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Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis
dc.contributor.authorGumucio, Jonathan P.
dc.contributor.authorQasawa, Austin H.
dc.contributor.authorFerrara, Patrick J.
dc.contributor.authorMalik, Afshan N.
dc.contributor.authorFunai, Katsuhiko
dc.contributor.authorMcdonagh, Brian
dc.contributor.authorMendias, Christopher L.
dc.date.accessioned2020-03-17T18:33:53Z
dc.date.availableWITHHELD_5_MONTHS
dc.date.available2020-03-17T18:33:53Z
dc.date.issued2019-07
dc.identifier.citationGumucio, Jonathan P.; Qasawa, Austin H.; Ferrara, Patrick J.; Malik, Afshan N.; Funai, Katsuhiko; Mcdonagh, Brian; Mendias, Christopher L. (2019). "Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis." The FASEB Journal 33(7): 7863-7881.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154491
dc.description.abstractMyosteatosis is the pathologic accumulation of lipid that can occur in conjunction with atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many clinical studies have demonstrated that the degree of lipid infiltration negatively correlates with muscle function and regeneration. Our objective was to determine the pathologic changes that result in lipid accumulation in injured muscle fibers. We used a rat model of rotator cuff injury in this study because the rotator cuff muscle group is particularly prone to the development of myosteatosis after injury. Muscles were collected from uninjured controls or 10, 30, or 60 d after injury and analyzed using a combination of muscle fiber contractility assessments, RNA sequencing, and undirected metabolomics, lipidomics, and proteomics, along with bioinformatics techniques to identify potential pathways and cellular processes that are dysregulated after rotator cuff tear. Bioinformatics analyses indicated that mitochondrial function was likely disrupted after injury. Based on these findings and given the role that mitochondria play in lipid metabolism, we then performed targeted biochemical and imaging studies and determined that mitochondrial dysfunction and reduced fatty acid oxidation likely leads to the accumulation of lipid in myosteatosis.—Gumucio, J. P., Qasawa, A. H., Ferrara, P. J., Malik, A. N., Funai, K., McDonagh, B., Mendias, C. L. Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J. 33, 7863–7881 (2019). www.fasebj.org
dc.publisherFederation of American Societies for Experimental Biology
dc.publisherWiley Periodicals, Inc.
dc.subject.otherfatty degeneration
dc.subject.otherrotator cuff
dc.subject.othermuscle injury
dc.subject.othermuscle atrophy
dc.titleReduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154491/1/fsb2fj201802457rr.pdf
dc.identifier.doi10.1096/fj.201802457RR
dc.identifier.sourceThe FASEB Journal
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