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Lysyl oxidase interactions with transforming growth factor- β during angiogenesis are mediated by endothelin 1
dc.contributor.authorGrunwald, Hagar
dc.contributor.authorHunker, Kristina L.
dc.contributor.authorBirt, Isabelle
dc.contributor.authorAviram, Rohtem
dc.contributor.authorZaffryar‐eilot, Shelly
dc.contributor.authorGanesh, Santhi K.
dc.contributor.authorHasson, Peleg
dc.date.accessioned2021-09-08T14:35:09Z
dc.date.available2022-10-08 10:35:06en
dc.date.available2021-09-08T14:35:09Z
dc.date.issued2021-09
dc.identifier.citationGrunwald, Hagar; Hunker, Kristina L.; Birt, Isabelle; Aviram, Rohtem; Zaffryar‐eilot, Shelly ; Ganesh, Santhi K.; Hasson, Peleg (2021). "Lysyl oxidase interactions with transforming growth factor- β during angiogenesis are mediated by endothelin 1." The FASEB Journal (9): n/a-n/a.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/169278
dc.description.abstractCrosstalk between multiple components underlies the formation of mature vessels. Although the players involved in angiogenesis have been identified, mechanisms underlying the crosstalk between them are still unclear. Using the ex vivo aortic ring assay, we set out to dissect the interactions between two key angiogenic signaling pathways, vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ), with members of the lysyl oxidase (LOX) family of matrix modifying enzymes. We find an interplay between VEGF, TGFβ, and the LOXs is essential for the formation of mature vascular smooth muscle cells (vSMC)- coated vessels. RNA sequencing analysis further identified an interaction with the endothelin- 1 pathway. Our work implicates endothelin- 1 downstream of TGFβ in vascular maturation and demonstrate the complexity of processes involved in generating vSMC- coated vessels.
dc.publisherWiley Periodicals, Inc.
dc.subject.othervascular maturation
dc.subject.otherTGF- beta
dc.subject.otherangiogenesis
dc.subject.otherendothelin
dc.subject.otherlysyl oxidase
dc.titleLysyl oxidase interactions with transforming growth factor- β during angiogenesis are mediated by endothelin 1
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/169278/1/fsb221824.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/169278/2/fsb221824-sup-0006-TableS1.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/169278/3/fsb221824-sup-0007-TableS2.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/169278/4/fsb221824_am.pdf
dc.identifier.doi10.1096/fj.202001860RR
dc.identifier.sourceThe FASEB Journal
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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