View Item 

Show simple item record

Surgical evaluation in children <3 years of age with drug- resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays
dc.contributor.authorPerry, Michael Scott
dc.contributor.authorShandley, Sabrina
dc.contributor.authorPerelman, Max
dc.contributor.authorSingh, Rani K.
dc.contributor.authorWong-Kisiel, Lily
dc.contributor.authorSullivan, Joseph
dc.contributor.authorGonzalez-Giraldo, Ernesto
dc.contributor.authorRomanowski, Erin Fedak
dc.contributor.authorMcNamara, Nancy A.
dc.contributor.authorMarashly, Ahmad
dc.contributor.authorOstendorf, Adam P.
dc.contributor.authorAlexander, Allyson
dc.contributor.authorEschbach, Krista
dc.contributor.authorBolton, Jeffrey
dc.contributor.authorWolf, Steven
dc.contributor.authorMcGoldrick, Patricia
dc.contributor.authorDepositario-Cabacar, Dewi F.
dc.contributor.authorCiliberto, Michael A.
dc.contributor.authorGedela, Satyanarayana
dc.contributor.authorSannagowdara, Kumar
dc.contributor.authorKaria, Samir
dc.contributor.authorShrey, Daniel W.
dc.contributor.authorTatachar, Priya
dc.contributor.authorNangia, Srishti
dc.contributor.authorGrinspan, Zachary
dc.contributor.authorReddy, Shilpa B.
dc.contributor.authorShital, Patel
dc.contributor.authorCoryell, Jason
dc.date.accessioned2022-02-07T20:21:51Z
dc.date.available2023-02-07 15:21:50en
dc.date.available2022-02-07T20:21:51Z
dc.date.issued2022-01
dc.identifier.citationPerry, Michael Scott; Shandley, Sabrina; Perelman, Max; Singh, Rani K.; Wong-Kisiel, Lily ; Sullivan, Joseph; Gonzalez-Giraldo, Ernesto ; Romanowski, Erin Fedak; McNamara, Nancy A.; Marashly, Ahmad; Ostendorf, Adam P.; Alexander, Allyson; Eschbach, Krista; Bolton, Jeffrey; Wolf, Steven; McGoldrick, Patricia; Depositario-Cabacar, Dewi F. ; Ciliberto, Michael A.; Gedela, Satyanarayana; Sannagowdara, Kumar; Karia, Samir; Shrey, Daniel W.; Tatachar, Priya; Nangia, Srishti; Grinspan, Zachary; Reddy, Shilpa B.; Shital, Patel; Coryell, Jason (2022). "Surgical evaluation in children <3 years of age with drug- resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays." Epilepsia (1): 96-107.
dc.identifier.issn0013-9580
dc.identifier.issn1528-1167
dc.identifier.urihttps://hdl.handle.net/2027.42/171513
dc.description.abstractObjectiveDrug- resistant epilepsy (DRE) occurs at higher rates in children <3 years old. Epilepsy surgery is effective, but rarely utilized in young children despite developmental benefits of early seizure freedom. The present study aims to identify unique patient characteristics and evaluation strategies in children <3 years old who undergo epilepsy surgery evaluation as a means to assess contributors and potential solutions to health care disparities in this group.MethodsThe Pediatric Epilepsy Research Consortium Epilepsy Surgery Database, a multicentered, cross- sectional collaboration of 21 US pediatric epilepsy centers, collects prospective data on children <18 years of age referred for epilepsy surgery evaluation. We compared patient characteristics, diagnostic utilization, and surgical treatment between children <3 years old and those older undergoing initial presurgical evaluation. We evaluated patient characteristics leading to delayed referral (>1 year) after DRE diagnosis in the very young.ResultsThe cohort included 437 children, of whom 71 (16%) were <3 years of age at referral. Children evaluated before the age of 3 years more commonly had abnormal neurological examinations (p = .002) and daily seizures (p = .001). At least one ancillary test was used in 44% of evaluations. Fifty- nine percent were seizure- free following surgery (n = 34), with 35% undergoing limited focal resections. Children with delayed referrals more often had focal aware (p < .001) seizures and recommendation for palliative surgeries (p < .001).SignificanceThere are relatively few studies of epilepsy surgery in the very young. Surgery is effective, but may be disproportionally offered to those with severe presentations. Relatively low utilization of ancillary testing may contribute to reduced surgical therapy for those without evident lesions on magnetic resonance imaging. Despite this, a sizeable portion of patients have favorable outcome after focal epilepsy surgery resections.
