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Allo‐anti‐M: Detection peaks around 2 years of age, but may be attenuated by red blood cell transfusion

dc.contributor.authorTamai, Yoshiko
dc.contributor.authorOhto, Hitoshi
dc.contributor.authorYasuda, Hiroyasu
dc.contributor.authorTakeshita, Akihiro
dc.contributor.authorFujii, Nobuharu
dc.contributor.authorOgo, Hiroaki
dc.contributor.authorYazawa, Yurika
dc.contributor.authorHato, Takaaki
dc.contributor.authorMitani, Kinuko
dc.contributor.authorSuzuki, Keijiro
dc.contributor.authorYokohama, Akihiko
dc.contributor.authorKato, Yoko
dc.contributor.authorAbe, Misao
dc.contributor.authorKumagawa, Midori
dc.contributor.authorUeda, Yasunori
dc.contributor.authorNollet, Kenneth E.
dc.contributor.authorCooling, Laura
dc.contributor.authorKitazawa, Junichi
dc.date.accessioned2021-10-05T15:06:46Z
dc.date.available2022-10-05 11:06:44en
dc.date.available2021-10-05T15:06:46Z
dc.date.issued2021-09
dc.identifier.citationTamai, Yoshiko; Ohto, Hitoshi; Yasuda, Hiroyasu; Takeshita, Akihiro; Fujii, Nobuharu; Ogo, Hiroaki; Yazawa, Yurika; Hato, Takaaki; Mitani, Kinuko; Suzuki, Keijiro; Yokohama, Akihiko; Kato, Yoko; Abe, Misao; Kumagawa, Midori; Ueda, Yasunori; Nollet, Kenneth E.; Cooling, Laura; Kitazawa, Junichi (2021). "Allo‐anti‐M: Detection peaks around 2 years of age, but may be attenuated by red blood cell transfusion." Transfusion 61(9): 2718-2726.
dc.identifier.issn0041-1132
dc.identifier.issn1537-2995
dc.identifier.urihttps://hdl.handle.net/2027.42/170235
dc.description.abstractBackgroundAnti‐M is frequently observed as a naturally occurring antibody of little clinical significance. Naturally occurring anti‐M is often found in children although the specific triggers of production, persistence, and evanescence of anti‐M have yet to be elucidated.MethodsIn a retrospective, multicenter, nationwide cohort survey conducted from 2001 to 2015, alloantibody screening was performed before and after transfusion in 18,944 recipients younger than 20 years. Recipients were categorized into six cohorts based on their age at transfusion; within and among these cohorts, allo‐anti‐M was analyzed in regard to its production, persistence, and evanescence.ResultsIn 44 patients, anti‐M detected before and/or after transfusion was an age‐related phenomenon, with a median age of 2 years and an interquartile range of 1–3 years; anti‐M was most frequently detected in a cohort of children 1 to <5 years (0.77%, 31 of 4035). At least five patients were presumed to have concurrent infections. Among 1575 adolescents/young adults (15 to <20 years), no anti‐M was detected. Of 29 patients with anti‐M prior to transfusion, the antibody fell to undetectable levels in 17 recipients (89.5%, of whom at least 13 received only M‐negative red cells) after anywhere from 5 days to 5.8 years; anti‐M persisted in 2, and was not tested in 10. Only 15 recipients (0.08%) produced new anti‐M after transfusion.ConclusionNaturally occurring anti‐M is a phenomenon of younger ages, predominantly between 1 and 3 years. After transfusion, it often falls to undetectable levels.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otheranti‐M
dc.subject.otherchild
dc.subject.otherinfection
dc.subject.othernaturally occurring antibody
dc.titleAllo‐anti‐M: Detection peaks around 2 years of age, but may be attenuated by red blood cell transfusion
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOncology and Hematology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/170235/1/trf16594.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/170235/2/trf16594_am.pdf
dc.identifier.doi10.1111/trf.16594
dc.identifier.sourceTransfusion
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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