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Restless legs syndrome and health‐related quality of life in adults with multiple sclerosis
dc.contributor.authorCederberg, Katie L. J.
dc.contributor.authorJeng, Brenda
dc.contributor.authorSasaki, Jeffer E.
dc.contributor.authorBraley, Tiffany J.
dc.contributor.authorWalters, Arthur S.
dc.contributor.authorMotl, Robert W.
dc.date.accessioned2020-06-03T15:23:00Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-06-03T15:23:00Z
dc.date.issued2020-06
dc.identifier.citationCederberg, Katie L. J.; Jeng, Brenda; Sasaki, Jeffer E.; Braley, Tiffany J.; Walters, Arthur S.; Motl, Robert W. (2020). "Restless legs syndrome and health‐related quality of life in adults with multiple sclerosis." Journal of Sleep Research 29(3): n/a-n/a.
dc.identifier.issn0962-1105
dc.identifier.issn1365-2869
dc.identifier.urihttps://hdl.handle.net/2027.42/155491
dc.description.abstractRestless legs syndrome (RLS) is a sleep disorder that may exacerbate many of the symptoms and consequences of multiple sclerosis (MS), and may have further implications for health‐related quality of life (HRQOL). The present study examined the relationships among RLS, symptoms and HRQOL in people with MS. Participants with MS (n = 275) completed the Cambridge‐Hopkins Restless Legs Syndrome Questionnaire, the International Restless Legs Syndrome Study Group Scale, the Multiple Sclerosis Impact Scale, the Pittsburgh Sleep Quality Index, the Fatigue Severity Scale, the Hospital Anxiety and Depression Scale and the Patient Determined Disease Steps. There were 74 (26.9%) persons with MS who had RLS (MS + RLS). The MS + RLS group reported worse physical and psychological HRQOL (p = 0.020 and p = 0.017, respectively) and greater perceived fatigue (p = 0.006) and anxiety symptoms (p = 0.042) than the MS‐only group. Within the MS + RLS group, RLS severity was associated with physical (r = 0.43) and psychological (r = 0.46) HRQOL, sleep quality (r = 0.38), perceived fatigue (r = 0.28), depression (r = 0.38) and anxiety (r = 0.28). The relationships between RLS severity and the domains of HRQOL were attenuated when accounting for fatigue, depression and/or anxiety. Worse RLS severity was associated with reduced HRQOL, which was accounted for by fatigue, depression and anxiety.
dc.publisherNJ
dc.publisherWiley Periodicals, Inc.
dc.subject.otheranxiety
dc.subject.otherdepression
dc.subject.otherrestless legs syndrome
dc.subject.othermultiple sclerosis
dc.subject.otherhealth‐related quality of life
dc.subject.otherfatigue
dc.titleRestless legs syndrome and health‐related quality of life in adults with multiple sclerosis
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155491/1/jsr12880.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155491/2/jsr12880_am.pdf
dc.identifier.doi10.1111/jsr.12880
dc.identifier.sourceJournal of Sleep Research
dc.identifier.citedreferenceMoreira, N. C. V., Damasceno, R. S., Medeiros, C. A. M., De Bruin, P. F. C., Teixeira, C. A. C., Horta, W. G., & De Bruin, V. M. S. ( 2008 ). Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients. Brazilian Journal of Medical and Biological Research, 41, 932 – 937. https://doi.org/10.1590/s0100-879x2008001000017
dc.identifier.citedreferenceCohen, J. ( 1988 ). Statistical power analysis for the behavioral sciences. Lawrence Earlbaum Associates (pp. 20 – 26 ). Hillsdale: NJ.
dc.identifier.citedreferenceFruehwald, S., Loeffler‐Stastka, H., Eher, R., Saletu, B., & Baumhackl, U. ( 2001 ). Depression and quality of life in multiple sclerosis. Acta Neurologica Scandinavica, 104, 257 – 261. https://doi.org/10.1034/j.1600-0404.2001.00022.x
dc.identifier.citedreferenceGiannaki, C. D., Aristotelous, P., Stefanakis, M., Hadjigeorgiou, G. M., Manconi, M., Leonidou, E., … Pantzaris, M. ( 2018 ). Restless legs syndrome in multiple sclerosis patients: A contributing factor for fatigue, impaired functional capacity, and diminished health‐related quality of life. Neurological Research, 40 ( 7 ), 586 – 592.
dc.identifier.citedreferenceHobart, J., Lamping, D., Fitzpatrick, R., Riazi, A., & Thompson, A. ( 2001 ). The Multiple sclerosis impact scale (MSIS-29): A new patient-based outcome measure. Brain, 124 ( Pt 5 ), 962 – 973.
