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A Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing
dc.contributor.authorLiu, Jing
dc.contributor.authorQu, Moyuan
dc.contributor.authorWang, Canran
dc.contributor.authorXue, Yumeng
dc.contributor.authorHuang, Hui
dc.contributor.authorChen, Qianming
dc.contributor.authorSun, Wujin
dc.contributor.authorZhou, Xingwu
dc.contributor.authorXu, Guihua
dc.contributor.authorJiang, Xing
dc.date.accessioned2022-05-06T17:30:14Z
dc.date.available2023-05-06 13:30:11en
dc.date.available2022-05-06T17:30:14Z
dc.date.issued2022-04
dc.identifier.citationLiu, Jing; Qu, Moyuan; Wang, Canran; Xue, Yumeng; Huang, Hui; Chen, Qianming; Sun, Wujin; Zhou, Xingwu; Xu, Guihua; Jiang, Xing (2022). "A Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing." Small 18(17): n/a-n/a.
dc.identifier.issn1613-6810
dc.identifier.issn1613-6829
dc.identifier.urihttps://hdl.handle.net/2027.42/172348
dc.description.abstractDiabetic wound treatment faces significant challenges in clinical settings. Alternative treatment approaches are needed. Continuous bleeding, disordered inflammatory regulation, obstruction of cell proliferation, and disturbance of tissue remodeling are the main characteristics of diabetic wound healing. Hydrogels made of either naturally derived or synthetic materials can potentially be designed with a variety of functions for managing the healing process of chronic wounds. Here, a hemostatic and anti-inflammatory hydrogel patch is designed for promoting diabetic wound healing. The hydrogel patch is derived from dual-cross-linked methacryloyl-substituted Bletilla Striata polysaccharide (B) and gelatin (G) via ultraviolet (UV) light. It is demonstrated that the B–G hydrogel can effectively regulate the M1/M2 phenotype of macrophages, significantly promote the proliferation and migration of fibroblasts in vitro, and accelerate angiogenesis. It can boost wound closure by normalizing epidermal tissue regeneration and depositing collagen appropriately in vivo without exogenous cytokine supplementation. Overall, the B–G bioactive hydrogel can promote diabetic wound healing in a simple, economical, effective, and safe manner.The prominent multifunctional properties of a dual-cross-linked B–G hydrogel patch enable promising applications in treating chronic wound healing by modulating inflammation, accelerating granulation tissue formation, promoting collagen deposition, reinforcing hemostasia, and inducing vascularization.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherdual-cross-linked hydrogels
dc.subject.otherwound healing
dc.subject.otherinflammation modulation
dc.titleA Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMaterials Science and Engineering
dc.subject.hlbsecondlevelPhysics
dc.subject.hlbtoplevelScience
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172348/1/smll202106172-sup-0001-SuppMat.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172348/2/smll202106172.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172348/3/smll202106172_am.pdf
dc.identifier.doi10.1002/smll.202106172
dc.identifier.sourceSmall
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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