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Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse
dc.contributor.authorMarkworth, James F.
dc.contributor.authorSugg, Kristoffer B.
dc.contributor.authorSarver, Dylan C.
dc.contributor.authorMaddipati, Krishna Rao
dc.contributor.authorBrooks, Susan V.
dc.date.accessioned2021-06-02T21:05:39Z
dc.date.available2022-07-02 17:05:38en
dc.date.available2021-06-02T21:05:39Z
dc.date.issued2021-06
dc.identifier.citationMarkworth, James F.; Sugg, Kristoffer B.; Sarver, Dylan C.; Maddipati, Krishna Rao; Brooks, Susan V. (2021). "Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse." The FASEB Journal (6): n/a-n/a.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/167767
dc.description.abstractTendon inflammation has been implicated in both adaptive connective tissue remodeling and overuse‐induced tendinopathy. Lipid mediators control both the initiation and resolution of inflammation, but their roles within tendon are largely unknown. Here, we profiled local shifts in intratendinous lipid mediators via liquid chromatography‐tandem mass spectrometry in response to synergist ablation‐induced plantaris tendon overuse. Sixty‐four individual lipid mediators were detected in homogenates of plantaris tendons from ambulatory control rats. This included many bioactive metabolites of the cyclooxygenase (COX), lipoxygenase (LOX), and epoxygenase (CYP) pathways. Synergist ablation induced a robust inflammatory response at day 3 post‐surgery characterized by epitenon infiltration of polymorphonuclear leukocytes and monocytes/macrophages (MΦ), heightened expression of inflammation‐related genes, and increased intratendinous concentrations of the pro‐inflammatory eicosanoids thromboxane B2 and prostaglandin E2. By day 7, MΦ became the predominant myeloid cell type in tendon and there were further delayed increases in other COX metabolites including prostaglandins D2, F2α, and I2. Specialized pro‐resolving mediators including protectin D1, resolvin D2 and D6, as well as related pathway markers of D‐resolvins (17‐hydroxy‐docosahexaenoic acid), E‐resolvins (18‐hydroxy‐eicosapentaenoic acid), and lipoxins (15‐hydroxy‐eicosatetraenoic acid) were also increased locally in response to tendon overuse, as were anti‐inflammatory fatty acid epoxides of the CYP pathway (eg, epoxy‐eicosatrienoic acids). Nevertheless, intratendinous prostaglandins remained markedly increased even following 28 days of tendon overuse together with a lingering MΦ presence. These data reveal a delayed and prolonged local inflammatory response to tendon overuse characterized by an overwhelming predominance of pro‐inflammatory eicosanoids and a relative lack of specialized pro‐resolving lipid mediators.
dc.publisherWiley Periodicals, Inc.
dc.subject.othermass spectrometry
dc.subject.othertendon
dc.subject.otherresolution
dc.subject.othereicosanoid
dc.subject.otherinflammation
dc.subject.otherlipid mediator
dc.titleLocal shifts in inflammatory and resolving lipid mediators in response to tendon overuse
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167767/1/fsb221655.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167767/2/fsb221655_am.pdf
dc.identifier.doi10.1096/fj.202100078R
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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