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Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report
dc.contributor.authorCable, Jennifer
dc.contributor.authorWeber-Ban, Eilika
dc.contributor.authorClausen, Tim
dc.contributor.authorWalters, Kylie J.
dc.contributor.authorSharon, Michal
dc.contributor.authorFinley, Daniel J.
dc.contributor.authorGu, Yangnan
dc.contributor.authorHanna, John
dc.contributor.authorFeng, Yue
dc.contributor.authorMartens, Sascha
dc.contributor.authorSimonsen, Anne
dc.contributor.authorHansen, Malene
dc.contributor.authorZhang, Hong
dc.contributor.authorGoodwin, Jonathan M.
dc.contributor.authorReggio, Alessio
dc.contributor.authorChang, Chunmei
dc.contributor.authorGe, Liang
dc.contributor.authorSchulman, Brenda A.
dc.contributor.authorDeshaies, Raymond J.
dc.contributor.authorDikic, Ivan
dc.contributor.authorHarper, J. Wade
dc.contributor.authorWertz, Ingrid E.
dc.contributor.authorThomä, Nicolas H.
dc.contributor.authorSłabicki, Mikołaj
dc.contributor.authorFrydman, Judith
dc.contributor.authorJakob, Ursula
dc.contributor.authorDavid, Della C.
dc.contributor.authorBennett, Eric J.
dc.contributor.authorBertozzi, Carolyn R.
dc.contributor.authorSardana, Richa
dc.contributor.authorEapen, Vinay V.
dc.contributor.authorCarra, Serena
dc.date.accessioned2022-05-06T17:26:35Z
dc.date.available2023-05-06 13:26:34en
dc.date.available2022-05-06T17:26:35Z
dc.date.issued2022-04
dc.identifier.citationCable, Jennifer; Weber-Ban, Eilika ; Clausen, Tim; Walters, Kylie J.; Sharon, Michal; Finley, Daniel J.; Gu, Yangnan; Hanna, John; Feng, Yue; Martens, Sascha; Simonsen, Anne; Hansen, Malene; Zhang, Hong; Goodwin, Jonathan M.; Reggio, Alessio; Chang, Chunmei; Ge, Liang; Schulman, Brenda A.; Deshaies, Raymond J.; Dikic, Ivan; Harper, J. Wade; Wertz, Ingrid E.; Thomä, Nicolas H. ; Słabicki, Mikołaj ; Frydman, Judith; Jakob, Ursula; David, Della C.; Bennett, Eric J.; Bertozzi, Carolyn R.; Sardana, Richa; Eapen, Vinay V.; Carra, Serena (2022). "Targeted protein degradation: from small molecules to complex organelles- a Keystone Symposia report." Annals of the New York Academy of Sciences 1510(1): 79-99.
dc.identifier.issn0077-8923
dc.identifier.issn1749-6632
dc.identifier.urihttps://hdl.handle.net/2027.42/172273
dc.description.abstractTargeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome–lysosome pathway, must be tightly regulated to ensure proper elimination of misfolded and aggregated proteins and regulate changing protein levels during cellular differentiation, while ensuring that normal proteins remain unscathed. Protein degradation pathways have also garnered interest as a means to selectively eliminate target proteins that may be difficult to inhibit via other mechanisms. On June 7 and 8, 2021, several experts in protein degradation pathways met virtually for the Keystone eSymposium “Targeting protein degradation: from small molecules to complex organelles.” The event brought together researchers working in different protein degradation pathways in an effort to begin to develop a holistic, integrated vision of protein degradation that incorporates all the major pathways to understand how changes in them can lead to disease pathology and, alternatively, how they can be leveraged for novel therapeutics.Protein quality control is critical to maintain proper cellular function and development. Accumulation and subsequent aggregation of misfolded proteins is a hallmark of several diseases. Cells have devised several mechanisms to identify misfolded proteins and understanding these protein clearance pathways is key to not only understanding how their dysfunction is involved in disease pathology but also to harnessing these systems for therapeutic applications. On Demand: https://keysym.us/21EK40NYAS
dc.publisherWiley Periodicals, Inc.
dc.subject.otherprotein degradation
dc.subject.otheraggregation
dc.subject.otherautophagy
dc.subject.otherlysophagy
dc.subject.otherproteasome
dc.subject.otherubiquitin
dc.titleTargeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelScience (General)
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172273/1/nyas14745.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172273/2/nyas14745_am.pdf
dc.identifier.doi10.1111/nyas.14745
dc.identifier.sourceAnnals of the New York Academy of Sciences
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