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Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

dc.contributor.authorMirza, Fatima N.
dc.contributor.authorMirza, Humza N.
dc.contributor.authorKhatri, Khalil A.
dc.date.accessioned2021-01-05T18:48:17Z
dc.date.availableWITHHELD_11_MONTHS
dc.date.available2021-01-05T18:48:17Z
dc.date.issued2020-11
dc.identifier.citationMirza, Fatima N.; Mirza, Humza N.; Khatri, Khalil A. (2020). "Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review." Dermatologic Therapy 33(6): n/a-n/a.
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.urihttps://hdl.handle.net/2027.42/163929
dc.description.abstractIt is generally believed that intervention on skin while on isotretinoin or within 6 to 12 months after treatment can lead to prolonged healing and abnormal scarring. The objective of this systematic review is to evaluate the body of evidence on concomitant use of isotretinoin and lasers for adverse events as a consequence of treatment. A PRISMA‐compliant systematic review (Systematic Review Registration Number: CRD42017056492) of 12 electronic databases was conducted for the terms “laser” and “isotretinoin” or associated brand names from inception until June 2020. Subsequent reference search of studies meeting predefined inclusion criteria were conducted, and all articles were evaluated for bias and assigned levels of evidence to facilitate data synthesis. The search strategy produced 29 studies. Of 871 patients included in the studies of interest, 12 experienced transient adverse effects that resolved spontaneously, and only two presented with keloid formation, both from case reports. This systematic review suggests the risk associated with concomitant isotretinoin and laser use is small to absent. Further studies are needed, but these results suggest that current contraindications may be overly cautious.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.othersystematic review
dc.subject.othersafe and effective
dc.subject.otherconcomitant treatment
dc.subject.otherisotretinoin
dc.subject.otherlasers
dc.titleConcomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDermatology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/163929/1/dth14022.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/163929/2/dth14022_am.pdf
dc.identifier.doi10.1111/dth.14022
dc.identifier.sourceDermatologic Therapy
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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