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Investigating host-microbiota interactions in IBD and CDI

dc.contributor.authorGeorge, James
dc.date.accessioned2021-04-29T19:12:19Z
dc.date.available2021-04-29T19:12:19Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/2027.42/167249
dc.identifier.urihttps://youtu.be/jZWQl65q398-Mar
dc.description.abstractClostridioides difficile (C. difficile) has been recognized as a pathogenic bacterium in patients with antibiotic exposure or inflammatory bowel disease (IBD). Similar to antibiotics, IBD has been associated with altered gut microbiotas, which play an important role in colonization resistance to C. difficile. The purpose of this project is to examine the relationship between C. difficile colonization and host-microbiota responses in mouse models of IBD and antibiotic-induced CDI. It was discovered that while both antibiotics and IBD were associated with a decreased gut microbiota diversity, the microbial diversity from the IBD treatment group was more stochastic. Additionally, while the difference between the colonization burden of the antibiotic and IBD treatment group was not significant, the IBD treatment group showed a greater amount of variation. Overall, it was found that IBD has a more stochastic effect on the gut microbiota than antibiotics which suggests that a different mechanism is used to decrease microbial diversity in both situations.
dc.subjectMicrobiome
dc.subjectImmunology
dc.titleInvestigating host-microbiota interactions in IBD and CDI
dc.typeTechnical Report
dc.subject.hlbtoplevelEngineering
dc.contributor.affiliationumDepartment of Microbiology and Immunology
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167249/1/Honors_Capstone_Thesis-James_George.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167249/2/Honors_Capstone_Design_Expo-James_George.pptx
dc.identifier.doihttps://dx.doi.org/10.7302/924
dc.working.doi10.7302/924en
dc.owningcollnameHonors Program, The College of Engineering


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