View Item 

Show simple item record

The Relationship Between Frailty and Emotional Health in Older Patients with Advanced Cancer
dc.contributor.authorGilmore, Nikesha
dc.contributor.authorKehoe, Lee
dc.contributor.authorBauer, Jessica
dc.contributor.authorXu, Huiwen
dc.contributor.authorHall, Bianca
dc.contributor.authorWells, Megan
dc.contributor.authorLei, Lianlian
dc.contributor.authorCulakova, Eva
dc.contributor.authorFlannery, Marie
dc.contributor.authorGrossman, Valerie Aarne
dc.contributor.authorSardari, Ronak Amir
dc.contributor.authorSubramanya, Himal
dc.contributor.authorKadambi, Sindhuja
dc.contributor.authorBelcher, Elizabeth
dc.contributor.authorKettinger, Jared
dc.contributor.authorO’Rourke, Mark A.
dc.contributor.authorDib, Elie G.
dc.contributor.authorVogelzang, Nicholas J.
dc.contributor.authorDale, William
dc.contributor.authorMohile, Supriya
dc.date.accessioned2022-01-06T15:51:56Z
dc.date.available2023-01-06 10:51:55en
dc.date.available2022-01-06T15:51:56Z
dc.date.issued2021-12
dc.identifier.citationGilmore, Nikesha; Kehoe, Lee; Bauer, Jessica; Xu, Huiwen; Hall, Bianca; Wells, Megan; Lei, Lianlian; Culakova, Eva; Flannery, Marie; Grossman, Valerie Aarne; Sardari, Ronak Amir; Subramanya, Himal; Kadambi, Sindhuja; Belcher, Elizabeth; Kettinger, Jared; O’Rourke, Mark A.; Dib, Elie G.; Vogelzang, Nicholas J.; Dale, William; Mohile, Supriya (2021). "The Relationship Between Frailty and Emotional Health in Older Patients with Advanced Cancer." The Oncologist 26(12): e2181-e2191.
dc.identifier.issn1083-7159
dc.identifier.issn1549-490X
dc.identifier.urihttps://hdl.handle.net/2027.42/171237
dc.description.abstractBackgroundAging‐related deficits that eventually manifest as frailty may be associated with poor emotional health in older patients with advanced cancer. This study aimed to examine the relationship between frailty and emotional health in this population.MethodsThis was a secondary analysis of baseline data from a nationwide cluster randomized trial. Patients were aged ≥70 years with incurable stage III/IV solid tumors or lymphomas, had ≥1 geriatric assessment (GA) domain impairment, and had completed the Geriatric Depression Scale, Generalized Anxiety Disorder‐7, and Distress Thermometer. Frailty was assessed using a Deficit Accumulation Index (DAI; range 0–1) based on GA, which did not include emotional health variables (depression and anxiety), and participants were stratified into robust, prefrail, and frail categories. Multivariate logistic regression models examined the association of frailty with emotional health outcomes. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were reported.ResultsFive hundred forty‐one patients were included (mean age: 77 years; 70–96). DAI ranged from 0.04 to 0.94; 27% of patients were classified as robust, 42% prefrail, and 31% frail. Compared with robust patients, frail patients had an increased risk of screening positive for depression (aOR = 12.8; 95% CI = 6.1–27.0), anxiety (aOR = 6.6; 95% CI = 2.2–19.7), and emotional distress (aOR = 4.62; 95% CI = 2.9–8.3). Prefrail compared with robust patients also had an increased risk of screening positive for depression (aOR = 2.22; 95% CI = 1.0–4.8) and distress (aOR = 1.71; 95% CI = 1.0–2.8).ConclusionIn older patients with advanced cancer, frailty is associated with poorer emotional health, which indicates a need for an integrated care approach to treating these patients.Implications for PracticeA relationship exists between frailty and poor emotional health in older adults with advanced cancer. Identifying areas of frailty can prompt screening for emotional health and guide delivery of appropriate interventions. Alternatively, attention to emotional health may also improve frailty.Frailty is an aging‐related syndrome. This article examines the relationship between frailty and emotional health in older patients with advanced cancer.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otherDistress
dc.subject.otherDepression
dc.subject.otherFrailty
dc.subject.otherEmotional health
dc.subject.otherGeriatric assessment
dc.subject.otherAnxiety
dc.titleThe Relationship Between Frailty and Emotional Health in Older Patients with Advanced Cancer
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelHematology and Oncology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171237/1/onco13975.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171237/2/onco13975_am.pdf
dc.identifier.doi10.1002/onco.13975
dc.identifier.sourceThe Oncologist
dc.identifier.citedreferenceHernandez Torres C, Hsu T. Comprehensive geriatric assessment in the older adult with cancer: A review. Eur Urol Focus 2017; 3: 330 – 339.
