View Item 

Show simple item record

Cognitive impairment burden in older and younger adults across the kidney transplant care continuum
dc.contributor.authorChu, Nadia M.
dc.contributor.authorChen, Xiaomeng
dc.contributor.authorGross, Alden L.
dc.contributor.authorCarlson, Michelle C.
dc.contributor.authorGaronzik‐Wang, Jacqueline M.
dc.contributor.authorNorman, Silas P.
dc.contributor.authorMathur, Aarti
dc.contributor.authorAbidi, Maheen Z.
dc.contributor.authorBrennan, Daniel C.
dc.contributor.authorSegev, Dorry L.
dc.contributor.authorMcadams‐Demarco, Mara A.
dc.date.accessioned2021-12-02T02:31:41Z
dc.date.available2022-11-01 21:31:40en
dc.date.available2021-12-02T02:31:41Z
dc.date.issued2021-10
dc.identifier.citationChu, Nadia M.; Chen, Xiaomeng; Gross, Alden L.; Carlson, Michelle C.; Garonzik‐Wang, Jacqueline M. ; Norman, Silas P.; Mathur, Aarti; Abidi, Maheen Z.; Brennan, Daniel C.; Segev, Dorry L.; Mcadams‐Demarco, Mara A. (2021). "Cognitive impairment burden in older and younger adults across the kidney transplant care continuum." Clinical Transplantation 35(10): n/a-n/a.
dc.identifier.issn0902-0063
dc.identifier.issn1399-0012
dc.identifier.urihttps://hdl.handle.net/2027.42/171037
dc.description.abstractBackgroundYounger kidney transplant (KT) candidates and recipients may have cognitive impairment due to chronic diseases and reliance on dialysis.MethodsTo quantify cognitive impairment burden by age across the KT care continuum, we leveraged a two- center cohort study of 3854 KT candidates at evaluation, 1114 recipients at admission, and 405 recipients at 1- year post- KT with measured global cognitive performance (3MS) or executive function (Trail Making Test). We also estimated burden of severe cognitive impairment that affects functional dependence (activities of daily living [ADL] < 6 or instrumental activities of daily living [IADL] < 8).ResultsAmong KT candidates, global cognitive impairment (18- 34 years: 11.1%; 35- 49 years: 14.0%; 50- 64 years: 19.5%; - ¥65 years: 22.0%) and severe cognitive impairment burden (18- 34 years: 1.1%; 35- 49 years: 3.0%; 50- 64 years: 6.2%; - ¥65 years: 7.7%) increased linearly with age. Among KT recipients at admission, global cognitive impairment (18- 34 years: 9.1%; 35- 49 years: 6.1%; 50- 64 years: 9.3%; - ¥65 years: 15.7%) and severe cognitive impairment burden (18- 34 years: 1.4%; 35- 49 years: 1.4%; 50- 64 years: 2.2%; - ¥65 years: 4.6%) was lower. Despite lowest burden of cognitive impairment among KT recipients at 1- year post- KT across all ages (18- 34 years: 1.7%; 35- 49 years: 3.4%; 50- 64 years: 4.3%; - ¥65 years: 6.5%), many still exhibited severe cognitive impairment (18- 34 years: .0%; 35- 49 years: 1.9%; 50- 64 years: 2.4%; - ¥65 years: 3.5%).ConclusionFindings were consistent for executive function impairment. While cognitive impairment increases with age, younger KT candidates have a high burden comparable to community- dwelling older adults, with some potentially suffering from severe forms. Transplant centers should consider routinely screening patients during clinical care encounters regardless of age.
dc.publisherAmerican Chemical Society
dc.publisherWiley Periodicals, Inc.
dc.subject.otherage
dc.subject.othercognition
dc.subject.otherepidemiology
dc.subject.otherkidney disease
dc.subject.othertransplantation
dc.titleCognitive impairment burden in older and younger adults across the kidney transplant care continuum
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171037/1/ctr14425.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171037/2/ctr14425_am.pdf
dc.identifier.doi10.1111/ctr.14425
dc.identifier.sourceClinical Transplantation
dc.identifier.citedreferenceLevine B, Stuss DT, Winocur G, et al. Cognitive rehabilitation in the elderly: effects on strategic behavior in relation to goal management. J. Int. Neuropsychol. Soc. 2007; 13 ( 1 ): 143 - 152.
dc.identifier.citedreferencePetersen RC. Mild cognitive impairment. Continuum (Minneap Minn). 2016; 22: 404 - 418. 2. Dementia.
