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Assessing early erythrolysis and the relationship to perihematomal iron overload and white matter survival in human intracerebral hemorrhage
dc.contributor.authorNovakovic, Nemanja
dc.contributor.authorWilseck, Zachary M.
dc.contributor.authorChenevert, Thomas L.
dc.contributor.authorXi, Guohua
dc.contributor.authorKeep, Richard F.
dc.contributor.authorPandey, Aditya S.
dc.contributor.authorChaudhary, Neeraj
dc.date.accessioned2021-10-05T15:06:32Z
dc.date.available2022-11-05 11:06:31en
dc.date.available2021-10-05T15:06:32Z
dc.date.issued2021-10
dc.identifier.citationNovakovic, Nemanja; Wilseck, Zachary M.; Chenevert, Thomas L.; Xi, Guohua; Keep, Richard F.; Pandey, Aditya S.; Chaudhary, Neeraj (2021). "Assessing early erythrolysis and the relationship to perihematomal iron overload and white matter survival in human intracerebral hemorrhage." CNS Neuroscience & Therapeutics (10): 1118-1126.
dc.identifier.issn1755-5930
dc.identifier.issn1755-5949
dc.identifier.urihttps://hdl.handle.net/2027.42/170232
dc.description.abstractAimsIron released from lysed red blood cells within the hematoma plays a role in intracerebral hemorrhage (ICH)‐related neurotoxicity. This study utilizes magnetic resonance imaging (MRI) to examine the time course, extent of erythrolysis, and its correlation with perihematomal iron accumulation and white matter loss.MethodsThe feasibility of assessing proportional erythrolysis using T2* MRI was examined using pig blood phantoms with specified degrees of erythrolysis. Fifteen prospectively enrolled ICH patients had MRIs (3‐Tesla) at days 1–3, 14, and 30 (termed early, subacute, and late periods, respectively). Measurement was performed on T2*, 1/T2*, and fractional anisotropy (FA) maps.ResultsPig blood phantoms showed a linear relationship between 1/T2* signal and percent erythrolysis. MRI on patients showed an increase in erythrolysis within the hematoma between the early and subacute phases after ICH, almost completing by day 14. Although perihematomal iron overload (IO) correlated with the erythrolysis extent and hematoma volume at days 14 and 30, perihematomal white matter (WM) loss significantly correlated with both, only at day 14.ConclusionMRI may reliably assess the portion of the hematoma that lyses over time after ICH. Perihematomal IO and WM loss correlate with both the erythrolysis extent and hematoma volume in the early and subacute periods following ICH.First study to quantify erythrolysis within hematoma in human intracerebral and correlate with perihematomal iron overload and white matter injury.
dc.publisherWiley Periodicals, Inc.
dc.subject.othermagnetic resonance imaging
dc.subject.othererythrolysis
dc.subject.otherhematoma
dc.subject.otherintracerebral hemorrhage
dc.subject.otheriron overload
dc.subject.otherwhite matter loss
dc.titleAssessing early erythrolysis and the relationship to perihematomal iron overload and white matter survival in human intracerebral hemorrhage
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurology and Neurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/170232/1/cns13693.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/170232/2/cns13693_am.pdf
dc.identifier.doi10.1111/cns.13693
dc.identifier.sourceCNS Neuroscience & Therapeutics
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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