dc.identifier.citedreferenceUnutzer J, Patrick DL, Simon G et al. Depressive symptoms and the cost of health services in HMO patients aged 65 years and older. A 4‐year prospective study. JAMA 1997; 277: 1618 – 1623.
dc.identifier.citedreferenceDruss BG, Rohrbaugh RM, Rosenheck RA. Depressive symptoms and health costs in older medical patients. Am J Psychiatry 1999; 156: 477 – 479.
dc.identifier.citedreferenceLanga KM, Valenstein MA, Fendrick AM et al. Extent and cost of informal caregiving for older Americans with symptoms of depression. Am J Psychiatry 2004; 161: 857 – 863.
dc.identifier.citedreferenceGallo JJ, Anthony JC, Muthen BO. Age differences in the symptoms of depression: A latent trait analysis. J Gerontol 1994; 49: P251 – P264.
dc.identifier.citedreferenceKissane DW, Maj M, Sartorius N. Depression and cancer. Chichester, West Sussex, UK: Wiley, 2011:xiv, 244 p.
dc.identifier.citedreferenceWeinberger MI, Roth AJ, Nelson CJ. Untangling the complexities of depression diagnosis in older cancer patients. The Oncologist 2009; 14: 60 – 66.
dc.identifier.citedreferenceSaracino RM, Weinberger MI, Roth AJ et al. Assessing depression in a geriatric cancer population. Psychooncology 2017; 26: 1484 – 1490.
dc.identifier.citedreferenceKlepin HD, Tooze JA, Pardee TS et al. Effect of intensive chemotherapy on physical, cognitive, and emotional health of older adults with acute myeloid leukemia. J Am Geriatr Soc 2016; 64: 1988 – 1995.
dc.identifier.citedreferenceNelson CJ, Balk EM, Roth AJ. Distress, anxiety, depression, and emotional well‐being in African‐American men with prostate cancer. Psychooncology 2010; 19: 1052 – 1060.
dc.identifier.citedreferenceTeunissen SC, de Haes HC, Voest EE et al. Does age matter in palliative care? Crit Rev Oncol Hemat 2006; 60: 152 – 158.
dc.identifier.citedreferenceTrevino KM, Saracino RM, Roth AJ. Symptomatology, assessment, and treatment of anxiety in older adults with cancer. J Geriatr Oncol 2021; 12: 316 – 319.
dc.identifier.citedreferenceChan CMH, Ahmad WAW, Yusof MMD et al. Effects of depression and anxiety on mortality in a mixed cancer group: A longitudinal approach using standardised diagnostic interviews. Psychooncology 2015; 24: 718 – 725.
dc.identifier.citedreferenceDelgado‐Guay M, Parsons HA, Li Z et al. Symptom distress in advanced cancer patients with anxiety and depression in the palliative care setting. Support Care Cancer 2009; 17: 573 – 579.
dc.identifier.citedreferenceSmith EM, Gomm SA, Dickens CM. Assessing the independent contribution to quality of life from anxiety and depression in patients with advanced cancer. Palliat Med 2003; 17: 509 – 513.
dc.identifier.citedreferenceHurria A, Li D, Hansen K et al. Distress in older patients with cancer. J Clin Oncol 2009; 27: 4346 – 4351.
