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Astrocytes in rare neurological conditions: Morphological and functional considerations
dc.contributor.authorRavi, Karthik
dc.contributor.authorPaidas, Michael J.
dc.contributor.authorSaad, Ali
dc.contributor.authorJayakumar, Arumugam R.
dc.date.accessioned2021-06-02T21:07:33Z
dc.date.available2022-08-02 17:07:17en
dc.date.available2021-06-02T21:07:33Z
dc.date.issued2021-07-01
dc.identifier.citationRavi, Karthik; Paidas, Michael J.; Saad, Ali; Jayakumar, Arumugam R. (2021). "Astrocytes in rare neurological conditions: Morphological and functional considerations." Journal of Comparative Neurology 529(10): 2676-2705.
dc.identifier.issn0021-9967
dc.identifier.issn1096-9861
dc.identifier.urihttps://hdl.handle.net/2027.42/167801
dc.description.abstractAstrocytes are a population of central nervous system (CNS) cells with distinctive morphological and functional characteristics that differ within specific areas of the brain and are widely distributed throughout the CNS. There are mainly two types of astrocytes, protoplasmic and fibrous, which differ in morphologic appearance and location. Astrocytes are important cells of the CNS that not only provide structural support, but also modulate synaptic activity, regulate neuroinflammatory responses, maintain the blood–brain barrier, and supply energy to neurons. As a result, astrocytic disruption can lead to widespread detrimental effects and can contribute to the pathophysiology of several neurological conditions. The characteristics of astrocytes in more common neuropathologies such as Alzheimer’s and Parkinson’s disease have significantly been described and continue to be widely studied. However, there still exist numerous rare neurological conditions in which astrocytic involvement is unknown and needs to be explored. Accordingly, this review will summarize functional and morphological changes of astrocytes in various rare neurological conditions based on current knowledge thus far and highlight remaining neuropathologies where astrocytic involvement has yet to be investigated.Astrocytes are essential cells of the CNS with several functions relating to neuronal and overall homeostasis. As a result, astrocytic dysfunction can cause widespread detrimental effects. There still exist numerous rare neurological conditions in which astrocytic involvement is only beginning to be explored. Accordingly, we will detail the role of astrocytes in over 40+ rare neurological conditions through the lens of function and morphology and highlight remaining neuropathologies where astrocytic involvement has yet to be investigated.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.othercentral nervous system
dc.subject.otherfunction
dc.subject.othermorphology
dc.subject.otherneurologic conditions
dc.subject.otherastrocytosis
dc.subject.otherastrocyte
dc.titleAstrocytes in rare neurological conditions: Morphological and functional considerations
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelEcology and Evolutionary Biology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167801/1/cne25118.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167801/2/cne25118_am.pdf
dc.identifier.doi10.1002/cne.25118
dc.identifier.sourceJournal of Comparative Neurology
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