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Biodegradable Polymer with Effective Near‐Infrared‐II Absorption as a Photothermal Agent for Deep Tumor Therapy

dc.contributor.authorYu, Yingjie
dc.contributor.authorTang, Dongsheng
dc.contributor.authorLiu, Chaoyong
dc.contributor.authorZhang, Qi
dc.contributor.authorTang, Lin
dc.contributor.authorLu, Yunfeng
dc.contributor.authorXiao, Haihua
dc.date.accessioned2022-02-07T20:22:14Z
dc.date.available2023-02-07 15:22:13en
dc.date.available2022-02-07T20:22:14Z
dc.date.issued2022-01
dc.identifier.citationYu, Yingjie; Tang, Dongsheng; Liu, Chaoyong; Zhang, Qi; Tang, Lin; Lu, Yunfeng; Xiao, Haihua (2022). "Biodegradable Polymer with Effective Near‐Infrared‐II Absorption as a Photothermal Agent for Deep Tumor Therapy." Advanced Materials 34(4): n/a-n/a.
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.urihttps://hdl.handle.net/2027.42/171524
dc.description.abstractPhotothermal therapy holds great promise for cancer treatment due to its effective tumor ablation and minimal invasiveness. Herein a new class of biodegradable photothermal agents with effective adsorption in both near‐infrared‐I (NIR‐I) and NIR‐II windows is reported for deep tumor therapy. As demonstrated in a deep‐seated ovarian cancer model, photothermal therapy using 1064 nm irradiation effectively inhibits tumor progression and prolongs survival spans. This work provides a new design of photothermal agents toward a more effective therapy of tumors.A biodegradable photothermal agent is developed by inserting cleavable disulfide moieties into a conjugative polymer, which affords biodegradability and excellent adsorption in both the near‐infrared (NIR)‐I and NIR‐II windows, effectively inhibits tumor progression, and extends survival spans in a deep‐seated ovarian cancer mouse model.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherNIR‐II window
dc.subject.otherovarian cancer model
dc.subject.otherphotothermal agents
dc.subject.otherphotothermal therapy
dc.subject.otherbiodegradability
dc.titleBiodegradable Polymer with Effective Near‐Infrared‐II Absorption as a Photothermal Agent for Deep Tumor Therapy
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelEngineering (General)
dc.subject.hlbsecondlevelMaterials Science and Engineering
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171524/1/adma202105976.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171524/2/adma202105976_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171524/3/adma202105976-sup-0001-SuppMat.pdf
dc.identifier.doi10.1002/adma.202105976
dc.identifier.sourceAdvanced Materials
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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