dc.identifier.citedreferenceSousa ACPD, Dias RC, Maciel ACC et al. Frailty syndrome and associated factors in community‐dwelling elderly in northeast Brazil. Arch Gerontol Geriat 2012; 54: E95 – E101.
dc.identifier.citedreferenceGurina NA, Frolova EV, Degryse JM. A roadmap of aging in Russia: The prevalence of frailty in community‐dwelling older adults in the St. Petersburg district‐the "crystal" study. J Am Geriatr Soc 2011; 59: 980 – 988.
dc.identifier.citedreferencePegorari MS, Tavares DMD. Factors associated with the frailty syndrome in elderly individuals living in the urban area. Rev Lat Am Enfermagem 2014; 22: 874 – 882.
dc.identifier.citedreferenceMohile SG, Epstein RM, Hurria A et al. Communication with older patients with cancer using geriatric assessment: A cluster‐randomized clinical trial from the national cancer institute community oncology research program. JAMA Oncol 2020; 6: 196 – 204.
dc.identifier.citedreferenceLoh KP, Mohile SG, Lund JL et al. Beliefs about advanced cancer curability in older patients, their caregivers, and oncologists. The Oncologist 2019; 24: E292 – E302.
dc.identifier.citedreferenceSearle SD, Mitnitski A, Gahbauer EA et al. A standard procedure for creating a frailty index. BMC Geriatr 2008; 8: 24.
dc.identifier.citedreferenceLoh KP, Soto‐Perez‐de‐Celis E, Hsu T et al. What every oncologist should know about geriatric assessment for older patients with cancer: Young International Society of Geriatric Oncology position paper. J Oncol Pract 2018; 14: 85 – 94.
dc.identifier.citedreferenceGreenberg SA. The geriatric depression scale (GDS). Hartford Institute for Geriatric Nursing, NYU College of Nursing 2012: 2. Available at https://hign.org/consultgeri/try-this-series/geriatric-depression-scale-gds. Accessed April 12,2020.
dc.identifier.citedreferenceWild B, Eckl A, Herzog W et al. Assessing generalized anxiety disorder in elderly people using the GAD‐7 and GAD‐2 scales: Results of a validation study. Am J Geriat Psychiat 2014; 22: 1029 – 1038.
dc.identifier.citedreferenceCohen HJ, Smith D, Sun CL et al. Frailty as determined by a comprehensive geriatric assessment‐derived deficit‐accumulation index in older patients with cancer who receive chemotherapy. Cancer 2016; 122: 3865 – 3872.
dc.identifier.citedreferenceAkaike H. Citation classic ‐ a new look at the statistical‐model identification. Cc/Eng Tech Appl Sci 1981; 51: 22.
dc.identifier.citedreferenceAtkinson AC. Likelihood ratios, posterior odds and information criteria. J Econometrics 1981; 16: 15 – 20.
dc.identifier.citedreferenceShtatland ES, Kleinman K & Cain EM Stepwise methods in using SAS Proc Logistic and SAS Enterpise Miner for prediction. SUGI 28;Paper 258‐28
dc.identifier.citedreferenceJeste DV. Frailty and mental health: Association with cognition, sleep, and well‐being in older adults. Int Psychogeriatr 2019; 31: 755 – 757.
dc.identifier.citedreferenceBuigues C, Padilla‐Sanchez C, Garrido JF et al. The relationship between depression and frailty syndrome: A systematic review. Aging Ment Health 2015; 19: 762 – 772.
dc.identifier.citedreferenceWang XH, Shen KJ. The reciprocal relationship between frailty and depressive symptoms among older adults in rural China: A cross‐lag analysis. Healthcare (Basel) 2021; 9: 593.
dc.identifier.citedreferenceDe Vriendt P, Peersman W, Florus A et al. Improving health related quality of life and independence in community dwelling frail older adults through a client‐centred and activity‐oriented program. A pragmatic randomized controlled trial. J Nutr Health Aging 2016; 20: 35 – 40.
