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Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling

dc.contributor.authorCampit, Scott E.
dc.contributor.authorMeliki, Alia
dc.contributor.authorYoungson, Neil A.
dc.contributor.authorChandrasekaran, Sriram
dc.date.accessioned2020-09-02T14:58:23Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-09-02T14:58:23Z
dc.date.issued2020-09
dc.identifier.citationCampit, Scott E.; Meliki, Alia; Youngson, Neil A.; Chandrasekaran, Sriram (2020). "Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling." BioEssays 42(9): n/a-n/a.
dc.identifier.issn0265-9247
dc.identifier.issn1521-1878
dc.identifier.urihttps://hdl.handle.net/2027.42/156428
dc.description.abstractSeveral metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the interactions between metabolic pathways and histones. These technologies have shed light on how nutrient availability can have a dramatic effect on various histone modifications. This metabolism–epigenome cross talk plays a fundamental role in development, immune function, and diseases like cancer. Yet, major challenges remain in understanding the interactions between cellular metabolism and the epigenome. How the levels and fluxes of various metabolites impact epigenetic marks is still unclear. Discussed herein are recent applications and the potential of systems biology methods such as flux tracing and metabolic modeling to address these challenges and to uncover new metabolic–epigenetic interactions. These systems approaches can ultimately help elucidate how nutrients shape the epigenome of microbes and mammalian cells.Histone post‐translational modifications (PTMs) sense cellular metabolic state and regulate gene expression, thereby influencing normal physiology and disease progression. While histone PTMs rely on metabolic substrates, how nutrients impact the histone PTM code is unclear. Here, systems biology technologies that can be used to study metabolic–epigenetic interactions are reviewed.
dc.publisherWiley Periodicals, Inc.
dc.publisherHumana
dc.titleNutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelEcology and Evolutionary Biology
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biology
dc.subject.hlbsecondlevelNatural Resources and Environment
dc.subject.hlbtoplevelScience
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/156428/2/bies202000083_am.pdfen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/156428/1/bies202000083.pdfen_US
dc.identifier.doi10.1002/bies.202000083
dc.identifier.sourceBioEssays
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Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

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