dc.publisherWiley Periodicals, Inc.
dc.publisherRaven Press
dc.subject.otherchildhood epilepsy
dc.subject.otherepilepsy surgery
dc.subject.otherpharmacoresistant
dc.titleSurgical evaluation in children <3 years of age with drug- resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171513/1/epi17124.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171513/2/epi17124_am.pdf
dc.identifier.doi10.1111/epi.17124
dc.identifier.sourceEpilepsia
dc.identifier.citedreferenceAabert KM, Gunnes N, Bakken IJ, Søraas CL, Berntsen A, Magnus P, et al. Incidence and prevalence of childhood epilepsy: a nationwide cohort study. Pediatrics. 2017; 139: 1 - 9.
dc.identifier.citedreferenceCamfield CS, Camfield PR, Gordon K, Wirrell E, Dooley JM. Incidence of epilepsy in childhood and adolescence: a population- based study in Nova Scotia from 1977 to 1985. Epilepsia. 1996; 37: 19 - 23.
dc.identifier.citedreferencePulsifer MB, Brandt J, Salorio CF, Vining EPG, Carson BS, Freeman JM. The cognitive outcome of hemispherectomy in 71 children. Epilepsia. 2004; 45: 243 - 54.
dc.identifier.citedreferenceRoberts JI, Hrazdil C, Wiebe S, Sauro K, Hanson A, Federico P, et al. Feasibility of using an online tool to assess appropriateness for an epilepsy surgery evaluation. Neurology. 2014; 83: 913 - 9.
dc.identifier.citedreferenceJenny B, Smoll N, El Hassani Y, Momjian S, Pollo C, Korff CM, et al. Pediatric epilepsy surgery: could age be a predictor of outcomes? J Neurosurg Pediatr. 2016; 18: 235 - 41.
dc.identifier.citedreferenceDuchowny M, Jayakar P, Resnick T, Harvey AS, Alvarez L, Dean P, et al. Epilepsy surgery in the first three years of life. Epilepsia. 1998; 39: 737 - 43.
dc.identifier.citedreferenceBaud MO, Perneger T, Racz A, Pensel MC, Elger C, Rydenhag B, et al. European trends in epilepsy surgery. Neurology. 2018; 91: 96 - 106.
dc.identifier.citedreferenceWirrell E, Wong- Kisiel L, Mandrekar J, Nickels K. Predictors and course of medically intractable epilepsy in young children presenting before 36 months of age: a retrospective, population- based study. Epilepsia. 2012; 53: 1563 - 9.
dc.identifier.citedreferenceBerg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, et al. Immediate outcomes in early life epilepsy: a contemporary account. Epilepsy Behav. 2019; 97: 44 - 50.
dc.identifier.citedreferenceBerg AT, Zelko FA, Levy SR, Testa FM. Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes: a prospective cohort study. Neurology. 2012; 79: 1384 - 91.
dc.identifier.citedreferenceVignoli A, Peron A, Turner K, Scornavacca GF, La Briola F, Chiesa V, et al. Long- term outcome of epilepsy with onset in the first three years of life: findings from a large cohort of patients. Eur J Paediatr Neurol. 2016; 20: 566 - 72.
dc.identifier.citedreferenceWirrell EC, Grossardt BR, Wong- Kisiel LC, Nickels KC. Incidence and classification of new- onset epilepsy and epilepsy syndromes in children in Olmsted County, Minnesota from 1980 to 2004: a population- based study. Epilepsy Res. 2011; 95: 110 - 8.
dc.identifier.citedreferenceKim LH, Parker JJ, Ho AL, Pendharkar AV, Sussman ES, Halpern CH, et al. Postoperative outcomes following pediatric intracranial electrode monitoring: a case for stereoelectroencephalography (SEEG). Epilepsy Behav. 2020; 104 ( pt A ): 106905.
