ILâ 12, macrophageâ derived chemokine (MDC/CCL22), macrophage inflammatory protein (MIP)â 2, and KC. Altogether, these results indicate that CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity.
dc.publisherWiley Periodicals, Inc.
dc.publisherFederation of American Societies for Experimental Biology
dc.subject.othersepsis
dc.subject.otherinflammation
dc.subject.othercytokines
dc.subject.othermacrophages
dc.titleAbsence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154456/1/fsb2fj041728fje.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154456/2/fsb2fj041728fje-sup-0001.pdf
dc.identifier.doi10.1096/fj.04-1728fje
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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