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Cortico‐striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs
dc.contributor.authorHengenius, James B.
dc.contributor.authorBohnen, Nicolaas I.
dc.contributor.authorRosso, Andrea
dc.contributor.authorHuppert, Theodore J.
dc.contributor.authorRosano, Caterina
dc.date.accessioned2022-04-08T18:07:09Z
dc.date.available2023-04-08 14:07:07en
dc.date.available2022-04-08T18:07:09Z
dc.date.issued2022-03
dc.identifier.citationHengenius, James B.; Bohnen, Nicolaas I.; Rosso, Andrea; Huppert, Theodore J.; Rosano, Caterina (2022). "Cortico‐striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs." Journal of Neuroimaging 32(2): 352-362.
dc.identifier.issn1051-2284
dc.identifier.issn1552-6569
dc.identifier.urihttps://hdl.handle.net/2027.42/172077
dc.description.abstractBackground and PurposeMild Parkinsonian signs (MPS) are common in older adults. We hypothesized that MPS are associated with lower functional connectivity (FC) in dopamine‐dependent cortico‐striatal networks, and these associations vary with white matter hyperintensity (WMH), a risk factor for MPS.MethodsWe examined resting‐state functional MRI in 266 participants (mean age 83; 57% female; 41% African American) with data on MPS (Unified Parkinson’s Disease Rating Scale), demographics, cognition, muscle‐skeletal, and cardiometabolic health. FC between cortex and striatum was examined separately for sensorimotor, executive, and limbic functional subregions. Logistic regression tested the association of FC in each network with MPS, adjusted for covariates. Interactions of FC by WMH were tested; and analyses were repeated stratified by WMH above/below the median.ResultsCompared to those without MPS, those with MPS had lower cortico‐striatal FC in the left executive network (adjusted odds ratio [95% confidence interval], p‐value: 0.188 [0.043, 0.824], .027). The interaction with WMH was p = .064; left executive FC was inversely associated with MPS for high WMH (0.077 [0.010, 0.599], .014) but not low WMH participants (1.245 [0.128, 12.132], .850).ConclusionsMPS appear related to lower executive network FC, robust to adjustment for other risk factors, and stronger for those with higher burden of WMH. Future longitudinal studies should examine the interplay between cerebral small vessel disease and connectivity influencing MPS.
dc.publisherWiley Periodicals, Inc.
dc.subject.othermild Parkinsonian signs
dc.subject.otherfunctional connectivity
dc.subject.othercortico‐striatal network
dc.subject.otherwhite matter hyperintensities
dc.titleCortico‐striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172077/1/jon12949_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172077/2/jon12949.pdf
dc.identifier.doi10.1111/jon.12949
dc.identifier.sourceJournal of Neuroimaging
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dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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