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Skeletal muscle ferritin abundance is tightly related to plasma ferritin concentration in adults with obesity
dc.contributor.authorRyan, Benjamin J.
dc.contributor.authorFoug, Katherine L.
dc.contributor.authorGioscia‐ryan, Rachel A.
dc.contributor.authorLudzki, Alison C.
dc.contributor.authorAhn, Cheehoon
dc.contributor.authorSchleh, Michael W.
dc.contributor.authorGillen, Jenna B.
dc.contributor.authorChenevert, Thomas L.
dc.contributor.authorHorowitz, Jeffrey F.
dc.date.accessioned2020-11-04T15:59:12Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2020-11-04T15:59:12Z
dc.date.issued2020-11
dc.identifier.citationRyan, Benjamin J.; Foug, Katherine L.; Gioscia‐ryan, Rachel A. ; Ludzki, Alison C.; Ahn, Cheehoon; Schleh, Michael W.; Gillen, Jenna B.; Chenevert, Thomas L.; Horowitz, Jeffrey F. (2020). "Skeletal muscle ferritin abundance is tightly related to plasma ferritin concentration in adults with obesity." Experimental Physiology 105(11): 1808-1814.
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X
dc.identifier.urihttps://hdl.handle.net/2027.42/163407
dc.description.abstractObesity is associated with complex perturbations to whole- body and tissue iron homeostasis. Recent evidence suggests a potentially important influence of iron storage in skeletal muscle on whole- body iron homeostasis, but this association is not clearly resolved. The primary aim of this study was to assess the relationship between whole- body and skeletal muscle iron stores by measuring the abundance of the key iron storage (ferritin) and import (transferrin receptor) proteins in skeletal muscle, as well as markers of whole- body iron homeostasis in men (n = 19) and women (n = 43) with obesity. Plasma ferritin concentration (a marker of whole- body iron stores) was highly correlated with muscle ferritin abundance (r = 0.77, P = 2 à  10- 13) and negatively associated with muscle transferrin receptor abundance (r = - 0.76, P = 1 à  10- 12). These relationships persisted when accounting for sex, age, BMI and plasma C- reactive protein concentration. In parallel with higher whole- body iron stores in our male versus female participants, men had 2.2- fold higher muscle ferritin abundance (P = 1 à  10- 4) compared with women. In accordance with lower muscle iron storage, women had 2.7- fold higher transferrin receptor abundance (P = 7 à  10- 10) compared with men. We conclude that muscle iron storage and import proteins are tightly and independently related to plasma ferritin concentration in adults with obesity, suggesting that skeletal muscle may be an underappreciated iron store.
dc.publisherWorld Health Organization
dc.publisherWiley Periodicals, Inc.
dc.subject.otherobesity
dc.subject.otherskeletal muscle
dc.subject.otheriron
dc.titleSkeletal muscle ferritin abundance is tightly related to plasma ferritin concentration in adults with obesity
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPhysiology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/163407/2/eph12853_am.pdfen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/163407/1/eph12853.pdfen_US
dc.identifier.doi10.1113/EP089010
dc.identifier.sourceExperimental Physiology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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