Distinctive immunoregulatory effects of adenosine on T cells of older humans
dc.contributor.author | Hesdorffer, Charles S. | |
dc.contributor.author | Malchinkhuu, Enkhzol | |
dc.contributor.author | Biragyn, Arya | |
dc.contributor.author | Mabrouk, Omar S. | |
dc.contributor.author | Kennedy, Robert T. | |
dc.contributor.author | Madara, Karen | |
dc.contributor.author | Taub, Dennis D. | |
dc.contributor.author | Longo, Dan L. | |
dc.contributor.author | Schwartz, Janice B. | |
dc.contributor.author | Ferrucci, Luigi | |
dc.contributor.author | Goetzl, Edward J. | |
dc.date.accessioned | 2020-03-17T18:34:58Z | |
dc.date.available | 2020-03-17T18:34:58Z | |
dc.date.issued | 2012-03 | |
dc.identifier.citation | Hesdorffer, Charles S.; Malchinkhuu, Enkhzol; Biragyn, Arya; Mabrouk, Omar S.; Kennedy, Robert T.; Madara, Karen; Taub, Dennis D.; Longo, Dan L.; Schwartz, Janice B.; Ferrucci, Luigi; Goetzl, Edward J. (2012). "Distinctive immunoregulatory effects of adenosine on T cells of older humans." The FASEB Journal 26(3): 1301-1310. | |
dc.identifier.issn | 0892-6638 | |
dc.identifier.issn | 1530-6860 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/154518 | |
dc.publisher | Federation of American Societies for Experimental Biology | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | cytokines | |
dc.subject.other | cellular antigens | |
dc.subject.other | chemotaxis | |
dc.subject.other | immunodeficiency | |
dc.subject.other | immunosenescence | |
dc.title | Distinctive immunoregulatory effects of adenosine on T cells of older humans | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Biology | |
dc.subject.hlbtoplevel | Science | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/154518/1/fsb2026003033.pdf | |
dc.identifier.doi | 10.1096/fj.11-197046 | |
dc.identifier.source | The FASEB Journal | |
dc.identifier.citedreference | Huang, M. C., Greig, N. H., Luo, W., Tweedie, D., Schwartz, J. B., Longo, D. L., Ferrucci, L., Ershler, W. B., and Goetzl, E. J. ( 2011 ) Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. Clin. Immunol. 138, 201 – 211 | |
dc.identifier.citedreference | Resta, R., Yamashita, Y., and Thompson, L. F. ( 1998 ) Ectoenzyme and signaling functions of lymphocyte CD73. Immunol. Rev. 161, 95 – 109 | |
dc.identifier.citedreference | Borsellino, G., Kleinewietfeld, M., Di Mitri, D., Sternjak, A., Diamantini, A., Giometto, R., Hopner, S., Centonze, D., Bernardi, G., Dell’Acqua, M. L., Rossini, P. M., Battistini, L., Rotzschke, O., and Falk, K. ( 2007 ) Expression of ectonucleoti‐dase CD39 byFoxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110, 1225 – 1232 | |
dc.identifier.citedreference | Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D., Usheva, A., Erat, A., Chen, J. F., Enjyoji, K., Linden, J., Oukka, M., Kuchroo, V. K., Strom, T. B., and Robson, S. C. ( 2007 ) Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257 – 1265 | |
dc.identifier.citedreference | Zhou, Q., Yan, J., Putheti, P., Wu, Y., Sun, X., Toxavidis, V., Tigges, J., Kassam, N., Enjyoji, K., Robson, S. C., Strom, T. B., and Gao, W. ( 2009 ) Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations. Am. J. Transplant. 9, 2303 – 2311 | |
dc.identifier.citedreference | Airas, L., Niemela, J., Salmi, M., Puurunen, T., Smith, D. J., and Jalkanen, S. ( 1997 ) Differential regulation and function of CD73, a glycosyl‐phosphatidylinositol‐linked 70‐kD adhesion molecule, on lymphocytes and endothelial cells. J. Cell Biol. 136, 421 – 431 | |
dc.identifier.citedreference | Takedachi, M., Qu, D., Ebisuno, Y., Oohara, H., Joachims, M. L., McGee, S. T., Maeda, E., McEver, R. P., Tanaka, T., Miyasaka, M., Murakami, S., Krahn, T., Blackburn, M. R., and Thompson, L. F. ( 2008 ) CD73‐generated adenosine restricts lymphocyte migration into draining lymph nodes. J. Immunol. 180, 6288 – 6296 | |
dc.identifier.citedreference | Algars, A., Karikoski, M., Yegutkin, G. G., Stoitzner, P., Niemela, J., Salmi, M., and Jalkanen, S. ( 2011 ) Different role of CD73 in leukocyte trafficking via blood and lymph vessels. Blood 117, 4387 – 4393 | |
dc.identifier.citedreference | Blay, J., White, T. D., and Hoskin, D. W. ( 1997 ) The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res. 57, 2602 – 2605 | |
