View Item 

Show simple item record

Cytomorphology and diagnostic pitfalls of sebaceous and nonsebaceous salivary gland lymphadenoma: A multi‐institutional study
dc.contributor.authorViswanathan, Kartik
dc.contributor.authorMaleki, Zahra
dc.contributor.authorPantanowitz, Liron
dc.contributor.authorCantley, Richard
dc.contributor.authorFaquin, William C.
dc.date.accessioned2021-01-05T18:45:48Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2021-01-05T18:45:48Z
dc.date.issued2021-01
dc.identifier.citationViswanathan, Kartik; Maleki, Zahra; Pantanowitz, Liron; Cantley, Richard; Faquin, William C. (2021). "Cytomorphology and diagnostic pitfalls of sebaceous and nonsebaceous salivary gland lymphadenoma: A multi‐institutional study." Diagnostic Cytopathology 49(1): 83-95.
dc.identifier.issn8755-1039
dc.identifier.issn1097-0339
dc.identifier.urihttps://hdl.handle.net/2027.42/163841
dc.description.abstractBackgroundSalivary gland lymphadenoma (LAD) is a rare benign neoplasm comprising sebaceous (SLAD) and nonsebaceous (NSLAD) types. Despite established histologic criteria, limited data on cytomorphology, tumor heterogeneity, and overlap with other entities make the diagnosis of LAD by fine needle aspiration (FNA) challenging. We describe a multi‐institutional cohort of 14 LADs with cytology, clinical, radiologic, and histopathologic data.MethodsOur cohort included nine SLAD and five NSLAD with corresponding histopathology. Mean patient age and M:F ratio were 60.4 years (range 45‐86 years) and 1:2 for SLADs and 57.4 years (range 42‐80 years) and 1:1.5 for NSLADs, respectively. One NSLAD patient had a germline predisposition for Cowden syndrome. Glass slides and whole slide images of air‐dried Diff‐Quik (DQ), alcohol‐stained Papanicolaou smears (Pap) and cellblocks were reviewed for key cytomorphologic findings.ResultsFNAs from SLAD and NSLADs demonstrated vacuolated and basaloid epithelial clusters within a lymphoid background. Vacuolated cells from SLAD showed sebaceous cells with microvesicular cytoplasm indenting a central nucleus. Vacuolated cells from NSLAD were columnar with eccentric nuclei, corresponding to abluminal glandular cells. SLADs were classified using the Milan System for Reporting Salivary Gland Cytopathology as nondiagnostic (11.1%), nonneoplastic (44.4%), atypia of uncertain significance (AUS) (22.2%), and salivary gland neoplasm of uncertain malignant potential (SUMP) (22.2%). NSLADs were classified as AUS (40%), SUMP (40%) and Benign Neoplasm (20%).ConclusionAlthough rare, knowing the cytologic features of salivary LAD is important to avoid diagnostic pitfalls. Vacuolated cells can be prominent in both SLAD and NSLAD aspirates. Diagnostic issues arise from insufficient sampling of all tumor components leading to marked variation in diagnostic classification of LAD.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.othersalivary
dc.subject.otherfine needle aspiration
dc.subject.otherlymphadenoma
dc.subject.othersebaceous
dc.subject.othernonsebaceous
dc.titleCytomorphology and diagnostic pitfalls of sebaceous and nonsebaceous salivary gland lymphadenoma: A multi‐institutional study
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPathology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/163841/1/dc24602_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/163841/2/dc24602.pdf
dc.identifier.doi10.1002/dc.24602
dc.identifier.sourceDiagnostic Cytopathology
dc.identifier.citedreferenceFirat P, Hosal S, Tutar E, Ruacan S. Sebaceous lymphadenoma of the parotid gland: Journal canadien d’otolaryngologie. J Otolaryngol. 2000; 29 ( 2 ): 114 ‐ 116.
dc.identifier.citedreferenceKara H, Sonmez S, Bagbudar S, Gulluoglu M, Basaran B. Malignant transformation of parotid gland non‐sebaceous Lymphadenoma: case report and review of literature. Head Neck Pathol. 2020. https://doi.org/10.1007/s12105-020-01133-3. Online ahead of print.
dc.identifier.citedreferenceCastelino‐Prabhu S, Li QK, Ali SZ. Nonsebaceous lymphadenoma of the parotid gland: cytopathologic findings and differential diagnosis. Diagn Cytopathol. 2010; 38 ( 2 ): 137 ‐ 140.
dc.identifier.citedreferenceVande Haar MA, DeFrias D, Lin X. Fine‐needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland. Diagn Cytopathol. 2014; 42 ( 11 ): 959 ‐ 963.
