Outcomes after definitive surgery for mandibular osteoradionecrosis
dc.contributor.author | Contrera, Kevin J. | |
dc.contributor.author | Chinn, Steven B. | |
dc.contributor.author | Weber, Randal S. | |
dc.contributor.author | Roberts, Dianna | |
dc.contributor.author | Myers, Jeffery N. | |
dc.contributor.author | Lai, Stephen Y. | |
dc.contributor.author | Lewis, Carol M. | |
dc.contributor.author | Hessel, Amy C. | |
dc.contributor.author | Gillenwater, Ann M. | |
dc.contributor.author | Mulcahy, Collin F. | |
dc.contributor.author | Yu, Peirong | |
dc.contributor.author | Hanasono, Matthew M. | |
dc.contributor.author | Fuller, Clifton D. | |
dc.contributor.author | Chambers, Mark S. | |
dc.contributor.author | Zafereo, Mark E. | |
dc.date.accessioned | 2022-05-06T17:25:47Z | |
dc.date.available | 2023-07-06 13:25:45 | en |
dc.date.available | 2022-05-06T17:25:47Z | |
dc.date.issued | 2022-06 | |
dc.identifier.citation | Contrera, Kevin J.; Chinn, Steven B.; Weber, Randal S.; Roberts, Dianna; Myers, Jeffery N.; Lai, Stephen Y.; Lewis, Carol M.; Hessel, Amy C.; Gillenwater, Ann M.; Mulcahy, Collin F.; Yu, Peirong; Hanasono, Matthew M.; Fuller, Clifton D.; Chambers, Mark S.; Zafereo, Mark E. (2022). "Outcomes after definitive surgery for mandibular osteoradionecrosis." Head & Neck 44(6): 1313-1323. | |
dc.identifier.issn | 1043-3074 | |
dc.identifier.issn | 1097-0347 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/172253 | |
dc.description.abstract | ObjectivesTo analyze charges, complications, survival, and functional outcomes for definitive surgery of mandibular osteoradionecrosis (ORN).Materials and MethodsRetrospective analysis of 76 patients who underwent segmental mandibulectomy with reconstruction from 2000 to 2009.ResultsComplications occurred in 49 (65%) patients and were associated with preoperative drainage (odds ratio [OR] 4.40, 95% confidence interval [CI] 1.01–19.27). The adjusted median charge was $343 000, and higher charges were associated with double flap reconstruction (OR 8.15, 95% CI 2.19–30.29) and smoking (OR 5.91, 95% CI 1.69–20.72). Improved swallow was associated with age <67 years (OR 3.76, 95% CI 1.16–12.17) and preoperative swallow (OR 3.42, 95% CI 1.23–9.51). Five-year ORN-recurrence-free survival was 93% while overall survival was 63% and associated with pulmonary disease (HR [hazard ratio] 3.57, 95% CI 1.43–8.94).ConclusionsAlthough recurrence of ORN is rare, surgical complications are common and charges are high. Poorer outcomes and higher charges are associated with preoperative factors. | |
dc.publisher | John Wiley & Sons, Inc. | |
dc.subject.other | outcomes | |
dc.subject.other | survival | |
dc.subject.other | mandibular | |
dc.subject.other | osteoradionecrosis | |
dc.subject.other | hospital charges | |
dc.title | Outcomes after definitive surgery for mandibular osteoradionecrosis | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Otolaryngology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/172253/1/hed27024_am.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/172253/2/hed27024.pdf | |
dc.identifier.doi | 10.1002/hed.27024 | |
dc.identifier.source | Head & Neck | |
dc.identifier.citedreference | Mayland E, Curry JM, Wax MK, et al. Impact of preoperative and intraoperative management on outcomes in osteoradionecrosis requiring free flap reconstruction. Head Neck. 2021; 44 ( 3 ): 698 - 709. | |
dc.identifier.citedreference | Caparrotti F, Huang SH, Lu L, et al. Osteoradionecrosis of the mandible in patients with oropharyngeal carcinoma treated with intensity-modulated radiotherapy. Cancer. 2017; 123 ( 19 ): 3691 - 3700. | |
dc.identifier.citedreference | Tsai CJ, Hofstede TM, Sturgis EM, et al. Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2013; 85 ( 2 ): 415 - 420. | |
dc.identifier.citedreference | Wang X, Hu C, Eisbruch A. Organ-sparing radiation therapy for head and neck cancer. Nat Rev Clin Oncol. 2011; 8 ( 11 ): 639 - 648. | |
dc.identifier.citedreference | Chen JA, Wang CC, Wong YK, et al. Osteoradionecrosis of mandible bone in patients with oral cancer-associated factors and treatment outcomes. Head Neck. 2016; 38 ( 5 ): 762 - 768. | |