dc.identifier.citedreferenceApostolo J, Cooke R, Bobrowicz‐Campos E et al. Effectiveness of interventions to prevent pre‐frailty and frailty progression in older adults: A systematic review. JBI Database System Rev Implement Rep 2018; 16: 140 – 232.
dc.identifier.citedreferenceCohen HJ, Feussner JR, Weinberger M et al. A controlled trial of inpatient and outpatient geriatric evaluation and management. New Engl J Med 2002; 346: 905 – 912.
dc.identifier.citedreferenceMonteserin R, Brotons C, Moral I et al. Effectiveness of a geriatric intervention in primary care: A randomized clinical trial. Fam Pract 2010; 27: 239 – 245.
dc.identifier.citedreferenceMagnuson A, Allore H, Cohen HJ et al. Geriatric assessment with management in cancer care: Current evidence and potential mechanisms for future research. J Geriatr Oncol 2016; 7: 242 – 248.
dc.identifier.citedreferenceRodin G, An E, Shnall J et al. Psychological interventions for patients with advanced disease: Implications for oncology and palliative care. J Clin Oncol 2020; 38: 885 – 904.
dc.identifier.citedreferenceFaller H, Schuler M, Richard M et al. Effects of psycho‐oncologic interventions on emotional distress and quality of life in adult patients with cancer: Systematic review and meta‐analysis. J Clin Oncol 2013; 31: 782 – 793.
dc.identifier.citedreferenceMohile SG, Dale W, Somerfield MR et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology. J Clin Oncol 2018; 36: 2326 – 2347.
dc.identifier.citedreferenceWalston J, Buta B, Xue QL. Frailty screening and interventions: Considerations for clinical practice. Clin Geriatr Med 2018; 34: 25 – 38.
dc.identifier.citedreferenceHurria A, Li DN, Hansen K et al. Distress in older patients with cancer. J Clin Oncol 2009; 27: 4346 – 4351.
dc.identifier.citedreferenceRockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 2007; 62: 722 – 727.
dc.identifier.citedreferenceRockwood K, Howlett SE. Age‐related deficit accumulation and the diseases of ageing. Mech Ageing Dev 2019; 180: 107 – 116.
dc.identifier.citedreferenceSong X, Mitnitski A, Rockwood K. Prevalence and 10‐year outcomes of frailty in older adults in relation to deficit accumulation. J Am Geriatr Soc 2010; 58: 681 – 687.
dc.identifier.citedreferenceHandforth C, Clegg A, Young C et al. The prevalence and outcomes of frailty in older cancer patients: A systematic review. Ann Oncol 2015; 26: 1091 – 1101.
dc.identifier.citedreferenceKojima G, Iliffe S, Jivraj S et al. Association between frailty and quality of life among community‐dwelling older people: A systematic review and meta‐analysis. J Epidemiol Community Health 2016; 70: 716 – 721.
dc.identifier.citedreferenceRockwood K, Stadnyk K, MacKnight C et al. A brief clinical instrument to classify frailty in elderly people. Lancet 1999; 353: 205 – 206.
dc.identifier.citedreferenceEthun CG, Bilen MA, Jani AB et al. Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology. CA Cancer J Clin 2017; 67: 362 – 377.
dc.identifier.citedreferenceMandelblatt JS, Cai L, Luta G et al. Frailty and long‐term mortality of older breast cancer patients: CALGB 369901 (Alliance). Breast Cancer Res Treat 2017; 164: 107 – 117.
dc.identifier.citedreferenceWilliams GR, Deal AM, Sanoff HK et al. Frailty and health‐related quality of life in older women with breast cancer. Support Care Cancer 2019; 27: 2693 – 2698.
dc.identifier.citedreferenceWeiss Wiesel TR, Nelson CJ, Tew WP et al. The relationship between age, anxiety, and depression in older adults with cancer. Psychooncology 2015; 24: 712 – 717.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
onco13975.pdf
Size:
764.5KB
Format:
PDF
View/Open
Name:
onco13975_am.pdf
Size:
802.7KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.