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Miro: A molecular switch at the center of mitochondrial regulation
dc.contributor.authorEberhardt, Emily L.
dc.contributor.authorLudlam, Anthony V.
dc.contributor.authorTan, Zhenyu
dc.contributor.authorCianfrocco, Michael A.
dc.date.accessioned2020-06-03T15:22:41Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-06-03T15:22:41Z
dc.date.issued2020-06
dc.identifier.citationEberhardt, Emily L.; Ludlam, Anthony V.; Tan, Zhenyu; Cianfrocco, Michael A. (2020). "Miro: A molecular switch at the center of mitochondrial regulation." Protein Science 29(6): 1269-1284.
dc.identifier.issn0961-8368
dc.identifier.issn1469-896X
dc.identifier.urihttps://hdl.handle.net/2027.42/155476
dc.description.abstractThe orchestration of mitochondria within the cell represents a critical aspect of cell biology. At the center of this process is the outer mitochondrial membrane protein, Miro. Miro coordinates diverse cellular processes by regulating connections between organelles and the cytoskeleton that range from mediating contacts between the endoplasmic reticulum and mitochondria to the regulation of both actin and microtubule motor proteins. Recently, a number of cell biological, biochemical, and protein structure studies have helped to characterize the myriad roles played by Miro. In addition to answering questions regarding Miro’s function, these studies have opened the door to new avenues in the study of Miro in the cell. This review will focus on summarizing recent findings for Miro’s structure, function, and activity while highlighting key questions that remain unanswered.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otherneurodegeneration
dc.subject.otherorganelle contact sites
dc.subject.otherGTPase
dc.subject.othermicrotubule transport
dc.subject.otherMiro
dc.subject.othermitochondria
dc.titleMiro: A molecular switch at the center of mitochondrial regulation
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155476/1/pro3839.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155476/2/pro3839_am.pdf
dc.identifier.doi10.1002/pro.3839
dc.identifier.sourceProtein Science
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