dc.identifier.citedreference | Treister NS, Brennan MT, Sollecito TP, et al. Exposed bone in patients with head and neck cancer treated with radiation therapy: an analysis of the observational study of dental outcomes in head and neck cancer patients (OraRad). Cancer. 2021; 128 ( 3 ): 487 - 496. | |
dc.identifier.citedreference | Mendenhall WM. Mandibular osteoradionecrosis. J Clin Oncol. 2004; 22 ( 24 ): 4867 - 4868. | |
dc.identifier.citedreference | Aarup-Kristensen S, Hansen CR, Forner L, Brink C, Eriksen JG, Johansen J. Osteoradionecrosis of the mandible after radiotherapy for head and neck cancer: risk factors and dose-volume correlations. Acta Oncol. 2019; 58 ( 10 ): 1373 - 1377. | |
dc.identifier.citedreference | Nolen D, Cannady SB, Wax MK, et al. Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy. Head Neck. 2014; 36 ( 12 ): 1701 - 1704. | |
dc.identifier.citedreference | Meleca JB, Kerr RP, Prendes BL, Fritz MA. Anterolateral thigh fascia lata rescue flap: a new weapon in the battle against osteoradionecrosis. Laryngoscope. 2021; 131 ( 12 ): 2688 – 2693. | |
dc.identifier.citedreference | Notani K, Yamazaki Y, Kitada H, et al. Management of mandibular osteoradionecrosis corresponding to the severity of osteoradionecrosis and the method of radiotherapy. Head Neck. 2003; 25 ( 3 ): 181 - 186. | |
dc.identifier.citedreference | Bowe C, Butler D, Dhanda J, Gulati A, Norris P, Bisase B. Lateral segmental mandibulectomy reconstruction with bridging reconstruction plate and anterolateral thigh free flap: a case series of 30 consecutive patients. Br J Oral Maxillofac Surg. 2021; 59 ( 1 ): 91 - 96. | |
dc.identifier.citedreference | Haroun K, Coblens OM. Reconstruction of the mandible for osteoradionecrosis. Curr Opin Otolaryngol Head Neck Surg. 2019; 27 ( 5 ): 401 - 406. | |
dc.identifier.citedreference | O’Connell JE, Brown JS, Rogers SN, Bekiroglu F, Schache A, Shaw RJ. Outcomes of microvascular composite reconstruction for mandibular osteoradionecrosis. Br J Oral Maxillofac Surg. 2020; 59 ( 9 ): 1031 - 1035. | |
dc.identifier.citedreference | Lee M, Chin RY, Eslick GD, Sritharan N, Paramaesvaran S. Outcomes of microvascular free flap reconstruction for mandibular osteoradionecrosis: a systematic review. J Craniomaxillofac Surg. 2015; 43 ( 10 ): 2026 - 2033. | |
dc.identifier.citedreference | Chandarana SP, Chanowski EJ, Casper KA, et al. Osteocutaneous free tissue transplantation for mandibular osteoradionecrosis. J Reconstr Microsurg. 2013; 29 ( 1 ): 5 - 14. | |
dc.identifier.citedreference | Statistics USBOL. Consumer price index inflation calculator. U.S. BUREAU OF LABOR STATISTICS. Accessed January 29, 2022. https://www.bls.gov/data/inflation_calculator.htm. 2022. | |
dc.identifier.citedreference | Cannady SB, Dean N, Kroeker A, Albert TA, Rosenthal EL, Wax MK. Free flap reconstruction for osteoradionecrosis of the jaws – outcomes and predictive factors for success. Head Neck. 2011; 33 ( 3 ): 424 - 428. | |
dc.identifier.citedreference | le Nobel GJ, Higgins KM, Enepekides DJ. Predictors of complications of free flap reconstruction in head and neck surgery: analysis of 304 free flap reconstruction procedures. Laryngoscope. 2012; 122 ( 5 ): 1014 - 1019. | |
dc.identifier.citedreference | Chang EI, Zhang H, Liu J, Yu P, Skoracki RJ, Hanasono MM. Analysis of risk factors for flap loss and salvage in free flap head and neck reconstruction. Head Neck. 2015; 38 ( 1 ): 771 - 775. | |
dc.identifier.citedreference | Bettoni J, Olivetto M, Duisit J, et al. The value of reconstructive surgery in the management of refractory jaw osteoradionecrosis: a single-center 10-year experience. Int J Oral Maxillofac Surg. 2019; 48 ( 11 ): 1398 - 1404. | |
dc.identifier.citedreference | Chinn SB, Yao A S., Garvey. Preemptive mandibulectomy and free fibula flap reconstruction for osteoradionecrosis is not superior to delayed reconstruction following orocutaneous fistula or pathologic fracture American Society of Reconstructive Microsurgery Annual Meeting 2016. 2016. | |
dc.identifier.citedreference | Zafereo ME, Hanasono MM, Rosenthal DI, et al. The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx. Cancer. 2009; 115 ( 24 ): 5723 - 5733. | |
