U.S. POINTER Imaging: Study design and launch
Lockhart, Samuel N.; Baker, Laura D.; Carrillo, Maria C.; DeCarli, Charles; Espeland, Mark A.; Harvey, Danielle J.; Jack, Clifford R.; Jagust, William J.; Jung, Youngkyoo; Koeppe, Robert A.; Lovato, Laura; Snyder, Heather M.; Toga, Arthur W.; Vemuri, Prashanthi; Woolard, Nancy; Landau, Susan M.
2020-12
Citation
Lockhart, Samuel N.; Baker, Laura D.; Carrillo, Maria C.; DeCarli, Charles; Espeland, Mark A.; Harvey, Danielle J.; Jack, Clifford R.; Jagust, William J.; Jung, Youngkyoo; Koeppe, Robert A.; Lovato, Laura; Snyder, Heather M.; Toga, Arthur W.; Vemuri, Prashanthi; Woolard, Nancy; Landau, Susan M. (2020). "U.S. POINTER Imaging: Study design and launch." Alzheimer’s & Dementia 16: n/a-n/a.
Abstract
BackgroundRecent studies suggest that lifestyle changes (physical exercise, Mediterranean diet adherence, cognitive stimulation, vascular risk management) may protect against cognitive decline and reduce AD pathophysiology. The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a 2‐year randomized controlled trial to evaluate whether lifestyle interventions can protect cognitive function in older adults (60‐79 years) who are at increased risk for cognitive impairment and dementia. The POINTER Imaging ancillary study will assess effects of the POINTER lifestyle interventions on neuroimaging biomarkers of AD and cerebrovascular pathophysiology, and whether baseline neuroimaging measures predict cognitive responses to the interventions.MethodThe POINTER Imaging ancillary study aims to enroll 1250 participants from the five U.S. POINTER sites. Ancillary study participants will undergo PET imaging (Baseline, Month 24) to measure Aβ ([18F]Florbetaben) and tau ([18F]MK‐6240) burden, and MRI (Baseline, Months 12 & 24) to measure brain morphometry, white matter (WM) hyperintensities and microstructure, and cerebral blood flow. U.S. POINTER provides standardized cognitive, clinical, genetic (e.g. APOE), and lifestyle activity assessments, and demographics for integration with neuroimaging data.ResultThe study design and methods for the POINTER Imaging ancillary study will be presented. The study will examine whether: (1) neuroimaging biomarkers at baseline (Aβ, tau, hippocampal volume, WM hyperintensities) predict intervention‐related cognitive changes and (2) biomarker outcomes are differentially modified by participation in lifestyle interventions. It will also examine changes in exploratory biomarkers (tensor‐based morphometry, microstructural integrity, microbleeds, cerebral blood flow).ConclusionThe POINTER Imaging study aims to address gaps in our understanding of how a variety of lifestyle practices (diet, exercise, cognitive stimulation and vascular risk management) influence brain health. In particular, the study will determine whether imaging measurements of AD and cerebrovascular pathophysiology are amenable to improvement with the POINTER lifestyle interventions. It also aims to determine pathological profiles of individuals who benefit most from such interventions.Publisher
Wiley Periodicals, Inc.
ISSN
1552-5260 1552-5279
Other DOIs
Types
Article
Metadata
Show full item recordCollections
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.