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Synaptotagmin- 11 inhibits spontaneous neurotransmission through vti1a
dc.contributor.authorLi, Wan‐ru
dc.contributor.authorWang, Ya‐Long
dc.contributor.authorLi, Chao
dc.contributor.authorGao, Pei
dc.contributor.authorZhang, Fei‐Fan
dc.contributor.authorHu, Meiqin
dc.contributor.authorLi, Jing‐chen
dc.contributor.authorZhang, Shuli
dc.contributor.authorLi, Rena
dc.contributor.authorZhang, Claire Xi
dc.date.accessioned2021-12-02T02:32:13Z
dc.date.available2022-12-01 21:32:12en
dc.date.available2021-12-02T02:32:13Z
dc.date.issued2021-11
dc.identifier.citationLi, Wan‐ru ; Wang, Ya‐Long ; Li, Chao; Gao, Pei; Zhang, Fei‐Fan ; Hu, Meiqin; Li, Jing‐chen ; Zhang, Shuli; Li, Rena; Zhang, Claire Xi (2021). "Synaptotagmin- 11 inhibits spontaneous neurotransmission through vti1a." Journal of Neurochemistry (4): 729-741.
dc.identifier.issn0022-3042
dc.identifier.issn1471-4159
dc.identifier.urihttps://hdl.handle.net/2027.42/171049
dc.description.abstractRecent work has revealed that spontaneous release plays critical roles in the central nervous system, but how it is regulated remains elusive. Here, we report that synaptotagmin- 11 (Syt11), a Ca2+- independent Syt isoform associated with schizophrenia and Parkinson’s disease, suppressed spontaneous release. Syt11- knockout hippocampal neurons showed an increased frequency of miniature excitatory post- synaptic currents while over- expression of Syt11 inversely decreased the frequency. Neither knockout nor over- expression of Syt11 affected the average amplitude, suggesting the pre- synaptic regulation of spontaneous neurotransmission by Syt11. Glutathione S- transferase pull- down, co- immunoprecipitation, and affinity- purification experiments demonstrated a direct interaction of Syt11 with vps10p- tail- interactor- 1a (vti1a), a non- canonical SNARE protein that maintains spontaneous release. Importantly, knockdown of vti1a reversed the phenotype of Syt11 knockout, identifying vti1a as the main target of Syt11 inhibition. Domain analysis revealed that the C2A domain of Syt11 bound vti1a with high affinity. Consistently, expression of the C2A domain alone rescued the phenotype of elevated spontaneous release in Syt11- knockout neurons similar to the full- length protein. Altogether, our results suggest that Syt11 inhibits vti1a- containing vesicles during spontaneous release.Spontaneous neurotransmission plays important roles in the maturation of primeval synapses, post- synaptic signal transduction and synaptic plasticity. Here, we report that synaptotagmin- 11 (Syt11)- knockout in hippocampal neurons increases the frequency of miniature excitatory post- synaptic currents while over- expression reduces it. Mechanistically, Syt11 directly interacts with vps10p- tail- interactor- 1a (vti1a), and knockdown of vti1a reverses the Syt11- knockout phenotype, identifying vti1a as the main target of Syt11 inhibition. The C2A domain of Syt11 binds vti1a with high affinity. Expression of the C2A domain rescues the knockout phenotype similar to full- length Syt11. Altogether, we have identified Syt11 as a novel inhibitor of spontaneous neurotransmission via interaction with vti1a.
dc.publisherWiley Periodicals, Inc.
dc.subject.othervti1a
dc.subject.otherspontaneous release
dc.subject.othersynaptotagmin
dc.subject.otherSNARE
dc.titleSynaptotagmin- 11 inhibits spontaneous neurotransmission through vti1a
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171049/1/jnc15523_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171049/2/jnc15523.pdf
dc.identifier.doi10.1111/jnc.15523
dc.identifier.sourceJournal of Neurochemistry
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