dc.identifier.citedreferenceSánchez- Fernández MDM, Reyes Del Paso GA, Gil- Cunquero JM, Fernández- Serrano MJ. Executive function in end- stage renal disease: acute effects of hemodialysis and associations with clinical factors. PloS One. 2018; 13 ( 9 ). e0203424- e0203424.
dc.identifier.citedreferencePereira AA, Weiner DE, Scott T, Sarnak MJ. Cognitive function in dialysis patients. Am J Kidney Dis. 2005; 45 ( 3 ): 448 - 462.
dc.identifier.citedreferenceSarnak MJ, Tighiouart H, Scott TM, et al. Frequency of and risk factors for poor cognitive performance in hemodialysis patients. Neurology. 2013; 80 ( 5 ): 471 - 480.
dc.identifier.citedreferenceKim ED, Meoni LA, Jaar BG, et al. Association of arterial stiffness and central pressure with cognitive function in incident hemodialysis patients: the PACE study. Kidney Int Rep. 2017; 2 ( 6 ): 1149 - 1159.
dc.identifier.citedreferenceChu NM, Segev D, Mcadams- Demarco MA. Interventions to preserve cognitive functioning among older kidney transplant recipients. Curr. Transplant. Rep. 2020; 7 ( 4 ): 346 - 354.
dc.identifier.citedreferenceLanga KM, Levine DA. The diagnosis and management of mild cognitive impairment: a clinical review. JAMA. 2014; 312 ( 23 ): 2551 - 2561.
dc.identifier.citedreferenceMahncke HW, Connor BB, Appelman J, et al. Memory enhancement in healthy older adults using a brain plasticity- based training program: a randomized, controlled study. PNAS. 2006; 103 ( 33 ): 12523 - 12528.
dc.identifier.citedreferenceCepeda NJ, Kramer AF, Gonzalez De Sather JCM. Changes in executive control across the life span: examination of task- switching performance. Dev Psychol. 2001; 37 ( 5 ): 715 - 730.
dc.identifier.citedreferenceGriva K, Stygall J, Hankins M, et al. Cognitive impairment and 7- year mortality in dialysis patients. Am. J. Kidney Dis. 2010; 56 ( 4 ): 693 - 703.
dc.identifier.citedreferenceMcadams- Demarco MA, Konel J, Warsame F, et al. Intradialytic cognitive and exercise training may preserve cognitive function. Kidney Int Rep. 2018; 3 ( 1 ): 81 - 88.
dc.identifier.citedreferenceAlley D, Suthers K, Crimmins E. Education and cognitive decline in Older Americans: results from the AHEAD Sample. Res. Aging. 2007; 29 ( 1 ): 73 - 94.
dc.identifier.citedreferenceWilson RS, Hebert LE, Scherr PA, et al. Educational attainment and cognitive decline in old age. Neurology. 2009; 72 ( 5 ): 460 - 465.
dc.identifier.citedreferenceLee HB, Richardson AK, Black BS, et al. Race and cognitive decline among community- dwelling elders with mild cognitive impairment: findings from the Memory and Medical Care Study. Aging Mental Health. 2012; 16 ( 3 ): 372 - 377.
dc.identifier.citedreferenceZhang Z, Hayward MD, Yu Y- L. Life course pathways to racial disparities in cognitive impairment among older Americans. J. Health Soc. Behav. 2016; 57 ( 2 ): 184 - 199.
dc.identifier.citedreferenceNeumann D, Mau W, Wienke A, et al. Peritoneal dialysis is associated with better cognitive function than hemodialysis over a one- year course. Kidney Int. 2018; 93 ( 2 ): 430 - 438.
dc.identifier.citedreferenceHarhay MN, Xie D, Zhang X, Hsu C- Y, et al. Cognitive impairment in non- dialysis- dependent CKD and the transition to dialysis: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Am. J. Kidney Dis. 2018; 72 ( 4 ): 499 - 508.
dc.identifier.citedreferenceMacknight C, Rockwood K, Awalt E, et al. Diabetes mellitus and the risk of dementia, Alzheimer’s disease and vascular cognitive impairment in the Canadian Study of Health and Aging. Dement. Geriatr. Cogn. Disord. 2002; 14 ( 2 ): 77 - 83.
dc.identifier.citedreferenceYaffe K, Peltz CB, Ewing SK, et al. Long- term cognitive trajectories and mortality in older women. J. Gerontol. A Biol. Sci. Med. Sci. 2016; 71 ( 8 ): 1074 - 1080.
