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Microbial and host‐derived biomarker changes during ligature‐induced and spontaneous peri‐implantitis in the Beagle dog
dc.contributor.authorMonje, Alberto
dc.contributor.authorEick, Sigrun
dc.contributor.authorBuser, Daniel
dc.contributor.authorSalvi, Giovanni E.
dc.date.accessioned2021-02-04T21:55:02Z
dc.date.available2022-02-04 16:55:01en
dc.date.available2021-02-04T21:55:02Z
dc.date.issued2021-01
dc.identifier.citationMonje, Alberto; Eick, Sigrun; Buser, Daniel; Salvi, Giovanni E. (2021). "Microbial and host‐derived biomarker changes during ligature‐induced and spontaneous peri‐implantitis in the Beagle dog." Journal of Periodontal Research (1): 93-100.
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.urihttps://hdl.handle.net/2027.42/166284
dc.description.abstractObjectiveTo evaluate microbial and host‐derived biomarker changes during experimental peri‐implantitis in the Beagle dog.BackgroundLimited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri‐implantitis.MethodsIn total, 36 implants (ndogs = 6) were assessed over 3 episodes of ligature‐induced peri‐implantitis followed by a period of spontaneous progression. Implants with hybrid (H) and completely rough (R) surface designs were used. Clinical and radiographic parameters were recorded at 4 timepoints. Peri‐implant sulcus fluid was collected from the buccal and lingual aspects of the implants. The presence of 7 bacterial species and 2 host‐derived biomarkers was assessed during the study period.ResultsTotal bacterial counts were significantly correlated with marginal bone loss (MBL) (r = .21; P = .009). Further, Phorphyromonas gulae (Pg) and Tannerella forsythia (Tf) were commonly correlated with MBL, suppuration (SUP) and the sulcular bleeding index scores (mSBI) (P < .05). Other bacteria were further correlated with SUP, mSBI, and MBL. While the analyzed bacteria dropped, Prevotella intermedia (Pi) further increased during the spontaneous progressive phase (P < .05). Total bacterial load did not differ significantly between H and R implants. Host‐derived IL‐10 was undetected along the study period. IL‐1β positively correlated with probing pocket depth (r = .18; P = .03). During spontaneous progression, H implants displayed statistically significant lower levels of IL‐1β (P = .003).ConclusionExperimental peri‐implantitis is associated with an increase in bacterial counts. While Pg and Tf are associated with ligature‐induced disease progression, Pi augmented its load during the spontaneous progressive phase. IL‐1β is associated with pocket probing depth and influenced by implant surface characteristics during the spontaneous progression phase.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherendosseous implant
dc.subject.otherbiomarker
dc.subject.otherfusobacterium nucleatum
dc.subject.otherperi‐implantitis
dc.subject.otherdental implant
dc.titleMicrobial and host‐derived biomarker changes during ligature‐induced and spontaneous peri‐implantitis in the Beagle dog
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/166284/1/jre12797_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/166284/2/jre12797.pdf
dc.identifier.doi10.1111/jre.12797
dc.identifier.doihttps://dx.doi.org/10.7302/207
dc.identifier.sourceJournal of Periodontal Research
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dc.working.doi10.7302/207en
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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