dc.identifier.citedreferenceLiu Y, Chen G, Chen J, Zhou J, Su L, Zhao T, et al. Individualized stereoelectroencephalography evaluation and navigated resection in medically refractory pediatric epilepsy. Epilepsy Behav. 2020; 112: 107398.
dc.identifier.citedreferenceTaussig D, Chipaux M, Fohlen M, Dorison N, Bekaert O, Ferrand- Sorbets S, et al. Invasive evaluation in children (SEEG vs subdural grids). Seizure. 2020; 77: 43 - 51.
dc.identifier.citedreferenceTaussig D, Dorfmüller G, Fohlen M, Jalin C, Bulteau C, Ferrand- Sorbets S, et al. Invasive explorations in children younger than 3 years. Seizure. 2012; 21: 631 - 8.
dc.identifier.citedreferenceKarsonovich T, Alexander A, Graber S, O’Neil BR. Placement of leads for stereotactic electroencephalography without the use of anchor bolts: technical note. J Neurosurg Pediatr. 2020; 18: 1 - 6.
dc.identifier.citedreferenceGracia CG, Yardi R, Kattan MW, Nair D, Gupta A, Najm I, et al. Seizure freedom score: a new simple method to predict success of epilepsy surgery. Epilepsia. 2015; 56: 359 - 565.
dc.identifier.citedreferenceFreitag H, Tuxhorn I. Cognitive function in preschool children after epilepsy surgery: rationale for early intervention. Epilepsia. 2005; 46 ( 4 ): 561 - 7.
dc.identifier.citedreferenceEngel J, Van Ness P, Rasmussen T, Ojemann I. Outcome with respect to epileptic seizures. In: Engel J Jr, editor. Surgical treatment of the epilepsies. 2 nd ed. New York, NY: Raven Press; 1993. p. 609 - 21.
dc.identifier.citedreferenceFisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017; 58 ( 4 ): 522 - 30.
dc.identifier.citedreferenceHarris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O- Neal L, et al. The REDCap consortium: building an international community of software partners. J Biomed Inform. 2019; 95: 103208.
dc.identifier.citedreferenceHarris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)- a metadata- driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009; 42 ( 2 ): 377 - 81.
dc.identifier.citedreferenceCoryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, et al. Neuroimaging of early life epilepsy. Pediatrics. 2018; 142:e20180672.
dc.identifier.citedreferenceWyllie E, Comair YG, Kotagal P, Raja S, Ruggieri P. Epilepsy surgery in infants. Epilepsia. 1996; 37: 625 - 37.
dc.identifier.citedreferenceSugimoto T, Otsubo H, Hwang PA, Hoffman HJ, Jay V, Snead OC III. Outcome of epilepsy surgery in the first three years of life. Epilepsia. 1999; 40: 560 - 5.
dc.identifier.citedreferenceDunkley C, Kung J, Scott RC, Nicolaides P, Neville B, Aylett SE, et al. Epilepsy surgery in children under 3 years. Epilepsy Res. 2011; 93: 96 - 106.
dc.identifier.citedreferenceGowda S, Salazar F, Bingaman WE, Kotagal P, Lachhwani DL, Gupta A, et al. Surgery for catastrophic epilepsy in infants 6 months of age and younger. J Neurosurg Pediatrics. 2010; 5: 603 - 7.
dc.identifier.citedreferencePindrik J, Hoang N, Smith L, Halverson M, Wojnaroski M, McNally K, et al. Preoperative evaluation and surgical management of infants and toddlers with drug- resistant epilepsy. Neurosurg Focus. 2018; 45: 1 - 12.
dc.identifier.citedreferenceLoddenkemper T, Holland KD, Stanford LD, Kotagal P, Bingaman W, Wyllie E. Developmental outcome after epilepsy surgery in infancy. Pediatrics. 2007; 119: 930 - 5.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
epi17124.pdf
Size:
634.6KB
Format:
PDF
View/Open
Name:
epi17124_am.pdf
Size:
210.4KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.