View Item 

Show simple item record

Change in posttraumatic stress disorder–related thoughts during treatment: Do thoughts drive change when pills are involved?
dc.contributor.authorRauch, Sheila A.M.
dc.contributor.authorKim, H. Myra
dc.contributor.authorVenners, Margaret R.
dc.contributor.authorPorter, Katherine E.
dc.contributor.authorNorman, Sonya B.
dc.contributor.authorSimon, Naomi M.
dc.contributor.authorRothbaum, Barbara O.
dc.contributor.authorTuerk, Peter W.
dc.contributor.authorAcierno, Ronald E.
dc.contributor.authorBui, Eric
dc.contributor.authorPowell, Corey
dc.contributor.authorSmith, Erin R.
dc.contributor.authorGoetter, Elizabeth
dc.contributor.authorMcSweeney, Lauren B.
dc.date.accessioned2022-05-06T17:28:13Z
dc.date.available2023-05-06 13:28:12en
dc.date.available2022-05-06T17:28:13Z
dc.date.issued2022-04
dc.identifier.citationRauch, Sheila A.M.; Kim, H. Myra; Venners, Margaret R.; Porter, Katherine E.; Norman, Sonya B.; Simon, Naomi M.; Rothbaum, Barbara O.; Tuerk, Peter W.; Acierno, Ronald E.; Bui, Eric; Powell, Corey; Smith, Erin R.; Goetter, Elizabeth; McSweeney, Lauren B. (2022). "Change in posttraumatic stress disorder–related thoughts during treatment: Do thoughts drive change when pills are involved?." Journal of Traumatic Stress 35(2): 496-507.
dc.identifier.issn0894-9867
dc.identifier.issn1573-6598
dc.identifier.urihttps://hdl.handle.net/2027.42/172308
dc.description.abstractPosttraumatic negative thoughts about one’s self and the world are related to posttraumatic stress disorder (PTSD) symptom severity and change in cognitive behavioral treatment (CBT), but little is known about this association when CBT is delivered with medication. The current study presents a planned comparison of changes in negative posttraumatic thoughts during (a) prolonged exposure (PE) plus pill placebo (PE+PLB), (b) sertraline plus enhanced medication management (SERT+EMM), and (c) PE plus sertraline (PE+SERT) as part of a randomized clinical trial in a sample of 176 veterans. Lagged regression modeling revealed that change in posttraumatic negative thoughts was associated with PTSD symptom change in the conditions in which participants received sertraline, ds = 0.14–0.25, ps = 0.04–.001). However, contrary to previous research, the models that started with symptom change were also statistically significant, d = 0.23, p < .001, for the lagged effect of symptoms on negative thoughts about self in the SERT+EMM condition, indicating a bidirectional association between such thoughts and PTSD symptoms. In the PE+PLB condition, no significant association between posttraumatic thoughts and PTSD symptoms emerged in either direction. These results suggest that the previously demonstrated role of change in posttraumatic thoughts leading to PTSD symptom reduction in PE may be altered when combined with pill administration, either active or placebo.
dc.publisherWiley Periodicals, Inc.
dc.publisherOxford University Press
dc.titleChange in posttraumatic stress disorder–related thoughts during treatment: Do thoughts drive change when pills are involved?
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172308/1/jts22762_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172308/2/jts22762.pdf
dc.identifier.doi10.1002/jts.22762
dc.identifier.sourceJournal of Traumatic Stress
dc.identifier.citedreferenceRauch, S. A. M., Kim, H. M., Powell, C., Tuerk, P. W., Simon, N. M., Acierno, R., Allard, C. B., Norman, S. B., Venners, M. R., Rothbaum, B. O., Stein, M. B., Porter, K., Martis, B., King, A. P., Liberzon, I., Phan, K. L., & Hoge, C. W. ( 2019 ). Efficacy of prolonged exposure therapy, sertraline hydrochloride, and their combination among combat veterans with posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry, 76 ( 2 ), 117 – 126. https://doi.org/10.1001/jamapsychiatry.2018.3412
dc.identifier.citedreferenceBiondi, M., & Picardi, A. ( 2003 ). Attribution of improvement to medication and increased risk of relapse of panic disorder with agoraphobia. Psychotherapy and Psychosomatics, 72 ( 2 ), 110 – 111. https://doi.org/10.1159/000068687
dc.identifier.citedreferenceBlake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. ( 1995 ). The development of a clinician-administered PTSD scale. Journal of Traumatic Stress, 8 ( 1 ), 75 – 90. https://doi.org/10.1007/BF02105408
dc.identifier.citedreferenceCohen, J. N., Potter, C. M., Drabick, D. A. G., Blanco, C., Schneier, F. R., Liebowitz, M. R., & Heimberg, R. G. ( 2015 ). Clinical presentation and pharmacotherapy response in social anxiety disorder: The effect of etiological beliefs. Psychiatry Research, 228 ( 1 ), 65 – 71. https://doi.org/10.1016/j.psychres.2015.04.014
