Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study
dc.contributor.author | Nouraie, Mehdi | |
dc.contributor.author | Darbari, Deepika S. | |
dc.contributor.author | Rana, Sohail | |
dc.contributor.author | Minniti, Caterina P. | |
dc.contributor.author | Castro, Oswaldo L. | |
dc.contributor.author | Luchtman‐jones, Lori | |
dc.contributor.author | Sable, Craig | |
dc.contributor.author | Dham, Niti | |
dc.contributor.author | Kato, Gregory J. | |
dc.contributor.author | Gladwin, Mark T. | |
dc.contributor.author | Ensing, Gregory | |
dc.contributor.author | Arteta, Manuel | |
dc.contributor.author | Campbell, Andrew | |
dc.contributor.author | Taylor, James G. | |
dc.contributor.author | Nekhai, Sergei | |
dc.contributor.author | Gordeuk, Victor R. | |
dc.date.accessioned | 2020-07-02T20:33:46Z | |
dc.date.available | WITHHELD_13_MONTHS | |
dc.date.available | 2020-07-02T20:33:46Z | |
dc.date.issued | 2020-07 | |
dc.identifier.citation | Nouraie, Mehdi; Darbari, Deepika S.; Rana, Sohail; Minniti, Caterina P.; Castro, Oswaldo L.; Luchtman‐jones, Lori ; Sable, Craig; Dham, Niti; Kato, Gregory J.; Gladwin, Mark T.; Ensing, Gregory; Arteta, Manuel; Campbell, Andrew; Taylor, James G.; Nekhai, Sergei; Gordeuk, Victor R. (2020). "Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study." American Journal of Hematology 95(7): 766-774. | |
dc.identifier.issn | 0361-8609 | |
dc.identifier.issn | 1096-8652 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/155951 | |
dc.description.abstract | In the US, mortality in sickle cell disease (SCD) increases after age 18- 20- years. Biomarkers of mortality risk can identify patients who need intensive follow- up and early or novel interventions. We prospectively enrolled 510 SCD patients aged 3- 20- years into an observational study in 2006- 2010 and followed 497 patients for a median of 88- months (range 1- 105). We hypothesized that elevated pulmonary artery systolic pressure as reflected in tricuspid regurgitation velocity (TRV) would be associated with mortality. Estimated survival to 18- years was 99% and to 25- years, 94%. Causes of death were known in seven of 10 patients: stroke in four (hemorrhagic two, infarctive one, unspecified one), multiorgan failure one, parvovirus B19 infection one, sudden death one. Baseline TRV - ¥2.7 m/second (>2 SD above the mean in age- matched and gender- matched non- SCD controls) was observed in 20.0% of patients who died vs 4.6% of those who survived (P =- .012 by the log rank test for equality of survival). The baseline variable most strongly associated with an elevated TRV was a high hemolytic rate. Additional biomarkers associated with mortality were ferritin - ¥2000- μg/L (observed in 60% of patients who died vs 7.8% of survivors, P <- .001), forced expiratory volume in 1 minute to forced vital capacity ratio (FEV1/FVC) <0.80 (71.4% of patients who died vs 18.8% of survivors, P <- .001), and neutrophil count - ¥10x109/L (30.0% of patients who died vs 7.9% of survivors, P =- .018). In SCD children, adolescents and young adults, steady- state elevations of TRV, ferritin and neutrophils and a low FEV1/FVC ratio may be biomarkers associated with increased risk of death. | |
dc.publisher | John Wiley & Sons, Inc. | |
dc.title | Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | |
dc.subject.hlbsecondlevel | Oncology and Hematology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.subject.hlbtoplevel | Science | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/155951/1/ajh25799_am.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/155951/2/ajh25799.pdf | |
dc.identifier.doi | 10.1002/ajh.25799 | |
dc.identifier.source | American Journal of Hematology | |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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