dc.identifier.citedreference | Dos Reis, G. A., Nobrega, A. F., and de Carvalho, R. P. ( 1986 ) Purinergic modulation of T‐lymphocyte activation: differential susceptibility of distinct activation steps and correlation with intracellular 3′,5′‐cyclic adenosine monophosphate accumulation. Cell. Immunol. 101, 213 – 231 | |
dc.identifier.citedreference | Butler, J. J., Mader, J. S., Watson, C. L., Zhang, H., Blay, J., and Hoskin, D. W. ( 2003 ) Adenosine inhibits activation‐induced T cell expression of CD2 and CD28 co‐stimulatory molecules: role of interleukin‐2 and cyclic AMP signaling pathways. J. Cell. Biochem. 89, 975 – 991 | |
dc.identifier.citedreference | Gessi, S., Varani, K., Merighi, S., Fogli, E., Sacchetto, V., Benini, A., Leung, E., Mac‐Lennan, S., and Borea, P. A. ( 2007 ) Adenosine and lymphocyte regulation. Purinergic Signal. 3, 109 – 116 | |
dc.identifier.citedreference | Parish, S. T., Kim, S., Sekhon, R. K., Wu, J. E., Kawakatsu, Y., and Effros, R. B. ( 2010 ) Adenosine deaminase modulation of telomerase activity and replicative senescence in human CD8 T lymphocytes. J. Immunol. 184, 2847 – 2854 | |
dc.identifier.citedreference | Hoskin, D. W., Mader, J. S., Furlong, S. J., Conrad, D. M., and Blay, J. ( 2008 ) Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells [Review]. Intl. J. Oncol. 32, 527 – 535 | |
dc.identifier.citedreference | Ernst, P. B., Garrison, J. C., and Thompson, L. F. ( 2010 ) Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology. J. Immunol. 185, 1993 – 1998 | |
dc.identifier.citedreference | Himer, L., Csoka, B., Selmeczy, Z., Koscso, B., Pocza, T., Pacher, P., Nemeth, Z. H., Deitch, E. A., Vizi, E. S., Cronstein, B. N., and Hasko, G. ( 2010 ) Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation‐induced cell death. FASEB J. 24, 2631 – 2640 | |
dc.identifier.citedreference | Zheng, Y., Voice, J. K., Kong, Y., and Goetzl, E. J. ( 2000 ) Altered expression and functional profile of lysophosphatidic acid receptors in mitogen‐activated human blood T lymphocytes. FASEB J. 14, 2387 – 2389 | |
dc.identifier.citedreference | Olkhanud, P. B., Damdinsuren, B., Bodogai, M., Gress, R. E., Sen, R., Wejksza, K., Malchinkhuu, E., Wersto, R. P., and Biragyn, A. ( 2011 ) Tumor‐evoked regulatory B cells promote breast cancer metastasis by converting resting CD4 T cells to T‐regulatory cells. Cancer Res. 71, 3505 – 3515 | |
dc.identifier.citedreference | Graler, M. H., Huang, M. C., Watson, S., and Goetzl, E. J. ( 2005 ) Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1‐phosphate receptor by mouse lymphocytes. J. Immunol. 174, 1997 – 2003 | |
dc.identifier.citedreference | Gillis, S., Kozak, R., Durante, M., and Weksler, M. E. ( 1981 ) Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J. Clin. Invest. 67, 937 – 942 | |
dc.identifier.citedreference | Rea, I. M., Stewart, M., Campbell, P., Alexander, H. D., Crockard, A. D., and Morris, T. C. ( 1996 ) Changes in lymphocyte subsets, interleukin 2, and soluble interleukin 2 receptor in old and very old age. Gerontology 42, 69 – 78 | |
dc.identifier.citedreference | Caruso, C., Candore, G., Cigna, D., Di Lorenzo, G., Sireci, G., Dieli, F., and Salerno, A. ( 1996 ) Cytokine production pathway in the elderly. Immunol. Res. 15, 84 – 90 | |
dc.identifier.citedreference | Weng, N. P., Akbar, A. N., and Goronzy, J. ( 2009 ) CD28 ‐ T cells: their role in the age‐associated decline of immune function. Trends Immunol. 30, 306 – 312 | |
dc.identifier.citedreference | Kase, H., Richardson, P. and Jenner, P., eds ( 1999 ) Adenosine Receptors and Parkinson’s Disease, Academic Press, New York | |
dc.identifier.citedreference | El Yacoubi, M., Ledent, C., Parmentier, M., Bertorelli, R., Ongini, E., Costentin, J., and Vaugeois, J. M. ( 2001 ) Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. Brit. J. Pharmacol. 134, 68 – 77 | |
dc.identifier.citedreference | Shook, B. C., Rassnick, S., Osborne, M. C., Davis, S., Westover, L., Boulet, J., Hall, D., Rupert, K. C., Heintzelman, G. R., Hansen, K., Chakravarty, D., Bullington, J. L., Russell, R., Branum, S., Wells, K. M., Damon, S., Youells, S., Li, X., Beauchamp, D. A., Palmer, D., Reyes, M., Demarest, K., Tang, Y., Rhodes, K., and Jackson, P. F. ( 2010 ) In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson’s disease. J. Med. Chem. 53, 8104 – 8115 | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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