dc.identifier.citedreferenceNguyen HaT, Grzywacz JG, Arcury TA, et al. Linking glycemic control and executive function in rural older adults with diabetes mellitus. J. Am. Geriatr. Soc. 2010; 58 ( 6 ): 1123 - 1127.
dc.identifier.citedreferenceVincent C, Hall PA. Executive function in adults with type 2 diabetes: a meta- analytic review. Psychosom. Med. 2015; 77 ( 6 ): 631 - 642.
dc.identifier.citedreferenceChu NM, Bandeen- Roche K, Xue Q- L, et al. Physical frailty phenotype criteria and their synergistic association on cognitive functioning. J. Gerontol. Series A. 2020.
dc.identifier.citedreferenceGross AL, Xue Q- Li, Bandeen- Roche K, et al. Declines and impairment in executive function predict onset of physical frailty. J. Gerontol. A Biol. Sci. Med. Sci. 2016; 71 ( 12 ): 1624 - 1630.
dc.identifier.citedreferenceChu NM, Xue Q- Li, Mcadams- Demarco MA, et al. Frailty- A risk factor of global and domain- specific cognitive decline among a nationally representative sample of community- dwelling older adult US Medicare Beneficiaries. Age Ageing. 2021. press.
dc.identifier.citedreferenceRuss TC, Batty GD, Hearnshaw GF, et al. Geographical variation in dementia: systematic review with meta- analysis. Int. J. Epidemiol. 2012; 41 ( 4 ): 1012 - 1032.
dc.identifier.citedreferenceMcdowell I, Kristjansson B, Hill GB, Hébert R. Community screening for dementia: the Mini Mental State Exam (MMSE) and Modified Mini- Mental State Exam (3MS) compared. J. Clin. Epidemiol. 1997; 50 ( 4 ): 377 - 383.
dc.identifier.citedreferenceTeng E, Chui H, Gong A. Comparisons between the Mini- Mental State Exam (MMSE) and its modified version: the 3MS test. Psychogeriatrics. 1990; 59: 189 - 192.
dc.identifier.citedreferenceTombaugh T. Test- retest reliable coefficients and 5- year change scores for the MMSE and 3MS. Arch. Clin. Neuropsychol. 2005; 20 ( 4 ): 485 - 503.
dc.identifier.citedreferenceJones TG, Schinka JA, Vanderploeg RD, et al. 3MS normative data for the elderly. Arch. Clin. Neuropsychol. 2002; 17 ( 2 ): 171 - 177.
dc.identifier.citedreferenceTombaugh T. Trail Making Test A and B: normative data stratified by age and education. Arch. Clin. Neuropsychol. 2004; 19 ( 2 ): 203 - 214.
dc.identifier.citedreferenceAnthony JC, Leresche L, Niaz U, et al. Limits of the - Mini- Mental State- as a screening test for dementia and delirium among hospital patients. Psychol. Med. 1982; 12 ( 2 ): 397 - 408.
dc.identifier.citedreferenceMcadams- Demarco MA, Konel J, Warsame F, et al. Intradialytic cognitive and exercise training may preserve cognitive function. Kid. Int. Rep. 2018; 3 ( 1 ): 81 - 88.
dc.identifier.citedreferenceHarrell FE Jr. Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis. New York: Springer; 2001.
dc.identifier.citedreferenceTamura MK, Larive B, Unruh ML, et al. Prevalence and correlates of cognitive impairment in hemodialysis patients: the Frequent Hemodialysis Network trials. CJASN. 2010; 5 ( 8 ): 1429 - 1438.
dc.identifier.citedreferenceChu NM, Mcadams- Demarco MA. Exercise and cognitive function in patients with end- stage kidney disease. Seminars in dialysis. 2019.
dc.identifier.citedreferenceMcadams- Demarco MA, Tan J, Salter ML, et al. Frailty and Cognitive Function in Incident Hemodialysis Patients. Clin. J. Am. Soc. Nephrol. 2015; 10 ( 12 ): 2181 - 2189.
dc.identifier.citedreferenceKurella Tamura M, Vittinghoff E, Hsu C- Y, et al. Loss of executive function after dialysis initiation in adults with chronic kidney disease. Kidney Int. 2017; 91 ( 4 ): 948 - 953.