dc.identifier.citedreferenceCooper, A. A., Zoellner, L. A., Roy-Byrne, P., Mavissakalian, M. R., & Feeny, N. C. ( 2017 ). Do changes in trauma-related beliefs predict PTSD symptom improvement in prolonged exposure and sertraline? Journal of Consulting and Clinical Psychology, 85 ( 9 ), 873 – 882. https://doi.org/10.1037/ccp0000220
dc.identifier.citedreferenceCraske, M. G., Treanor, M., Conway, C. C., Zbozinek, T., & Vervliet, B. ( 2014 ). Maximizing exposure therapy: An inhibitory learning approach. Behaviour Research and Therapy, 58, 10 – 23. https://doi.org/10.1016/j.brat.2014.04.006
dc.identifier.citedreferenceDuval, E. R., Sheynin, J., King, A. P., Phan, K. L., Simon, N. M., Martis, B., Porter, K. E., Norman, S. B., Liberzon, I., & Rauch, S. A. M. ( 2020 ). Neural function during emotion processing and modulation associated with treatment response in a randomized clinical trial for posttraumatic stress disorder. Depression and Anxiety, 37 ( 7 ), 670 – 681. https://doi.org/10.1002/da.23022
dc.identifier.citedreferenceFoa, E. B., Ehlers, A., Clark, D. M., Tolin, D. F., & Orsillo, S. M. ( 1999 ). The Posttraumatic Cognitions Inventory (PTCI): Development and validation. Psychological Assessment, 11 ( 3 ), 303 – 314. https://doi.org/10.1037/1040-3590.11.3.303
dc.identifier.citedreferenceFoa, E. B., Hembree, E. A., & Rothbaum, B. O. ( 2007 ). Prolonged exposure therapy for PTSD: Therapist guide. Oxford University Press.
dc.identifier.citedreferenceFoa, E. B., & Rauch, S. A. ( 2004 ). Cognitive changes during prolonged exposure versus prolonged exposure plus cognitive restructuring in female assault survivors with posttraumatic stress disorder. Journal of Consulting and Clinical Psychology, 72 ( 5 ), 879 – 884. https://doi.org/10.1037/0022-006x.72.5.879
dc.identifier.citedreferenceFoa, E., Hembree, E. c., Cahill, S., Rauch, S., Riggs, D., Feeny, N., & Yadin, E. ( 2005 ). Randomized trial of prolonged exposure for PTSD with and without cognitive restructuring: Outcome at academic and community clinics. Journal of Consulting and Clinical Psychology, 73 ( 5 ), 953 – 964. https://doi.org/10.1037/0022-006X.73.5.953
dc.identifier.citedreferenceGranger, C. W. J. ( 1969 ). Investigating causal relations by econometric models and cross-spectral methods. Econometrica: Journal of the Econometric Society, 37, 424 – 438. https://doi.org/10.2307/1912791
dc.identifier.citedreferenceJoshi, S. A., Duval, E. R., Sheynin, J., King, A. P., Phan, K. L., Martis, B., Porter, K. E., Liberzon, I., & Rauch, S. A. M. ( 2020 ). Neural correlates of emotional reactivity and regulation associated with treatment response in a randomized clinical trial for posttraumatic stress disorder. Psychiatry Research: Neuroimaging, 299, 111062. https://doi.org/10.1016/j.pscychresns.2020.111062
dc.identifier.citedreferenceKline, A. C., Cooper, A. A., Rytwinksi, N. K., & Feeny, N. C. ( 2018 ). Long-term efficacy of psychotherapy for posttraumatic stress disorder: A meta-analysis of randomized controlled trials. Clinical Psychology Review, 59, 30 – 40. https://doi.org/10.1016/j.cpr.2017.10.009
dc.identifier.citedreferenceKumpula, M. J., Pentel, K. Z., Foa, E. B., LeBlanc, N. J., Bui, E., McSweeney, L. B., Knowles, K., Bosley, H., Simon, N. M., & Rauch, S. A. ( 2017 ). Temporal sequencing of change in posttraumatic cognitions and PTSD symptom reduction during prolonged exposure therapy. Behavior Therapy, 48 ( 2 ), 156 – 165. https://doi.org/10.1016/j.beth.2016.02.008
dc.identifier.citedreferenceMcGrath, C. L., Kelley, M. E., Holtzheimer, P. E., Dunlop, B. W., Craighead, W. E., Franco, A. R., Craddock, R. C., & Mayberg, H. S. ( 2013 ). Toward a neuroimaging treatment selection biomarker for major depressive disorder. JAMA Psychiatry, 70 ( 8 ), 821 – 829. https://doi.org/10.1001/jamapsychiatry.2013.143
dc.identifier.citedreferenceRauch, S. A. M., King, A., Kim, H. M., Powell, C., Rajaram, N., Venners, M., Simon, N. M., Hamner, M., & Liberzon, I. ( 2020 ). Cortisol awakening response in PTSD treatment: Predictor or mechanism of change. Psychoneuroendocrinology, 118, 104714. https://doi.org/10.1016/j.psyneuen.2020.104714
dc.identifier.citedreferenceRauch, S. A., Abelson, J., Javanbahkt, A., & Liberzon, I. ( 2015 ). Neurobiology and translational approaches to posttraumatic stress disorder. In ( K. J. Ressler, D. S. Pine, & B. O. Rothbaum Eds.), anxiety disorders: Translational perspectives on diagnosis and treatment. Oxford University Press.
