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A (dis)integrated stress response: Genetic diseases of eIF2α regulators
dc.contributor.authorEnglish, Alyssa M.
dc.contributor.authorGreen, Katelyn M.
dc.contributor.authorMoon, Stephanie L.
dc.date.accessioned2022-06-01T20:29:04Z
dc.date.available2023-06-01 16:29:02en
dc.date.available2022-06-01T20:29:04Z
dc.date.issued2022-05
dc.identifier.citationEnglish, Alyssa M.; Green, Katelyn M.; Moon, Stephanie L. (2022). "A (dis)integrated stress response: Genetic diseases of eIF2α regulators." Wiley Interdisciplinary Reviews: RNA 13(3): n/a-n/a.
dc.identifier.issn1757-7004
dc.identifier.issn1757-7012
dc.identifier.urihttps://hdl.handle.net/2027.42/172812
dc.description.abstractThe integrated stress response (ISR) is a conserved mechanism by which eukaryotic cells remodel gene expression to adapt to intrinsic and extrinsic stressors rapidly and reversibly. The ISR is initiated when stress-activated protein kinases phosphorylate the major translation initiation factor eukaryotic translation initiation factor 2ɑ (eIF2ɑ), which globally suppresses translation initiation activity and permits the selective translation of stress-induced genes including important transcription factors such as activating transcription factor 4 (ATF4). Translationally repressed messenger RNAs (mRNAs) and noncoding RNAs assemble into cytoplasmic RNA–protein granules and polyadenylated RNAs are concomitantly stabilized. Thus, regulated changes in mRNA translation, stability, and localization to RNA–protein granules contribute to the reprogramming of gene expression that defines the ISR. We discuss fundamental mechanisms of RNA regulation during the ISR and provide an overview of a growing class of genetic disorders associated with mutant alleles of key translation factors in the ISR pathway.This article is categorized under:RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional ImplicationsRNA in Disease and Development > RNA in DiseaseTranslation > Translation RegulationRNA in Disease and Development > RNA in DevelopmentMessenger RNA (mRNA) translation and decay are rapidly suppressed as RNA–protein granules form during the integrated stress response (ISR) to drive cell adaptation to stress conditions. Genetic diseases caused by mutant alleles of key ISR genes suggest an important role for the ISR in human development and health.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.othergenetic diseases
dc.subject.otherRNA–protein granules
dc.subject.othertranslation
dc.subject.otherintegrated stress response
dc.subject.othereIF2α
dc.titleA (dis)integrated stress response: Genetic diseases of eIF2α regulators
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelGenetics
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172812/1/wrna1689.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172812/2/wrna1689_am.pdf
dc.identifier.doi10.1002/wrna.1689
dc.identifier.sourceWiley Interdisciplinary Reviews: RNA
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