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Chronic inflammatory demyelinating polyradiculoneuropathy—Diagnostic pitfalls and treatment approach

dc.contributor.authorStino, Amro M.
dc.contributor.authorNaddaf, Elie
dc.contributor.authorDyck, Peter J.
dc.contributor.authorDyck, P. James B.
dc.date.accessioned2021-02-04T21:49:03Z
dc.date.available2022-03-04 16:49:00en
dc.date.available2021-02-04T21:49:03Z
dc.date.issued2021-02
dc.identifier.citationStino, Amro M.; Naddaf, Elie; Dyck, Peter J.; Dyck, P. James B. (2021). "Chronic inflammatory demyelinating polyradiculoneuropathy—Diagnostic pitfalls and treatment approach." Muscle & Nerve 63(2): 157-169.
dc.identifier.issn0148-639X
dc.identifier.issn1097-4598
dc.identifier.urihttps://hdl.handle.net/2027.42/166169
dc.description.abstractChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is characterized by progressive weakness and sensory loss, often affecting patientsʼ ability to walk and perform activities of daily living independently. With the lack of a diagnostic biomarker, the diagnosis relies on clinical suspicion, clinical findings, and the demonstration of demyelinating changes on electrodiagnostic (EDx) testing and nerve pathology. As a result, patients can often be misdiagnosed with CIDP and unnecessarily treated with immunotherapy. Interpreting the EDx testing and cerebrospinal fluid findings in light of the clinical phenotype, recognizing atypical forms of CIDP, and screening for CIDP mimickers are the mainstays of the approach to patients suspected of having CIDP, and are detailed in this review. We also review the currently available treatment options, including intravenous immunoglobulin (IVIg), corticosteroids (CCS), and plasma exchange (PE), and discuss how to approach treatment‐refractory cases. Finally, we emphasize the need to adopt objective outcome measures to monitor treatment response.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otherCIDP, diagnosis, IVIg, plasma exchange, steroids, treatment
dc.titleChronic inflammatory demyelinating polyradiculoneuropathy—Diagnostic pitfalls and treatment approach
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/166169/1/mus27046.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/166169/2/mus27046_am.pdf
dc.identifier.doi10.1002/mus.27046
dc.identifier.doihttps://dx.doi.org/10.7302/92
dc.identifier.sourceMuscle & Nerve
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dc.working.doi10.7302/92en
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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