dc.identifier.citedreferenceIyasere O, Brown EA. Cognitive function before and after dialysis initiation in adults with chronic kidney disease- a new perspective on an old problem?. Kidney Int. 2017; 91 ( 4 ): 784 - 786.
dc.identifier.citedreferenceKurella Tamura M, Yaffe K. Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies. Kidney Int. 2011; 79 ( 1 ): 14 - 22.
dc.identifier.citedreferenceDrew DA, Weiner DE, Tighiouart H, et al. Cognitive function and all- cause mortality in maintenance hemodialysis patients. Am. J. Kidney Dis. 2015; 65 ( 2 ): 303 - 311.
dc.identifier.citedreferenceChu NM, Shi Z, Haugen CE, et al. Cognitive function, access to kidney transplantation, and waitlist mortality among kidney transplant candidates with or without diabetes. Am. J. Kidney Dis. 2020.
dc.identifier.citedreferenceChu NM, Gross AL, Shaffer AA, et al. Frailty and changes in cognitive function after kidney transplantation. J. Am. Soc. Nephrol. 2019.
dc.identifier.citedreferenceMurray AM, Tupper DE, Knopman DS, et al. Cognitive impairment in hemodialysis patients is common. Neurology. 2006; 67 ( 2 ): 216 - 223.
dc.identifier.citedreferenceKalirao P, Pederson S, Foley RN, et al. Cognitive impairment in peritoneal dialysis patients. Am. J. Kidney Dis. 2011; 57 ( 4 ): 612 - 620.
dc.identifier.citedreferenceSehgal AR, Grey SF, Deoreo PB, Whitehouse PJ. Prevalence, recognition, and implications of mental impairment among hemodialysis patients. Am. J. Kidney Dis. 1997; 30 ( 1 ): 41 - 49.
dc.identifier.citedreferenceGupta A, Montgomery RN, Bedros V, et al. Subclinical cognitive impairment and listing for kidney transplantation. Clin. J. Am. Soc. Nephrol. 2019. CJN.11010918.
dc.identifier.citedreferenceThomas A, Ruck J, Shaffer A, et al. Kidney transplant outcomes in recipients with cognitive impairment: a National Registry and Prospective Cohort study. Transplantation. 2018.
dc.identifier.citedreferenceChu NM, Sison S, Muzaale AD, et al. Functional independence, access to kidney transplantation and waitlist mortality. Nephrol. Dial. Transplant. 2019.
dc.identifier.citedreferencePereira AA, Weiner DE, Scott T, et al. Subcortical cognitive impairment in dialysis patients. Hemodial Int. 2007; 11 ( 3 ): 309 - 314.
dc.identifier.citedreferenceMcAdams- DeMarco MA, Van Pilsum Rasmussen SE, Chu NM, et al. Perceptions and practices regarding frailty in kidney transplantation: results of A National Survey. 2019. in press.
dc.identifier.citedreferenceHarada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin. Geriatr. Med. 2013; 29 ( 4 ): 737 - 752.
dc.identifier.citedreferenceSalthouse TA. Selective review of cognitive aging. JINS. 2010; 16 ( 5 ): 754 - 760.
dc.identifier.citedreferenceLevy R. Aging- associated cognitive decline. Working party of the International Psychogeriatric Association in collaboration with the World Health Organization. Int Psychogeriatr. 1994; 6 ( 1 ): 63 - 68.
dc.identifier.citedreferenceGupta A, Mahnken JD, Johnson DK, et al. Prevalence and correlates of cognitive impairment in kidney transplant recipients. BMC Nephrol. 2017; 18 ( 1 ): 158.
dc.identifier.citedreferenceMcadams- Demarco MA, Daubresse M, Bae S, et al. Alzheimer’s disease, and mortality after hemodialysis initiation. Clin. J. Am. Soc. Nephrol. 2018; 13 ( 9 ): 1339 - 1347.
dc.identifier.citedreferenceMcAdams- DeMarco MA, Bae S, Chu N, et al. Dementia and Alzheimer’s disease among older kidney transplant recipients. JASN. 2016.
dc.identifier.citedreferenceAlbert MS, Dekosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging- Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011; 7 ( 3 ): 270 - 279.
dc.identifier.citedreferenceRoberts R, Knopman DS. Classification and epidemiology of MCI. Clin. Geriatr. Med. 2013; 29 ( 4 ).
dc.identifier.citedreferenceSperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging- Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011; 7 ( 3 ): 280 - 292.
