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Tinnitus and auditory cortex; Using adapted functional near- infrared- spectroscopy to expand brain imaging in humans
dc.contributor.authorZhai, Tianqu
dc.contributor.authorAsh‐rafzadeh, Angela
dc.contributor.authorHu, Xiaosu
dc.contributor.authorKim, Jessica
dc.contributor.authorSan Juan, Juan D.
dc.contributor.authorFilipiak, Charles
dc.contributor.authorGuo, Kaiwen
dc.contributor.authorIslam, Mohammed N.
dc.contributor.authorKovelman, Ioulia
dc.contributor.authorBasura, Gregory J.
dc.date.accessioned2021-03-02T21:45:36Z
dc.date.available2022-03-02 16:45:34en
dc.date.available2021-03-02T21:45:36Z
dc.date.issued2021-02
dc.identifier.citationZhai, Tianqu; Ash‐rafzadeh, Angela ; Hu, Xiaosu; Kim, Jessica; San Juan, Juan D.; Filipiak, Charles; Guo, Kaiwen; Islam, Mohammed N.; Kovelman, Ioulia; Basura, Gregory J. (2021). "Tinnitus and auditory cortex; Using adapted functional near- infrared- spectroscopy to expand brain imaging in humans." Laryngoscope Investigative Otolaryngology 6(1): 137-144.
dc.identifier.issn2378-8038
dc.identifier.issn2378-8038
dc.identifier.urihttps://hdl.handle.net/2027.42/166400
dc.description.abstractObjectivesPhantom sound perception (tinnitus) may arise from altered brain activity within auditory cortex. Auditory cortex neurons in tinnitus animal models show increased spontaneous firing rates. This may be a core characteristic of tinnitus. Functional near- infrared spectroscopy (fNIRS) has shown similar findings in human auditory cortex. Current fNIRS approaches with cap recordings are limited to - ¼3- cm depth of signal penetration due to the skull thickness. To address this limitation, we present an innovative fNIRS approach via probes adapted to the external auditory canal. The adapted probes were placed deeper and closer to temporal lobe of the brain to bypass confining skull bone and improve neural recordings.MethodsTwenty adults with tinnitus and 20 nontinnitus controls listened to periods of silence and broadband noise (BBN) during standard cap and adapted ear canal fNIRS neuroimaging. The evaluators were not blinded, but the protocol and postprocessing for the two groups were identical.ResultsStandard fNIRS measurements in participants with tinnitus revealed increased auditory cortex activity during silence that was suppressed during auditory stimulation with BBN. Conversely, controls displayed increased activation with noise but not during silence. Importantly, adapted ear canal fNIRs probes showed similar hemodynamic responses seen with cap probes in both tinnitus and controls.ConclusionsIn this proof of concept study, we have successfully fabricated, adapted, and utilized a novel fNIRS technology that replicates established findings from traditional cap fNIRS probes. This exciting new innovation, validated by replicating previous and current cap findings in auditory cortex, may have applications to future studies to investigate brain changes not only in tinnitus but in other pathologic states that may involve the temporal lobe and surrounding brain regions.Level of EvidenceNA.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otherauditory cortex
dc.subject.otherfunctional near- infrared spectroscopy
dc.subject.otherhemodynamic responses
dc.subject.othertinnitus
dc.titleTinnitus and auditory cortex; Using adapted functional near- infrared- spectroscopy to expand brain imaging in humans
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/166400/1/lio2510_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/166400/2/lio2510.pdf
dc.identifier.doi10.1002/lio2.510
dc.identifier.sourceLaryngoscope Investigative Otolaryngology
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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