dc.identifier.citedreferenceRauch, S. A., King, A. P., Abelson, J., Tuerk, P. W., Smith, E., Rothbaum, B. O., Clifton, E., Defever, A., & Liberzon, I. ( 2015 ). Biological and symptom changes in posttraumatic stress disorder treatment: A randomized clinical trial. Depression and Anxiety, 32 ( 3 ), 204 – 212. https://doi.org/10.1002/da.22331
dc.identifier.citedreferenceRauch, S. A., Simon, N. M., Kim, H. M., Acierno, R., King, A. P., Norman, S. B., Venners, M. R., Porter, K., Phan, K. L., & Tuerk, P. W. ( 2018 ). Integrating biological treatment mechanisms into randomized clinical trials: Design of PROGrESS (PROlonGed ExpoSure and Sertraline Trial). Contemporary Clinical Trials, 64, 128 – 138. https://doi.org/10.1016/j.cct.2017.10.013
dc.identifier.citedreferenceRauch, S., & Foa, E. ( 2006 ). Emotional processing theory (EPT) and exposure therapy for PTSD. Journal of Contemporary Psychotherapy, 36 ( 2 ), 61 – 65. https://doi.org/10.1007/s10879-006-9008-y
dc.identifier.citedreferenceRothbaum, B. O., Cahill, S. P., Foa, E. B., Davidson, J. R., Compton, J., Connor, K. M., Astin, M. C., & Hahn, C. G. ( 2006 ). Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder. Journal of Traumatic Stress, 19 ( 5 ), 625 – 638. https://doi.org/10.1002/jts.20170
dc.identifier.citedreferenceSchaumberg, K., Kuerbis, A., Morgenstern, J., & Muench, F. ( 2013 ). Attributions of change and self-efficacy in a randomized controlled trial of medication and psychotherapy for problem drinking. Behavior Therapy, 44 ( 1 ), 88 – 99. https://doi.org/10.1016/j.beth.2012.07.001
dc.identifier.citedreferenceSimon, N. M., Connor, K. M., Lang, A. J., Rauch, S., Krulewicz, S., LeBeau, R. T., Davidson, J. R., Stein, M. B., Otto, M. W., Foa, E. B., & Pollack, M. H. ( 2008 ). Paroxetine CR augmentation for posttraumatic stress disorder refractory to prolonged exposure therapy. Journal of Clinical Psychiatry, 69 ( 3 ), 400 – 405. https://doi.org/10.4088/jcp.v69n0309
dc.identifier.citedreferenceSripada, R. K., Ready, D. J., Ganoczy, D., Astin, M. C., & Rauch, S. A. M. ( 2019 ). When to change the treatment plan: An analysis of diminishing returns in VA patients undergoing prolonged exposure and cognitive processing therapy. Behavior Therapy, 51 ( 1 ), 85 – 98. https://doi.org/10.1016/j.beth.2019.05.003
dc.identifier.citedreferenceZalta, A. K., Gillihan, S. J., Fisher, A. J., Mintz, J., McLean, C. P., Yehuda, R., & Foa, E. B. ( 2014 ). Change in negative cognitions associated with PTSD predicts symptom reduction in prolonged exposure. Journal of Consulting and Clinical Psychology, 82 ( 1 ), 171 – 175. https://doi.org/10.1037/a0034735
dc.identifier.citedreferenceZilcha-Mano, S., Chui, H., Dolev, T., McCarthy, K. S., Dinger, U., & Barber, J. P. ( 2016 ). Changes in causal attributions and relationship representations: Are they specific or common mechanisms in the treatment of depression? Journal of Affective Disorders, 193, 73 – 80. https://doi.org/10.1016/j.jad.2015.12.073
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
jts22762_am.pdf
Size:
681.9KB
Format:
PDF
View/Open
Name:
jts22762.pdf
Size:
251.2KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.