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Cytologic features of small cell melanoma

dc.contributor.authorSatturwar, Swati
dc.contributor.authorPantanowitz, Liron
dc.contributor.authorPatel, Rajiv M.
dc.contributor.authorCantley, Richard
dc.date.accessioned2022-02-07T20:25:02Z
dc.date.available2023-03-07 15:24:59en
dc.date.available2022-02-07T20:25:02Z
dc.date.issued2022-02
dc.identifier.citationSatturwar, Swati; Pantanowitz, Liron; Patel, Rajiv M.; Cantley, Richard (2022). "Cytologic features of small cell melanoma." Diagnostic Cytopathology 50(2): E63-E70.
dc.identifier.issn8755-1039
dc.identifier.issn1097-0339
dc.identifier.urihttps://hdl.handle.net/2027.42/171591
dc.description.abstractSmall cell melanoma (SCM) is an aggressive variant of malignant melanoma (MM), which has been rarely described in the cytology literature. The aim of this study was to describe the clinical and cytologic features of a series of cases of metastatic SCM with discussion of the differential diagnosis of metastatic SCM diagnosed by fine‐needle aspiration (FNA). A retrospective review of cases was performed, identifying two FNA cases and one core biopsy with touch preparation of metastatic SCM. Clinical presentation, cytomorphology features, ancillary tests, and final diagnoses were documented and analyzed. Patients ranged in age from 69 to 85 years‐old. Cytomorphologic features included the presence of a monomorphic population of dispersed small round blue cells, with scant cytoplasm, high nuclear to cytoplasmic ratios, dense nuclear chromatin, and inconspicuous nucleoli. Acinar like arrangement (n = 2) and nuclear molding (n = 1) were also present. All cases showed diffuse positivity for the melanocytic markers SOX10 and Melan A by immunohistochemistry (IHC). Expression of neuroendocrine markers was variable. Diagnosing metastatic SCM at unusual anatomic sites by FNA cytology is a challenging task, especially in patients without known prior history of melanoma. Cytomorphology of SCM is unique, differing from conventional MM in many aspects, including the presence of acinar formations and a lack of typical melanoma features, such as large cells, intracytoplasmic melanin, and macronucleoli. IHC is critical for establishing the diagnosis of SCM.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otherfine‐needle aspiration
dc.subject.othermalignant melanoma
dc.subject.othermetastatic melanoma
dc.subject.othersmall cell melanoma
dc.subject.othertouch preparation
dc.subject.othercytomorphology
dc.titleCytologic features of small cell melanoma
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPathology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171591/1/dc24889_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171591/2/dc24889.pdf
dc.identifier.doi10.1002/dc.24889
dc.identifier.sourceDiagnostic Cytopathology
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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