dc.identifier.citedreferenceAl‐Essa M. Sebaceous lymphadenoma of parotid gland: a case report of a unique presentation in an immunocompromised patient. J Family Med Prim Care. 2020; 9 ( 2 ): 1202 ‐ 1205.
dc.identifier.citedreferenceBanich J, Reyes CV, Bier‐Laning C. Sebaceous lymphadenoma identified by fine needle aspiration biopsy: a case report. Acta Cytol. 2007; 51 ( 2 ): 211 ‐ 213.
dc.identifier.citedreferenceShekarkhar G, Soleimanpour H, Jafari SH, Zamani F. Sebaceous Lymphadenoma of parotid: imaging, cytological, and histological findings in detail. Case Rep Pathol. 2018; 2018: 1 – 4.
dc.identifier.citedreferenceShukla M, Panicker S. Synchronous sebaceous lymphadenoma with squamous cell carcinoma ‐ case report. World J Surg Oncol. 2003; 1 ( 1 ): 30.
dc.identifier.citedreferenceJo VY, Krane JF. Ancillary testing in salivary gland cytology: a practical guide. Cancer Cytopathol. 2018; 126 ( 8 ): 627 ‐ 642.
dc.identifier.citedreferenceChan JK, Yip TT, Tsang WY, Poon YF, Wong CS, Ma VW. Specific association of Epstein‐Barr virus with lymphoepithelial carcinoma among tumors and tumorlike lesions of the salivary gland. Arch Pathol Lab Med. 1994; 118 ( 10 ): 994 ‐ 997.
dc.identifier.citedreferenceBayer‐Garner IB, Givens V, Smoller B. Immunohistochemical staining for androgen receptors: a sensitive marker of sebaceous differentiation. Am J Dermatopathol. 1999; 21 ( 5 ): 426 ‐ 431.
dc.identifier.citedreferenceAssor D. Sebaceous lymphadenoma of the parotid gland. A case report. Am J Clin Pathol. 1970; 53 ( 1 ): 100 ‐ 103. https://doi.org/10.1093/ajcp/53.1.100
dc.identifier.citedreferenceMayorga M, Fernández N, Val‐Bernal JF. Synchronous ipsilateral sebaceous lymphadenoma and acinic cell adenocarcinoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 88 ( 5 ): 593 ‐ 596.
dc.identifier.citedreferenceBoyle JL, Meschter SC. Fine needle aspiration cytology of a sebaceous lymphadenoma: a case report. Acta Cytol. 2004; 48 ( 4 ): 551 ‐ 554.
dc.identifier.citedreferenceHayashi D, Tysome JR, Boyei E, Gluckman P, Barbaccia C. Sebaceous lymphadenoma of the parotid gland: report of two cases and review of the literature. Acta Otorhinolaryngol Ital. 2007; 27 ( 3 ): 144 ‐ 146.
dc.identifier.citedreferenceChandrasekar T, Ramani P, Anuja N, et al. Unilocular cystic sebaceous lymphadenoma: a rare tumour. Ann R Coll Surg Engl. 2007; 89 ( 4 ): 1 ‐ 3.
dc.identifier.citedreferenceMaffini F, Fasani R, Petrella D, et al. Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature. Acta Otorhinolaryngol Ital. 2007; 27 ( 3 ): 147 ‐ 150.
dc.identifier.citedreferenceMajeed M, Murray B, Hume W, Makura Z. Sebaceous lymphadenoma of the parotid gland. Dentomaxillofac Radiol. 2008; 37 ( 5 ): 300 ‐ 304.
dc.identifier.citedreferenceWhile B, Whiteside OJ, Desai V, Gurr P. Sebaceous lymphadenoma: a case report and review of the literature. Ear Nose Throat J. 2010; 89 ( 8 ): E22 ‐ E23.
dc.identifier.citedreferencePotenziani S, Applebaum D, Krishnan B, Gutiérrez C, Diwan AH. Multiple clear cell acanthomas and a sebaceous lymphadenoma presenting in a patient with Cowden syndrome ‐ a case report. J Cutan Pathol. 2017; 44 ( 1 ): 79 ‐ 82.
dc.identifier.citedreferenceRatsogi N. Sebaceous lymphadenoma of the parotid gland‐a case report of infrequently encountered tumor. Asian Pac. J. Health Sci., 2017; 4 ( 3 ): 6 ‐ 8.
dc.identifier.citedreferenceGallego L, Junquera L, Fresno MF. Non‐sebaceous lymphadenoma of the parotid gland: immunohistochemical study and DNA ploidy analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107 ( 4 ): 555 ‐ 558.
