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Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function
dc.contributor.authorSchmitt, Rebecca E.
dc.contributor.authorMessick, Monica R.
dc.contributor.authorShell, Brandon C.
dc.contributor.authorDunbar, Ellyn K.
dc.contributor.authorFang, Huai‐fang
dc.contributor.authorShelton, Keith L.
dc.contributor.authorVenton, B. Jill
dc.contributor.authorPletcher, Scott D.
dc.contributor.authorGrotewiel, Mike
dc.date.accessioned2020-07-02T20:34:29Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-07-02T20:34:29Z
dc.date.issued2020-07
dc.identifier.citationSchmitt, Rebecca E.; Messick, Monica R.; Shell, Brandon C.; Dunbar, Ellyn K.; Fang, Huai‐fang ; Shelton, Keith L.; Venton, B. Jill; Pletcher, Scott D.; Grotewiel, Mike (2020). "Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function." Addiction Biology 25(4): n/a-n/a.
dc.identifier.issn1355-6215
dc.identifier.issn1369-1600
dc.identifier.urihttps://hdl.handle.net/2027.42/155987
dc.description.abstractAbuse of alcohol is a major clinical problem with far- reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol- related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila melanogaster as a model to investigate the effect of diet, an environmental factor, on ethanol sedation. Providing flies with diets high in yeast, a routinely used component of fly media, increased their resistance to ethanol sedation. The yeast- induced resistance to ethanol sedation occurred in several different genetic backgrounds, was observed in males and females, was elicited by yeast from different sources, was readily reversible, and was associated with increased nutrient intake as well as decreased internal ethanol levels. Inhibition of serotonergic neuron function using multiple independent genetic manipulations blocked the effect of yeast supplementation on ethanol sedation, nutrient intake, and internal ethanol levels. Our results demonstrate that yeast is a critical dietary component that influences ethanol sedation in flies and that serotonergic signaling is required for the effect of dietary yeast on nutrient intake, ethanol uptake/elimination, and ethanol sedation. Our studies establish the fly as a model for diet- induced changes in ethanol sedation and raise the possibility that serotonin might mediate the effect of diet on alcohol- related behavior in other species.Flies fed a high yeast diet consume more nutrients, have decreased levels of internal ethanol when exposed to ethanol vapor and require longer exposure to ethanol to become sedated (ie, increased ST50). Our studies implicate serotonergic neurons as key regulators of nutrient consumption and therefore, the effect of dietary yeast on ethanol sedation in flies.
dc.publisherWiley Periodicals, Inc.
dc.publisherAcademic Press
dc.subject.otherdiet
dc.subject.otherbehavior
dc.subject.otherDrosophila
dc.subject.otheralcohol
dc.subject.otherethanol
dc.subject.othersedation
dc.titleDietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurology and Neurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155987/1/adb12779.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/155987/2/adb12779_am.pdf
dc.identifier.doi10.1111/adb.12779
dc.identifier.sourceAddiction Biology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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