dc.identifier.citedreferenceMeyer JS, Xu G, Thornby J, et al. Is mild cognitive impairment prodromal for vascular dementia like Alzheimer’s disease?. Stroke. 2002; 33 ( 8 ): 1981 - 1985.
dc.identifier.citedreferenceJack CR, Knopman DS, Jagust WJ, et al. Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013; 12 ( 2 ): 207 - 216.
dc.identifier.citedreferenceAmjad H, Roth DL, Sheehan OC, et al. Underdiagnosis of dementia: an observational study of patterns in diagnosis and awareness in US older adults. J. Gen. Intern. Med. 2018; 33 ( 7 ): 1131 - 1138.
dc.identifier.citedreferenceHemmelgarn BR, Manns BJ, Quan H, et al. Adapting the Charlson Comorbidity Index for use in patients with ESRD. Am. J. Kidney Dis. 2003; 42 ( 1 ): 125 - 132.
dc.identifier.citedreferenceFried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 2001; 56 ( 3 ): M146 - 156.
dc.identifier.citedreferenceTeng EL, Chui HC. The modified Mini- Mental State (3MS) examination. J. Clin. Psy. 1987; 48 ( 8 ): 314 - 318.
dc.identifier.citedreferenceMcdowell I, Kristjansson B, Hill GB, et al. Community screening for dementia: the mini mental state exam (MMSE) and modified mini- mental state exam (3MS) compared. J. Clin. Epidemiol. 1997; 50 ( 4 ): 377 - 383.
dc.identifier.citedreferenceKurella M, Chertow GM, Luan J, Yaffe K. Cognitive impairment in chronic kidney disease. J. Am. Geriatr. Soc. 2004; 52 ( 11 ): 1863 - 1869.
dc.identifier.citedreferenceKurella M, Chertow GM, Fried LF, et al. Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study. JASN. 2005; 16 ( 7 ): 2127 - 2133.
dc.identifier.citedreferenceEbly EM. Cognitive impairment in the nondemented elderly. Results from the Canadian Study of Health and Aging. Arch Neurol. 1995; 52 ( 6 ): 612 - 619.
dc.identifier.citedreferenceHaugen CE, Mountford A, Warsame F, et al. Incidence, risk factors, and sequelae of post- kidney transplant delirium. JASN. 2018.
dc.identifier.citedreferenceStrauss E, Sherman EM, Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. American Chemical Society; 2006.
dc.identifier.citedreferenceKatz S. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA. 1963; 185: 914 - 919.
dc.identifier.citedreferenceLawton MP, Brody EM. Assessment of older people: self- maintaining and instrumental activities of daily living. The Gerontologist. 1969; 9 ( 3_Part_1 ): 179 - 186.
dc.identifier.citedreferenceChu NM, Bandeen- Roche K, Tian J, et al. Hierarchical development of frailty and cognitive impairment: clues into etiological pathways. J. Gerontol. Series A. 2019.
dc.identifier.citedreferenceYaffe K, Ackerson L, Tamura MK, et al. Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study. J Am Geriatr Soc. 2010; 58 ( 2 ): 338 - 345.
dc.identifier.citedreferenceKurella Tamura M, Xie D, Yaffe K, et al. Vascular risk factors and cognitive impairment in chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study. CJASN. 2011; 6 ( 2 ): 248 - 256.
dc.identifier.citedreferenceKoushik NS, Mcarthur SF, Baird AD. Adult chronic kidney disease: neurocognition in chronic renal failure. Neuropsychol. Rev. 2010; 20 ( 1 ): 33 - 51.
dc.identifier.citedreferenceBuchman AS, Tanne D, Boyle PA, et al. Kidney function is associated with the rate of cognitive decline in the elderly. Neurology. 2009; 73 ( 12 ): 920 - 927.
dc.identifier.citedreferenceSeliger SL, Wendell CR, Waldstein SR, et al. Renal function and long- term decline in cognitive function: the Baltimore Longitudinal Study of Aging. Am. J. Nephrol. 2015; 41 ( 4- 5 ): 305 - 312.
dc.identifier.citedreferenceTamura MK, Larive B, Unruh ML, et al. Prevalence and correlates of cognitive impairment in hemodialysis patients: the frequent hemodialysis network trials. Clin. J. Am. Soc. Nephrol. 2010; 5 ( 8 ): 1429 - 1438.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
ctr14425.pdf
Size:
774.3KB
Format:
PDF
View/Open
Name:
ctr14425_am.pdf
Size:
1.393MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.