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Relationship between periodontitis and psoriasis: A two-sample Mendelian randomization study
dc.contributor.authorBaurecht, Hansjörg
dc.contributor.authorFreuer, Dennis
dc.contributor.authorWelker, Christine
dc.contributor.authorTsoi, Lam C.
dc.contributor.authorElder, James T.
dc.contributor.authorEhmke, Benjamin
dc.contributor.authorLeitzmann, Michael F.
dc.contributor.authorHoltfreter, Birte
dc.contributor.authorBaumeister, Sebastian-Edgar
dc.date.accessioned2022-06-01T20:29:42Z
dc.date.available2023-07-01 16:29:40en
dc.date.available2022-06-01T20:29:42Z
dc.date.issued2022-06
dc.identifier.citationBaurecht, Hansjörg ; Freuer, Dennis; Welker, Christine; Tsoi, Lam C.; Elder, James T.; Ehmke, Benjamin; Leitzmann, Michael F.; Holtfreter, Birte; Baumeister, Sebastian-Edgar (2022). "Relationship between periodontitis and psoriasis: A two- sample Mendelian randomization study." Journal of Clinical Periodontology 49(6): 573-579.
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.urihttps://hdl.handle.net/2027.42/172825
dc.description.abstractAimObservational research suggests that periodontitis affects psoriasis. However, observational studies are prone to reverse causation and confounding, which hampers drawing causal conclusions and the effect direction. We applied the Mendelian randomization (MR) method to comprehensively assess the potential bi-directional association between periodontitis and psoriasis.Materials and MethodsWe used genetic instruments from the largest available genome-wide association study of European descent for periodontitis (17,353 cases, 28,210 controls) to investigate the relationship with psoriasis (13,229 cases, 21,543 controls), and vice versa. Causal Analysis Using Summary Effect (CAUSE) estimates and inverse variance-weighted (IVW) MR analyses were used for the primary analysis. Robust MR approaches were used for sensitivity analyses.ResultsBoth univariable methods, CAUSE and IVW MR analyses, did not reveal any impact of periodontitis on psoriasis (CAUSE odds ratio [OR] = 1.00, p = 1.00; IVW OR = 1.02, p = .6247), or vice versa (CAUSE OR = 1.01, p = .5135; IVW OR = 1.00, p = .7070). The null association was corroborated by pleiotropy-robust methods with ORs close to 1 and p-values >.59. Overall, MR analyses did not suggest any effect of periodontitis on psoriasis. Similarly, there was no evidence to support an effect of psoriasis on periodontitis.ConclusionsWithin the limitations of this MR study, the outcomes supported neither periodontitis affecting psoriasis nor psoriasis affecting periodontitis.
dc.publisherWiley Periodicals, Inc.
dc.publisherBlackwell Publishing Ltd
dc.subject.otherpsoriasis
dc.subject.otherepidemiology
dc.subject.otherMendelian randomization
dc.subject.otherperiodontitis
dc.titleRelationship between periodontitis and psoriasis: A two-sample Mendelian randomization study
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172825/1/jcpe13620.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172825/2/jcpe13620_am.pdf
dc.identifier.doi10.1111/jcpe.13620
dc.identifier.sourceJournal of Clinical Periodontology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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