dc.identifier.citedreference | Hanasono MM, Zevallos JP, Skoracki RJ, Yu P. A prospective analysis of bony versus soft-tissue reconstruction for posterior mandibular defects. Plast Reconstr Surg. 2010; 125 ( 5 ): 1413 - 1421. | |
dc.identifier.citedreference | Fingeret MC, Hutcheson KA, Jensen K, Yuan Y, Urbauer D, Lewin JS. Associations among speech, eating, and body image concerns for surgical patients with head and neck cancer. Head Neck. 2013; 35 ( 3 ): 354 - 360. | |
dc.identifier.citedreference | Osthus AA, Aarstad AK, Olofsson J, Aarstad HJ. Health-related quality of life scores in long-term head and neck cancer survivors predict subsequent survival: a prospective cohort study. Clin Otolaryngol. 2011; 36 ( 4 ): 361 - 368. | |
dc.identifier.citedreference | Sweeny L, Mayland E, Swendseid BP, et al. Microvascular reconstruction of osteonecrosis: assessment of long-term quality of life. Otolaryngol Head Neck Surg. 2021; 165 ( 5 ): 636 - 646. | |
dc.identifier.citedreference | Hanasono MM, Friel MT, Klem C, et al. Impact of reconstructive microsurgery in patients with advanced oral cavity cancers. Head Neck. 2009; 31 ( 10 ): 1289 - 1296. | |
dc.identifier.citedreference | Fujioka M, Masuda K, Imamura Y. Fatty tissue atrophy of free flap used for head and neck reconstruction. Microsurgery. 2011; 31 ( 1 ): 32 - 35. | |
dc.identifier.citedreference | Yamaguchi K, Kimata Y, Onoda S, Mizukawa N, Onoda T. Quantitative analysis of free flap volume changes in head and neck reconstruction. Head Neck. 2012; 34 ( 10 ): 1403 - 1407. | |
dc.identifier.citedreference | Chinn SB, Myers JN. Oral cavity carcinoma: current management, controversies, and future directions. J Clin Oncol. 2015; 10 ( 33 ): 3269 - 3276. | |
dc.identifier.citedreference | Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983; 41 ( 5 ): 283 - 288. | |
dc.identifier.citedreference | Haffey T, Winters R, Kerr R, Fritz M. Mandibular rescue: application of the ALT fascia free flap to arrest osteoradionecrosis of the mandible. Am J Otolaryngol. 2019; 40 ( 6 ): 102262. | |
dc.identifier.citedreference | Fritz GW, Gunsolley JC, Abubaker O, Laskin DM. Efficacy of pre- and postirradiation hyperbaric oxygen therapy in the prevention of postextraction osteoradionecrosis: a systematic review. J Oral Maxillofac Surg. 2010; 68 ( 11 ): 2653 - 2660. | |
dc.identifier.citedreference | Gigliotti J, Ying Y, Redden D, Kase M, Morlandt AB. Fasciocutaneous flaps for refractory intermediate stage osteoradionecrosis of the mandible-is it time for a shift in management? J Oral Maxillofac Surg. 2021; 79 ( 5 ): 1156 - 1167. | |
dc.identifier.citedreference | Shah JP, Karnell LH, Hoffman HT, et al. Patterns of care for cancer of the larynx in the United States. Arch Otolaryngol Head Neck Surg. 1997; 123 ( 5 ): 475 - 483. | |
dc.identifier.citedreference | Garden AS, Harris J, Trotti A, et al. Long-term results of concomitant boost radiation plus concurrent cisplatin for advanced head and neck carcinomas: a phase II trial of the radiation therapy oncology group (RTOG 99-14). Int J Radiat Oncol Biol Phys. 2008; 71 ( 5 ): 1351 - 1355. | |
dc.identifier.citedreference | Ben-David MA, Diamante M, Radawski JD, et al. Lack of osteoradionecrosis of the mandible after intensity-modulated radiotherapy for head and neck cancer: likely contributions of both dental care and improved dose distributions. Int J Radiat Oncol Biol Phys. 2007; 68 ( 2 ): 396 - 402. | |
dc.identifier.citedreference | Chinn SB, Spector ME, Bellile EL, et al. Impact of perineural invasion in the pathologically N0 neck in oral cavity squamous cell carcinoma. Otolaryngol Head Neck Surg. 2013; 149 ( 6 ): 893 - 899. | |
dc.identifier.citedreference | Ang KK, Trotti A, Brown BW, et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001; 51 ( 3 ): 571 - 578. | |
dc.identifier.citedreference | Rogers SN, D’Souza JJ, Lowe D, Kanatas A. Longitudinal evaluation of health-related quality of life after osteoradionecrosis of the mandible. Br J Oral Maxillofac Surg. 2015; 53 ( 9 ): 854 - 857. | |
dc.working.doi | NO | en |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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