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Expanding the differential of superficial tumors with round‐cell morphology: Report of three cases of CIC‐rearranged sarcoma, a potentially under‐recognized entity
dc.contributor.authorMaloney, Nolan
dc.contributor.authorSmith, Stephen M.
dc.contributor.authorPeters, Sara B.
dc.contributor.authorBatistatou, Anna
dc.contributor.authorEvangelou, Zoi
dc.contributor.authorHarms, Paul W.
dc.contributor.authorChan, May P.
dc.contributor.authorAntonescu, Cristina R.
dc.contributor.authorLinos, Konstantinos
dc.date.accessioned2020-06-03T15:23:48Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-06-03T15:23:48Z
dc.date.issued2020-06
dc.identifier.citationMaloney, Nolan; Smith, Stephen M.; Peters, Sara B.; Batistatou, Anna; Evangelou, Zoi; Harms, Paul W.; Chan, May P.; Antonescu, Cristina R.; Linos, Konstantinos (2020). "Expanding the differential of superficial tumors with round‐cell morphology: Report of three cases of CIC‐rearranged sarcoma, a potentially under‐recognized entity." Journal of Cutaneous Pathology 47(6): 535-540.
dc.identifier.issn0303-6987
dc.identifier.issn1600-0560
dc.identifier.urihttps://hdl.handle.net/2027.42/155526
dc.description.abstractAmong sarcomas with a round‐cell morphology that lack rearrangement of the EWSR1 gene, rearrangements involving the CIC gene are the most common. In comparison with Ewing Sarcoma, CIC‐rearranged sarcomas present at an older average age, arise almost exclusively in soft tissues, are clinically more aggressive, and are more likely to be resistant to the chemotherapy regimens used for Ewing sarcoma. CIC‐rearranged sarcomas present more commonly in a deep location, and we suspect that superficial presentations may be under‐recognized. In this case series, we report three of such cases. Overall, the morphology is similar to CIC‐rearranged sarcomas of deeper locations. We hope to raise awareness among the dermatopathology community by expanding the differential of superficial tumors with round cell morphology.
dc.publisherWiley Periodicals, Inc.
dc.publisherBlackwell Publishing Ltd.
dc.subject.otherround‐cell sarcoma
dc.subject.otherCIC‐DUX4
dc.subject.otherCIC
dc.subject.otherCIC‐DUX
dc.subject.otherCIC‐rearranged
dc.titleExpanding the differential of superficial tumors with round‐cell morphology: Report of three cases of CIC‐rearranged sarcoma, a potentially under‐recognized entity
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDermatology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155526/1/cup13639_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155526/2/cup13639.pdf
dc.identifier.doi10.1111/cup.13639
dc.identifier.sourceJournal of Cutaneous Pathology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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