dc.identifier.citedreferenceHohol, M. J., Orav, E. J., & Weiner, H. L. ( 1995 ). Disease steps in multiple sclerosis: A simple approach to evaluate disease progression. Neurology, 45, 251 – 255. https://doi.org/10.1212/wnl.45.2.251
dc.identifier.citedreferenceHohol, M. J., Orav, E. J., & Weiner, H. L. ( 1999 ). Disease steps in multiple sclerosis: A longitudinal study comparing disease steps and EDSS to evaluate disease progression. Multiple Sclerosis Journal, 5, 349 – 354. https://doi.org/10.1177/135245859900500508
dc.identifier.citedreferenceKotterba, S., Neusser, T., Norenberg, C., Bussfeld, P., Glaser, T., Dörner, M., & Schürks, M. ( 2018 ). Sleep quality, daytime sleepiness, fatigue, and quality of life in patients with multiple sclerosis treated with interferon beta‐1b: Results from a prospective observational cohort study. BMC Neurology, 18, 123. https://doi.org/10.1186/s12883-018-1113-5
dc.identifier.citedreferenceKrupp, L. B., Larocca, N. G., Muir‐Nash, J., & Steinberg, A. D. ( 1989 ). The fatigue severity scale: Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology, 46, 1121 – 1123. https://doi.org/10.1001/archneur.1989.00520460115022
dc.identifier.citedreferenceLearmonth, Y. C., Hubbard, E. A., Mcauley, E., & Motl, R. W. ( 2014 ). Psychometric properties of quality of life and health‐related quality of life assessments in people with multiple sclerosis. Quality of Life Research, 23, 2015 – 2023. https://doi.org/10.1007/s11136-014-0639-2
dc.identifier.citedreferenceLearmonth, Y. C., Motl, R. W., Sandroff, B. M., Pula, J. H., & Cadavid, D. ( 2013 ). Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis. BMC Neurology, 13, 37. https://doi.org/10.1186/1471-2377-13-37
dc.identifier.citedreferenceLobentanz, I. S., Asenbaum, S., Vass, K., Sauter, C., Klösch, G., Kollegger, H., … Zeitlhofer, J. ( 2004 ). Factors influencing quality of life in multiple sclerosis patients: Disability, depressive mood, fatigue and sleep quality. Acta Neurologica Scandinavica, 110, 6 – 13. https://doi.org/10.1111/j.1600-0404.2004.00257.x
dc.identifier.citedreferenceLunde, H. M. B., Aae, T. F., Indrevåg, W., Aarseth, J., Bjorvatn, B., Myhr, K. M., & Bø, L. ( 2012 ). Poor sleep in patients with multiple sclerosis. PLoS ONE, 7, e49996. https://doi.org/10.1371/journal.pone.0049996
dc.identifier.citedreferenceManconi, M., Fabbrini, M., Bonanni, E., Filippi, M., Rocca, M., Murri, L., Ferini‐Strambi, L. ( 2007 ). High prevalence of restless legs syndrome in multiple sclerosis. European Journal of Neurology, 14, 534 – 539. https://doi.org/10.1111/j.1468-1331.2007.01740.x
dc.identifier.citedreferenceManconi, M., Ferini‐Strambi, L., Filippi, M., Bonanni, E., Iudice, A., … Terzano, G. ( 2008 ). Multicenter case‐control study on restless legs syndrome in multiple sclerosis: The REMS study. Sleep, 31, 944 – 952.
dc.identifier.citedreferenceMarrie, R. A., Zhang, L., Lix, L. M., Graff, L. A., Walker, J. R., Fisk, J. D., … El‐Gabalawy, R. ( 2018 ). The validity and reliability of screening measures for depression and anxiety disorders in multiple sclerosis. Multiple Sclerosis and Related Disorders, 20, 9 – 15. https://doi.org/10.1016/j.msard.2017.12.007
dc.identifier.citedreferenceMultiple Sclerosis International Federation. ( 2013 ) Atlas of MS: Mapping multiple sclerosis around the world. Available at: https://www.msif.org/wp-content/uploads/2014/09/Atlas-of-MS.pdf. Accessed: October 24, 2018
dc.identifier.citedreferenceNational Institute of Mental Health. ( 2018 ) National Institute of Mental Health: Anxiety Disorders. Retrieved on: October 23, 2018. Available at: https://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml
dc.identifier.citedreferenceNourbakhsh, B., Julian, L., & Waubant, E. ( 2016 ). Fatigue and depression predict quality of life in patients with early multiple sclerosis: A longitudinal study. European Journal of Neurology, 23, 1482 – 1486. https://doi.org/10.1111/ene.13102
dc.identifier.citedreferenceOhayon, M. M., O’hara, R., & Vitiello, M. V. ( 2012 ). Epidemiology of restless legs syndrome: A synthesis of the literature. Sleep Medicine Reviews, 16, 283 – 295. https://doi.org/10.1016/j.smrv.2011.05.002
dc.identifier.citedreferencePatriquin, M. A., & Mathew, S. J. ( 2017 ). The neurobiological mechanisms of generalized anxiety disorder and chronic stress. Chronic Stress, 1, [Epub ahead of print]. https://doi.org/10.1177/2470547017703993
dc.identifier.citedreferenceRestless Legs Syndrome Foundation. ( 2018 ). Medications. Available at: https://www.rls.org. Accessed: May 28, 2018.
