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Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review
dc.contributor.authorReis-Prado, Alexandre H.
dc.contributor.authorAbreu, Lucas G.
dc.contributor.authorFagundes, Rogéria R.
dc.contributor.authorOliveira, Sabrina de C.
dc.contributor.authorBottino, Marco C.
dc.contributor.authorRibeiro-Sobrinho, Antônio P.
dc.contributor.authorBenetti, Francine
dc.date.accessioned2022-05-06T17:25:57Z
dc.date.available2023-07-06 13:25:56en
dc.date.available2022-05-06T17:25:57Z
dc.date.issued2022-06
dc.identifier.citationReis-Prado, Alexandre H. ; Abreu, Lucas G.; Fagundes, Rogéria R. ; Oliveira, Sabrina de C.; Bottino, Marco C.; Ribeiro-Sobrinho, Antônio P. ; Benetti, Francine (2022). "Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review." International Endodontic Journal (6): 579-612.
dc.identifier.issn0143-2885
dc.identifier.issn1365-2591
dc.identifier.urihttps://hdl.handle.net/2027.42/172256
dc.description.abstractBackgroundThe effects of ethylenediaminetetraacetic acid (EDTA) on regenerative endodontic procedures (REPs) are controversial, because, despite releasing growth factors from dentine, some studies show negative effects on cell behaviour.ObjectivesThe aim of the study was to investigate the influence of the use of EDTA in REP on the growth factors’ release, cell behaviour and tissue regeneration.MethodsA systematic search was conducted (PubMed/Medline, Scopus, Cochrane Library, Web of Science, Embase, OpenGrey and reference lists) up to February 2021. Only in vivo and in vitro studies evaluating the effects of EDTA on the biological factors of dentine, pulp/periapical tissues and cell behaviour were eligible. Studies without a control group or available full text were excluded. The growth factors’ release was the primary outcome. Risk of bias in the in vitro and in vivo studies was performed according to Joanna Briggs Institute’s Checklist and SYRCLE’s RoB tool, respectively.ResultsOf the 1848 articles retrieved, 36 were selected. Amongst these, 32 were in vitro, three animal studies and one with both models. The EDTA concentrations ranged from 3% to 15%, at different times. Regarding growth factors’ release (17 studies), 15 studies found significant transforming growth factor (TGF)-β release after dentine conditioning with EDTA, and most found no influence on vascular endothelial growth factor release. Regarding cell behaviour (26 studies), eight studies showed no influence of EDTA-treated dentine on cell viability, whereas, five, nine and six studies showed higher cell migration, adhesion and differentiation respectively. No influence of EDTA conditioning was observed in animal studies. In vitro studies had a low risk of bias, whereas animal studies had high risk of bias. Meta-analysis was unfeasible.DiscussionThis review found that EDTA increased TGF-β release and improved cell activity. However, well-designed histological analyses using immature teeth models are needed.ConclusionsHigh-quality in vitro evidence suggests that EDTA-treated dentine positively influences TGF-β release, cell migration, attachment and differentiation; further research to evaluate its influence on tissue regeneration is necessary due to low methodological quality of the animal studies.
dc.publisherAmerican Association of Endodontists
dc.publisherWiley Periodicals, Inc.
dc.subject.otherstem cells
dc.subject.othersystematic review
dc.subject.othertissue engineering
dc.subject.otherguided tissue regeneration
dc.subject.othergrowth factor(s)
dc.subject.otherEDTA
dc.titleInfluence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172256/1/iej13728.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172256/2/iej13728_am.pdf
dc.identifier.doi10.1111/iej.13728
dc.identifier.sourceInternational Endodontic Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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