Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
dc.contributor.author | Bozadjieva-Kramer, Nadejda | |
dc.contributor.author | Shin, Jae Hoon | |
dc.contributor.author | Shao, Yikai | |
dc.contributor.author | Gutierrez-Aguilar, Ruth | |
dc.contributor.author | Li, Ziru | |
dc.contributor.author | Heppner, Kristy M | |
dc.contributor.author | Chiang, Samuel | |
dc.contributor.author | Vargo, Sara G | |
dc.contributor.author | Granger, Katrina | |
dc.contributor.author | Sandoval, Darleen A | |
dc.contributor.author | MacDougald, Ormond A | |
dc.contributor.author | Seeley, Randy J | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2021-09-21T20:54:29Z | |
dc.date.available | 2021-09-21T20:54:29Z | |
dc.date.issued | 2021-08-06 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/34362888 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/169579 | en |
dc.description.abstract | Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide the most effective improvements in obesity and Type 2 diabetes. We hypothesized a potential role for the gut hormone Fibroblast-Growth Factor 15/19 which is increased after VSG and pharmacologically can improve energy homeostasis and glucose handling. We generated intestinal-specific FGF15 knockout (FGF15INT-KO) mice which were maintained on high-fat diet. FGF15INT-KO mice lost more weight after VSG as a result of increased lean tissue loss. FGF15INT-KO mice also lost more bone density and bone marrow adipose tissue after VSG. The effect of VSG to improve glucose tolerance was also absent in FGF15INT-KO. VSG resulted in increased plasma bile acid levels but were considerably higher in VSG-FGF15INT-KO mice. These data point to an important role after VSG for intestinal FGF15 to protect the organism from deleterious effects of VSG potentially by limiting the increase in circulating bile acids. | |
dc.format.medium | Electronic | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.haspart | ARTN 4768 | |
dc.rights | Licence for published version: Creative Commons Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adipose Tissue | |
dc.subject | Animals | |
dc.subject | Bariatric Surgery | |
dc.subject | Bile Acids and Salts | |
dc.subject | Blood Glucose | |
dc.subject | Bone Density | |
dc.subject | Bone Marrow | |
dc.subject | Diabetes Mellitus, Type 2 | |
dc.subject | Diet, High-Fat | |
dc.subject | Disease Models, Animal | |
dc.subject | Fibroblast Growth Factors | |
dc.subject | Gastrectomy | |
dc.subject | Glucose Tolerance Test | |
dc.subject | Homeostasis | |
dc.subject | Male | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Knockout | |
dc.subject | Obesity | |
dc.subject | Weight Loss | |
dc.title | Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice | |
dc.type | Article | |
dc.identifier.pmid | 34362888 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/169579/2/s41467-021-24914-y.pdf | en |
dc.identifier.doi | 10.1038/s41467-021-24914-y | |
dc.identifier.doi | https://dx.doi.org/10.7302/2624 | |
dc.identifier.source | Nature Communications | |
dc.description.version | Accepted version | |
dc.date.updated | 2021-09-21T20:54:23Z | |
dc.identifier.orcid | 0000-0001-6907-7960 | |
dc.identifier.orcid | 0000-0002-3721-5625 | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 4768 | |
dc.identifier.name-orcid | Bozadjieva-Kramer, Nadejda | |
dc.identifier.name-orcid | Shin, Jae Hoon | |
dc.identifier.name-orcid | Shao, Yikai | |
dc.identifier.name-orcid | Gutierrez-Aguilar, Ruth | |
dc.identifier.name-orcid | Li, Ziru | |
dc.identifier.name-orcid | Heppner, Kristy M | |
dc.identifier.name-orcid | Chiang, Samuel | |
dc.identifier.name-orcid | Vargo, Sara G | |
dc.identifier.name-orcid | Granger, Katrina | |
dc.identifier.name-orcid | Sandoval, Darleen A | |
dc.identifier.name-orcid | MacDougald, Ormond A; 0000-0001-6907-7960 | |
dc.identifier.name-orcid | Seeley, Randy J; 0000-0002-3721-5625 | |
dc.working.doi | 10.7302/2624 | en |
dc.owningcollname | Surgery, Department of |
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