dc.identifier.citedreferenceSieminski, M., Losy, J., & Partinen, M. ( 2015 ). Restless legs syndrome in multiple sclerosis. Sleep Medicine Reviews, 22, 15 – 22. https://doi.org/10.1016/j.smrv.2014.10.002
dc.identifier.citedreferenceTabrizi, F. M., & Radfar, M. ( 2015 ). Fatigue, sleep quality, and disability in relation to quality of life in multiple sclerosis. International Journal of MS Care, 17, 268 – 274. https://doi.org/10.7224/1537-2073.2014-046
dc.identifier.citedreferenceWallin, M. T., Culpepper, W. J., Campbell, J. D., Nelson, L. M., Langer‐Gould, A., Marrie, R. A., … Buka, S. L. ( 2019 ). The prevalence of MS in the United States: A population‐based estimate using health claims data. Neurology, 92, e1029 – e1040. https://doi.org/10.1212/wnl.0000000000007035
dc.identifier.citedreferenceWalters, A. S., LeBrocq, C., Dhar, A., Hening, W., Rosen, R., Allen, R. P., … International Restless Legs Syndrome Study Group. ( 2003 ). Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Medicine, 4, 121 – 132.
dc.identifier.citedreferenceZigmond, A. S., & Snaith, R. P. ( 1983 ). The hospital anxiety and depression scale. Acta Psychiatrica Scand., 67, 361 – 370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
dc.identifier.citedreferenceAbetz, L., Arbuckle, R., Allen, R. P., Garcia‐Borreguero, D., Hening, W., Walters, A. S., … Kirsch, J. M. ( 2006 ). The reliability, validity and responsiveness of the International Restless Legs Syndrome Study Group rating scale and subscales in a clinical‐trial setting. Sleep Medicine, 7, 340 – 349. https://doi.org/10.1016/j.sleep.2005.12.011
dc.identifier.citedreferenceAllen, R. P., Burchell, B. J., Macdonald, B., Hening, W. A., & Earley, C. J. ( 2009 ). Validation of the self‐completed Cambridge‐Hopkins questionnaire (CH‐RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey. Sleep Medicine, 10, 1097 – 1100. https://doi.org/10.1016/j.sleep.2008.10.007
dc.identifier.citedreferenceAmato, M. P., Ponziani, G., Rossi, F., Liedl, C. L., Stefanile, C., & Rossi, L. ( 2001 ). Quality of life in multiple sclerosis: The impact of depression, fatigue and disability. Multiple Sclerosis Journal, 7, 340 – 344. https://doi.org/10.1177/135245850100700511
dc.identifier.citedreferenceAndreasen, A. K., Stenager, E., & Dalgas, U. ( 2011 ). The effect of exercise therapy on fatigue in multiple sclerosis. Multiple Sclerosis Journal, 17, 1041 – 1054. https://doi.org/10.1177/1352458511401120
dc.identifier.citedreferenceAydar, G., Kurt, S., Karaer Unaldi, H., & Erkorkmaz, U. ( 2011 ). Restless legs syndrome in multiple sclerosis. European Neurology, 65, 302 – 306. https://doi.org/10.1159/000327315
dc.identifier.citedreferenceBenito‐Leon, J., Morales, J. M., Rivera‐Navarro, J., & Mitchell, A. ( 2003 ). A review about the impact of multiple sclerosis on health‐related quality of life. Disability and Rehabilitation, 25, 1291 – 1303. https://doi.org/10.1080/09638280310001608591
dc.identifier.citedreferenceBraley, T. J., & Chervin, R. D. ( 2015 ). A practical approach to the diagnosis and management of sleep disorders in patients with multiple sclerosis. Therapeutic Advances in Neurological Disorders, 8, 294 – 310. https://doi.org/10.1177/1756285615605698
dc.identifier.citedreferenceBuchfuhrer, M. J. ( 2012 ). Strategies for the treatment of restless legs syndrome. Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics, 9, 776 – 790. https://doi.org/10.1007/s13311-012-0139-4
dc.identifier.citedreferenceBuysse, D. J., Reynolds, C. F. 3rd, Monk, T. H., Berman, S. R., & Kupfer, D. J. ( 1989 ). The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193 – 213. https://doi.org/10.1016/0165-1781(89)90047-4
dc.identifier.citedreferenceCederberg, K. L., & Motl, R. W. ( 2016 ). Restless legs syndrome in multiple sclerosis: A call for better understanding and non‐pharmacological management. Current Trends in Neurology, 10, 65 – 73.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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