dc.identifier.citedreferenceMabel Cedeño Díaz O, Jesús Fernández Aceñero M, Mullor Nogales R, Pino Jiménez A, Lourdes Maniegas Lozano M, Martínez Pérez D. Non sebaceous lymphadenoma of the parotid gland: Two‐case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2014. 26 ( 2 ): 239 ‐ 243.
dc.identifier.citedreferenceKato T, Nakamizo M, Yokoshima K et al. Non‐sebaceous lymphadenoma of the parotid gland: a report of two cases of superficial parotidectomy. Head and Neck Surgery. 25 ( 3 ): 415 ‐ 420, 2015.
dc.identifier.citedreferenceJazaerly T, Bandyopadhyay S, Almardini N, Husain M. Diagnosis of sebaceous lymphadenoma by fine needle aspiration in a patient with Cowden syndrome: case report and review of the literature. Cytojournal. 2014; 11: 25.
dc.identifier.citedreferenceSeethala RR, LiVolsi VA, Baloch ZW. Relative accuracy of fine‐needle aspiration and frozen section in the diagnosis of lesions of the parotid gland. Head Neck. 2005; 27 ( 3 ): 217 ‐ 223.
dc.identifier.citedreferenceRossi ED, Wong LQ, Bizzarro T, et al. The impact of FNAC in the management of salivary gland lesions: institutional experiences leading to a risk‐based classification scheme. Cancer Cytopathol. 2016; 124 ( 6 ): 388 ‐ 396.
dc.identifier.citedreferenceBarbarite E, Puram SV, Derakhshan A, Rossi ED, Faquin WC, Varvares MA. A call for universal acceptance of the Milan system for reporting salivary gland cytopathology. Laryngoscope. 2020; 130 ( 1 ): 80 ‐ 85.
dc.identifier.citedreferenceJayaram G, Verma AK, Sood N, Khurana N. Fine needle aspiration cytology of salivary gland lesions. J Oral Pathol Med. 1994; 23 ( 6 ): 256 ‐ 261.
dc.identifier.citedreferenceLayfield LJ, Gopez E, Hirschowitz S. Cost efficiency analysis for fine‐needle aspiration in the workup of parotid and submandibular gland nodules. Diagn Cytopathol. 2006; 34 ( 11 ): 734 ‐ 738.
dc.identifier.citedreferenceMairembam P, Jay A, Beale T, et al. Salivary gland FNA cytology: role as a triage tool and an approach to pitfalls in cytomorphology. Cytopathology. 2016; 27 ( 2 ): 91 ‐ 96.
dc.identifier.citedreferenceLayfield LJ, Glasgow BJ. Diagnosis of salivary gland tumors by fine‐needle aspiration cytology: a review of clinical utility and pitfalls. Diagn Cytopathol. 1991; 7 ( 3 ): 267 ‐ 272.
dc.identifier.citedreferenceRossi ED, Faquin WC. The Milan system for reporting salivary gland cytopathology (MSRSGC): an international effort toward improved patient care‐when the roots might be inspired by Leonardo da Vinci. Cancer Cytopathol. 2018; 126 ( 9 ): 756 ‐ 766.
dc.identifier.citedreferenceRawlinson NJ, Almarzooqi S, Nicol K. Sebaceous lymphadenoma of the parotid gland in a 13‐year‐old girl: a case report. Head Neck Pathol. 2010; 4 ( 2 ): 144 ‐ 147.
dc.identifier.citedreferenceSun G, Hu Q, Huang X, Tang E. Sebaceous lymphadenoma of parotid gland in a child. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107 ( 2 ): 253 ‐ 255.
dc.identifier.citedreferenceEl‐Naggar AK, Chan J, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours. 4th ed. Lyon, France: IARC; 2017.
dc.identifier.citedreferencePattnaik N, Parmar D, Rao BR, Rao ES. Sebaceous lymphadenoma of submandibular gland. J Indian Med Assoc. 2013; 111 ( 1 ): 62 ‐ 63.
dc.identifier.citedreferenceSeethala RR, Thompson LD, Gnepp DR, et al. Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol. 2012; 25 ( 1 ): 26 ‐ 35.
dc.identifier.citedreferenceLiu G, He J, Zhang C, Fu S, He Y. Lymphadenoma of the salivary gland: report of 10 cases. Oncol Lett. 2014; 7 ( 4 ): 1097 ‐ 1101.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
dc24602_am.pdf
Size:
7.555MB
Format:
PDF
View/Open
Name:
dc24602.pdf
Size:
2.229MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.