View Item 

Show simple item record

Advancing Clinical Trials in Nursing Homes: A Proposed Roadmap to Success
dc.contributor.authorGurwitz, Jerry H.
dc.contributor.authorQuinn, Charlene C.
dc.contributor.authorAbi-Elias, Ivan H.
dc.contributor.authorAdams, Alyce S.
dc.contributor.authorBartel, Rosie
dc.contributor.authorBonner, Alice
dc.contributor.authorBoxer, Rebecca
dc.contributor.authorDelude, Christopher
dc.contributor.authorGifford, David
dc.contributor.authorHanson, Bruce
dc.contributor.authorIto, Kouta
dc.contributor.authorJain, Paavani
dc.contributor.authorMagaziner, Jay S.
dc.contributor.authorMazor, Kathleen M.
dc.contributor.authorMitchell, Susan L.
dc.contributor.authorMody, Lona
dc.contributor.authorNace, David
dc.contributor.authorOuslander, Joseph
dc.contributor.authorReifsnyder, Jo Anne
dc.contributor.authorResnick, Barbara
dc.contributor.authorZimmerman, Sheryl
dc.date.accessioned2022-04-08T18:02:56Z
dc.date.available2023-04-08 14:02:55en
dc.date.available2022-04-08T18:02:56Z
dc.date.issued2022-03
dc.identifier.citationGurwitz, Jerry H.; Quinn, Charlene C.; Abi-Elias, Ivan H. ; Adams, Alyce S.; Bartel, Rosie; Bonner, Alice; Boxer, Rebecca; Delude, Christopher; Gifford, David; Hanson, Bruce; Ito, Kouta; Jain, Paavani; Magaziner, Jay S.; Mazor, Kathleen M.; Mitchell, Susan L.; Mody, Lona; Nace, David; Ouslander, Joseph; Reifsnyder, Jo Anne; Resnick, Barbara; Zimmerman, Sheryl (2022). "Advancing Clinical Trials in Nursing Homes: A Proposed Roadmap to Success." Journal of the American Geriatrics Society 70(3): 701-708.
dc.identifier.issn0002-8614
dc.identifier.issn1532-5415
dc.identifier.urihttps://hdl.handle.net/2027.42/171993
dc.description.abstractAn effective clinical research effort in nursing homes to address prevention and treatment of COVID‐19 faced overwhelming challenges. Under the Health Care Systems Research Network‐Older Americans Independence Centers AGING Initiative, a multidisciplinary Stakeholder Advisory Panel was convened to develop recommendations to improve the capability of the clinical research enterprise in US nursing homes. The Panel considered the nursing home as a setting for clinical trials, reviewed the current state of clinical trials in nursing homes, and ultimately developed recommendations for the establishment of a nursing home clinical trials research network that would be centrally supported and administered. This report summarizes the Panel’s recommendations, which were developed in alignment with the following core principles: build on available research infrastructure where appropriate; leverage existing productive partnerships of researchers with groups of nursing homes and nursing home corporations; encompass both efficacy and effectiveness clinical trials; be responsive to a broad range of stakeholders including nursing home residents and their care partners; be relevant to an expansive range of clinical and health care delivery research questions; be able to pivot as necessary to changing research priorities and circumstances; create a pathway for industry‐sponsored research as appropriate; invest in strategies to increase diversity in study populations and the research workforce; and foster the development of the next generation of nursing home researchers.See related editorial by Zimmerman et al. and Special Articles by Levy et al. and Resnick et al. in this issue.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otherpandemic
dc.subject.otherclinical trials
dc.subject.otherCOVID‐19
dc.subject.otherlong‐term care
dc.subject.othernursing homes
dc.titleAdvancing Clinical Trials in Nursing Homes: A Proposed Roadmap to Success
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelGeriatrics
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171993/1/jgs17696.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/171993/2/jgs17696_am.pdf
dc.identifier.doi10.1111/jgs.17696
dc.identifier.sourceJournal of the American Geriatrics Society
dc.identifier.citedreferenceGottlieb S. The need for a US national clinical trial infrastructure in a public health crisis. JAMA Health Forum. 2021; 2: e213223.
dc.identifier.citedreferenceSimmons S, Resnick B, Schnelle J, Ouslander JG. Clinical trials in nursing homes: challenges and practical solutions. In: Cherubini A, Bernabei R, Ferrucci L, Marchionni N, Studenski S, Vellas B, eds. Clinical Trials in Older Adults. John Wiley; 2015: 231 ‐ 253.
dc.identifier.citedreferenceQuinn CC, Adams AS, Magaziner JS, Gurwitz JH. Coronavirus disease 2019 and clinical research in U.S. nursing homes. J Am Geriatr Soc. 2021; 69: 1748 ‐ 1751.
dc.identifier.citedreferenceGurwitz JH, Bonner A. Nursing homes, the pandemic, and caring enough. J Gen Intern Med. 2020; 35: 2752 ‐ 2754.
dc.identifier.citedreferenceAngus DC, Gordon AC, Bauchner H. Emerging lessons from COVID‐19 for the US clinical research enterprise. JAMA. 2021; 325: 1159 ‐ 1161.
dc.identifier.citedreferenceCohen MS, Nirula A, Mulligan MJ, et al. Effect of bamlanivimab vs placebo on incidence of COVID‐19 among residents and staff of skilled nursing and assisted living facilities: a randomized clinical trial. JAMA. 2021; 326: 46 ‐ 55.
dc.identifier.citedreferenceBernard MA, Clayton JA, Lauer MS. Inclusion across the lifespan: NIH policy for clinical research. JAMA. 2018; 320: 1535 ‐ 1536.
dc.identifier.citedreferenceSteinman MA, Boyd CM, Schmader KE. Expanding evidence for clinical care of older adults: beyond clinical trial traditions and finding new approaches. JAMA. 2021; 326: 475 ‐ 476.
dc.identifier.citedreferenceVerdoorn BP, Evans TK, Hanson GJ, et al. Fisetin for COVID‐19 in skilled nursing facilities: Senolytic trials in the COVID era. J Am Geriatr Soc. 2021; 69: 3023 ‐ 3033.
dc.identifier.citedreferenceOuslander JG, Schnelle JF. Research in nursing homes: practical aspects. J Am Geriatr Soc. 1993; 41: 182 ‐ 187.
dc.identifier.citedreferenceStriving for Diversity in Research Studies. N Engl J Med. 2021; 385: 1429 ‐ 1430.
dc.identifier.citedreferenceSierra F, Caspi A, Fortinsky RH, et al. Moving geroscience from the bench to clinical care and health policy. J Am Geriatr Soc. 2021; 69: 2455 ‐ 2463.
dc.identifier.citedreferenceTisminetzky M, Bayliss EA, Magaziner JS, et al. Research priorities to advance the health and health care of older adults with multiple chronic conditions. J Am Geriatr Soc. 2017; 65: 1549 ‐ 1553.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
jgs17696.pdf
Size:
606.2KB
Format:
PDF
View/Open
Name:
jgs17696_am.pdf
Size:
327.1KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.