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Parentage of Hydatidiform Moles
dc.contributor.authorWenk, Robert E.
dc.contributor.authorBaird, Michael
dc.contributor.authorPeterson, John
dc.contributor.authorDavis, Debra
dc.contributor.authorLieberman, Richard
dc.contributor.authorMaly, Janice M.
dc.contributor.authorCampbell, Lindsey J.
dc.contributor.authorFox, Kathy K.
dc.contributor.authorSchelling, Kristin A.
dc.date.accessioned2020-07-02T20:32:21Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-07-02T20:32:21Z
dc.date.issued2020-07
dc.identifier.citationWenk, Robert E.; Baird, Michael; Peterson, John; Davis, Debra; Lieberman, Richard; Maly, Janice M.; Campbell, Lindsey J.; Fox, Kathy K.; Schelling, Kristin A. (2020). "Parentage of Hydatidiform Moles." Journal of Forensic Sciences 65(4): 1346-1349.
dc.identifier.issn0022-1198
dc.identifier.issn1556-4029
dc.identifier.urihttps://hdl.handle.net/2027.42/155886
dc.description.abstractWe were presented with the STR (short tandem repeat) profiles from two separate paternity trios. Each trio consisted of a mother, an alleged father, and products of conception (POC) that contained a hydatidiform mole but no visible fetus. In both cases, antecedent pregnancies had followed alleged sexual assaults. Mole classification and pathogenesis are described in order to explain the analyses and statistical reasoning used in each case. One mole exhibited several loci with two different paternal alleles, indicating it was a dispermic (heterozygous) mole. Maternal decidua contaminated the POC, preventing the identification of paternal obligate alleles (POAs) at some loci. The other mole exhibited only one paternal allele/locus at all loci and no maternal alleles, indicating it was a diandric and diploid (homozygous) mole. In each case, traditional calculations were used to determine paternity indices (PIs) at loci that exhibited one paternal allele/locus. PIs at mole loci with two different paternal alleles/locus were calculated from formulas first used for child chimeras that are always dispermic. Combined paternity indices in both mole cases strongly supported the paternity of each suspect.
dc.publisherWiley Periodicals, Inc.
dc.publisherAmerican Association of Blood Banks
dc.subject.otherpaternity test
dc.subject.othergenetic kinship
dc.subject.otherdispermy
dc.subject.othermole classification
dc.subject.otherhydatidiform mole
dc.subject.otherDNA testing
dc.titleParentage of Hydatidiform Moles
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelScience (General)
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155886/1/jfo14291.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155886/2/jfo14291_am.pdf
dc.identifier.doi10.1111/1556-4029.14291
dc.identifier.sourceJournal of Forensic Sciences
dc.identifier.citedreferenceNguyen NMP, Khawajkie Y, Mechtouf N, Rezaei M, Breguet M, Kurvinen E, et al. The genetics of recurrent hydatidiform moles: lessons from a comprehensive analysis of 113 patients. Mod Pathol 2018; 31 ( 7 ): 1116 – 30.
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dc.identifier.citedreferenceGenest DR, Dorfman DM, Castrillon DH. Ploidy and imprinting in hydatidiform moles. Complementary use of flow cytometry and immunohistochemistry of the imprinted gene product p57KIP2 to assist molar classification. J Reprod Med 2002; 47 ( 5 ): 342 – 6.
dc.identifier.citedreferenceBanet N, DeScipio C, Murphy KM, Beierl K, Adams E, Vang R, et al. Characteristics of hydatidiform moles: analysis of a prospective series with p57 immunohistochemistry and molecular genotyping. Mod Pathol 2014; 27 ( 2 ): 238 – 54.
dc.identifier.citedreferenceMorris JW. Probability of paternity: logic 1. In: Silver H, editor. Probability of inclusion in paternity testing. Arlington, VA: American Association of Blood Banks, 1982; 46.
dc.identifier.citedreferenceWenk RE, Davis D. Paternity probabilities when a child is a congenital chimera. Transfusion 2017; 57 ( 11 ): 2814 – 5.
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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