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Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
dc.contributor.authorErdbrügger, Uta
dc.contributor.authorBlijdorp, Charles J.
dc.contributor.authorBijnsdorp, Irene V.
dc.contributor.authorBorràs, Francesc E.
dc.contributor.authorBurger, Dylan
dc.contributor.authorBussolati, Benedetta
dc.contributor.authorByrd, James Brian
dc.contributor.authorClayton, Aled
dc.contributor.authorDear, James W.
dc.contributor.authorFalcón‐pérez, Juan M.
dc.contributor.authorGrange, Cristina
dc.contributor.authorHill, Andrew F.
dc.contributor.authorHolthöfer, Harry
dc.contributor.authorHoorn, Ewout J.
dc.contributor.authorJenster, Guido
dc.contributor.authorJimenez, Connie R.
dc.contributor.authorJunker, Kerstin
dc.contributor.authorKlein, John
dc.contributor.authorKnepper, Mark A.
dc.contributor.authorKoritzinsky, Erik H.
dc.contributor.authorLuther, James M.
dc.contributor.authorLenassi, Metka
dc.contributor.authorLeivo, Janne
dc.contributor.authorMertens, Inge
dc.contributor.authorMusante, Luca
dc.contributor.authorOeyen, Eline
dc.contributor.authorPuhka, Maija
dc.contributor.authorRoyen, Martin E.
dc.contributor.authorSánchez, Catherine
dc.contributor.authorSoekmadji, Carolina
dc.contributor.authorThongboonkerd, Visith
dc.contributor.authorSteijn, Volkert
dc.contributor.authorVerhaegh, Gerald
dc.contributor.authorWebber, Jason P.
dc.contributor.authorWitwer, Kenneth
dc.contributor.authorYuen, Peter S.T.
dc.contributor.authorZheng, Lei
dc.contributor.authorLlorente, Alicia
dc.contributor.authorMartens‐uzunova, Elena S.
dc.date.accessioned2021-06-02T21:08:47Z
dc.date.available2022-06-02 17:08:45en
dc.date.available2021-06-02T21:08:47Z
dc.date.issued2021-05
dc.identifier.citationErdbrügger, Uta ; Blijdorp, Charles J.; Bijnsdorp, Irene V.; Borràs, Francesc E. ; Burger, Dylan; Bussolati, Benedetta; Byrd, James Brian; Clayton, Aled; Dear, James W.; Falcón‐pérez, Juan M. ; Grange, Cristina; Hill, Andrew F.; Holthöfer, Harry ; Hoorn, Ewout J.; Jenster, Guido; Jimenez, Connie R.; Junker, Kerstin; Klein, John; Knepper, Mark A.; Koritzinsky, Erik H.; Luther, James M.; Lenassi, Metka; Leivo, Janne; Mertens, Inge; Musante, Luca; Oeyen, Eline; Puhka, Maija; Royen, Martin E.; Sánchez, Catherine ; Soekmadji, Carolina; Thongboonkerd, Visith; Steijn, Volkert; Verhaegh, Gerald; Webber, Jason P.; Witwer, Kenneth; Yuen, Peter S.T.; Zheng, Lei; Llorente, Alicia; Martens‐uzunova, Elena S. (2021). "Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles." Journal of Extracellular Vesicles 10(7): n/a-n/a.
dc.identifier.issn2001-3078
dc.identifier.issn2001-3078
dc.identifier.urihttps://hdl.handle.net/2027.42/167823
dc.description.abstractUrine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast- growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV- based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field.
dc.publisherRegulatory Affairs Professionals Society
dc.publisherWiley Periodicals, Inc.
dc.subject.otherbiobank
dc.subject.otherbladder
dc.subject.otherextracellular vesicles
dc.subject.otherkidney
dc.subject.otherliquid biopsy
dc.subject.otherprostate
dc.subject.otherrigor and standardization
dc.subject.otherurine
dc.subject.otherbiomarkers
dc.titleUrinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167823/1/jev212093_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/167823/2/jev212093.pdf
dc.identifier.doi10.1002/jev2.12093
dc.identifier.sourceJournal of Extracellular Vesicles
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