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High‐level induction of fetal haemoglobin by pomalidomide in β‐thalassaemia/HbE erythroid progenitor cells

dc.contributor.authorKhamphikham, Pinyaphat
dc.contributor.authorNualkaew, Tiwaporn
dc.contributor.authorPongpaksupasin, Phitchapa
dc.contributor.authorKaewsakulthong, Woratree
dc.contributor.authorSongdej, Duantida
dc.contributor.authorPaiboonsukwong, Kittiphong
dc.contributor.authorEngel, James D.
dc.contributor.authorHongeng, Suradej
dc.contributor.authorFucharoen, Suthat
dc.contributor.authorSripichai, Orapan
dc.contributor.authorJearawiriyapaisarn, Natee
dc.date.accessioned2020-07-02T20:33:37Z
dc.date.availableWITHHELD_12_MONTHS
dc.date.available2020-07-02T20:33:37Z
dc.date.issued2020-06
dc.identifier.citationKhamphikham, Pinyaphat; Nualkaew, Tiwaporn; Pongpaksupasin, Phitchapa; Kaewsakulthong, Woratree; Songdej, Duantida; Paiboonsukwong, Kittiphong; Engel, James D.; Hongeng, Suradej; Fucharoen, Suthat; Sripichai, Orapan; Jearawiriyapaisarn, Natee (2020). "High‐level induction of fetal haemoglobin by pomalidomide in β‐thalassaemia/HbE erythroid progenitor cells." British Journal of Haematology 189(6): e240-e245.
dc.identifier.issn0007-1048
dc.identifier.issn1365-2141
dc.identifier.urihttps://hdl.handle.net/2027.42/155942
dc.publisherWiley Periodicals, Inc.
dc.subject.otherfetal haemoglobin induction
dc.subject.otherβ-thalassaemia/HbE
dc.subject.otherpomalidomide
dc.subject.otherhydroxyurea
dc.subject.otherdecitabine
dc.titleHigh‐level induction of fetal haemoglobin by pomalidomide in β‐thalassaemia/HbE erythroid progenitor cells
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOncology and Hematology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155942/1/bjh16670.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155942/2/bjh16670_am.pdf
dc.identifier.doi10.1111/bjh.16670
dc.identifier.sourceBritish Journal of Haematology
dc.identifier.citedreferenceUda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, et al. Genome‐wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta‐thalassemia. Proc Natl Acad Sci USA. 2008; 105: 1620 – 5.
dc.identifier.citedreferenceMusallam KM, Taher AT, Cappellini MD, Sankaran VG. Clinical experience with fetal hemoglobin induction therapy in patients with beta‐thalassemia. Blood. 2013; 121: 2199 – 212; quiz 2372.
dc.identifier.citedreferenceLey TJ, DeSimone J, Anagnou NP, Keller GH, Humphries RK, Turner PH, et al. 5‐azacytidine selectively increases gamma‐globin synthesis in a patient with beta+ thalassemia. N Engl J Med. 1982; 307: 1469 – 75.
dc.identifier.citedreferenceOlivieri, NF, Saunthararajah, Y, Thayalasuthan, V, Kwiatkowski, J, Ware, RE, Kuypers, FA, et al. A pilot study of subcutaneous decitabine in beta‐thalassemia intermedia. Blood. 2011; 118: 2708 – 11.
dc.identifier.citedreferenceFucharoen S, Siritanaratkul N, Winichagoon P, Chowthaworn J, Siriboon W, Muangsup W, et al. Hydroxyurea increases hemoglobin F levels and improves the effectiveness of erythropoiesis in beta‐thalassemia/hemoglobin E disease. Blood. 1996; 87: 887 – 92.
dc.identifier.citedreferenceCui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, et al. The LSD1 inhibitor RN‐1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015; 126: 386 – 96.
dc.identifier.citedreferenceDulmovits BM, Appiah‐Kubi AO, Papoin J, Hale J, He M, Al‐Abed Y, et al. Pomalidomide reverses gamma‐globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors. Blood. 2016; 127: 1481 – 92.
dc.identifier.citedreferenceLacy MQ, McCurdy AR. Pomalidomide. Blood. 2013; 122: 2305 – 9.
dc.identifier.citedreferenceBartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer. 2004; 4: 314 – 22.
dc.identifier.citedreferencePatthamalai P, Fuchareon S, Chaneiam N, Ghalie RG, Chui DH, Boosalis MS, et al. A phase 2 trial of HQK‐1001 in HbE‐beta thalassemia demonstrates HbF induction and reduced anemia. Blood. 2014; 123: 1956 – 7.
dc.identifier.citedreferenceFucharoen S, Inati A, Siritanaratku N, Thein SL, Wargin WC, Koussa S, et al. A randomized phase I/II trial of HQK‐1001, an oral fetal globin gene inducer, in beta‐thalassaemia intermedia and HbE/beta‐thalassaemia. Br J Haematol. 2013; 161: 587 – 93.
dc.identifier.citedreferenceShi L, Cui S, Engel JD, Tanabe O. Lysine‐specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med. 2013; 19: 291 – 4.
dc.identifier.citedreferenceNuinoon M, Makarasara W, Mushiroda T, Setianingsih I, Wahidiyat PA, Sripichai O, et al. A genome‐wide association identified the common genetic variants influence disease severity in beta0‐thalassemia/hemoglobin E. Hum Genet. 2010; 127: 303 – 14.
dc.identifier.citedreferenceSankaran VG, Orkin SH. The switch from fetal to adult hemoglobin. Cold Spring Harb Perspect Med. 2013; 3: a011643.
dc.identifier.citedreferenceMiguel JS, Weisel K, Moreau P, Lacy M, Song K, Delforge M, et al. Pomalidomide plus low‐dose dexamethasone versus high‐dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM‐003): a randomised, open‐label, phase 3 trial. Lancet Oncol. 2013; 14: 1055 – 66.
dc.identifier.citedreferenceMoutouh‐de Parseval LA, Verhelle D, Glezer E, Jensen‐Pergakes K, Ferguson GD, Corral LG, et al. Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells. J Clin Invest. 2008; 118: 248 – 58.
dc.identifier.citedreferenceMeiler SE, Wade M, Kutlar F, Yerigenahally SD, Xue Y, Moutouh‐de Parseval LA, et al. Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice. Blood. 2011; 118: 1109 – 12.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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