Show simple item record

Did prescribing laws disproportionately affect opioid dispensing to Black patients?

dc.contributor.authorTownsend, Tarlise N.
dc.contributor.authorBohnert, Amy S. B.
dc.contributor.authorLagisetty, Pooja
dc.contributor.authorHaffajee, Rebecca L.
dc.date.accessioned2022-06-01T20:29:52Z
dc.date.available2023-07-01 16:29:50en
dc.date.available2022-06-01T20:29:52Z
dc.date.issued2022-06
dc.identifier.citationTownsend, Tarlise N.; Bohnert, Amy S. B.; Lagisetty, Pooja; Haffajee, Rebecca L. (2022). "Did prescribing laws disproportionately affect opioid dispensing to Black patients?." Health Services Research 57(3): 482-496.
dc.identifier.issn0017-9124
dc.identifier.issn1475-6773
dc.identifier.urihttps://hdl.handle.net/2027.42/172828
dc.description.abstractObjectiveTo evaluate whether pain management clinic laws and prescription drug monitoring program (PDMP) prescriber check mandates, two state opioid policies with relatively rapid adoption across states, reduced opioid dispensing more or less in Black versus White patients.Data SourcesPharmacy claims data, US sample of commercially insured adults, 2007–2018.Study DesignStratifying by race, we used generalized estimating equations with an event-study specification to estimate time-varying effects of each policy on opioid dispensing, comparing to the four pre-policy quarters and states without the policy. Outcomes included high-dosage opioids, overlapping opioid prescriptions, concurrent opioid/benzodiazepines, opioids from >3 prescribers, opioids from >3 pharmacies.Data Extraction MethodsWe identified all prescription opioid dispensing to Black and White adults aged 18–64 without a palliative care or cancer diagnosis code.Principal FindingsExactly 7,096,592 White and 1,167,310 Black individuals met inclusion criteria. Pain management clinic laws were associated with reductions in two outcomes; their association with high-dosage receipt was larger among White patients. In contrast, reductions due to PDMP mandates appeared limited to, or larger in, Black patients compared with White patients in four of five outcomes. For example, PDMP mandates reduced high-dosage receipt in Black patients by 0.7 percentage points (95% CI: 0.36–1.08 ppt.) over 4 years: an 8.4% decrease from baseline; there was no apparent effect in White patients. Similarly, while there was limited evidence that mandates reduced overlapping opioid receipt in White patients, they appeared to reduce overlapping opioid receipt in Black patients by 1.3 ppt. (95% CI: −1.66–−1.01 ppt.) across post-policy years—a 14.4% decrease from baseline.ConclusionsPDMP prescriber check mandates but not pain management clinic laws appeared to reduce opioid dispensing more in Black patients than White patients. Future research should discern the mechanisms underlying these disparities and their consequences for pain management.
dc.publisherWiley Periodicals, Inc.
dc.publisherBlackwell Publishing Ltd
dc.subject.otherprescriptions
dc.subject.otherracial discrimination
dc.subject.otherracial disparities
dc.subject.otheropioids
dc.subject.otherpolicy
dc.subject.otherracial inequity
dc.titleDid prescribing laws disproportionately affect opioid dispensing to Black patients?
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172828/1/hesr13968_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172828/2/hesr13968.pdf
dc.identifier.doi10.1111/1475-6773.13968
dc.identifier.sourceHealth Services Research
dc.identifier.citedreferenceGoodman-Bacon A, Marcus J. Using difference-in-differences to identify causal effects of COVID-19 policies. SSRN J. Published online 2020. doi: 10.2139/ssrn.3603970
dc.identifier.citedreferenceCintron A, Morrison RS. Pain and ethnicity in the United States: a systematic review. J Palliat Med. 2006; 9 ( 6 ): 1454 - 1473. doi: 10.1089/jpm.2006.9.1454
dc.identifier.citedreferenceBoulware LE, Cooper LA, Ratner LE, LaVeist TA, Powe NR. Race and trust in the health care system. Public Health Rep. 2003; 118: 358 - 365.
dc.identifier.citedreferenceUniversity of Michigan Institute for Healthcare Policy and Innovation. OptumInsight Data Seminar. Presented at: 2016.
dc.identifier.citedreferenceJeffery MM, Hooten WM, Henk HJ, et al. Trends in opioid use in commercially insured and Medicare Advantage populations in 2007-16: retrospective cohort study. BMJ. Published online August 1, 2018. k2833. doi: 10.1136/bmj.k2833
dc.identifier.citedreferenceRose AJ, Bernson D, Chui KKH, et al. Potentially inappropriate opioid prescribing, overdose, and mortality in Massachusetts, 2011–2015. J Gen Intern Med. 2018; 33 ( 9 ): 1512 - 1519. doi: 10.1007/s11606-018-4532-5
dc.identifier.citedreferenceBerchick ER, Hood E, Barnett JC. Health Insurance Coverage in the United States: 2017. U.S. Census Bureau; 2018:44. Accessed January 10, 2020. https://www.census.gov/content/dam/Census/library/publications/2018/demo/p60-264.pdf
dc.identifier.citedreferenceU.S. Census Bureau. American Community Survey Data. U.S. Census Bureau. Published October 11, 2018. Accessed July 12, 2019. https://www.census.gov/programs-surveys/acs/data.html
dc.identifier.citedreferenceGoodman-Bacon A. Difference-in-Differences with Variation in Treatment Timing. National Bureau of Economic Research; 2018: w25018. doi: 10.3386/w25018
dc.identifier.citedreferenceMarcus M, Sant’Anna PHC. The role of parallel trends in event study settings: an application to environmental economics. J Assoc Environ Resour Econ. 2021; 8 ( 2 ): 235 - 275. doi: 10.1086/711509
dc.identifier.citedreferenceUniversity of Michigan Research Ethics and Compliance. Does my project require IRB review? Accessed February 10, 2020. https://research-compliance.umich.edu/faqs/does-my-project-require-irb-review
dc.identifier.citedreferenceNYU Langone Health. Getting Started with the Institutional Review Board Submission Process. Published online 2020. Accessed November 29, 2020. https://med.nyu.edu/research/office-science-research/clinical-research/resources-researchers-study-teams/institutional-review-board-operations/getting-started-the-irb-submission-process#determine-if-your-project-is-human-subjects-research
dc.identifier.citedreferenceHimmelstein MS, Young DM, Sanchez DT, Jackson JS. Vigilance in the discrimination-stress model for Black Americans. Psychol Health. 2015; 30 ( 3 ): 253 - 267. doi: 10.1080/08870446.2014.966104
dc.identifier.citedreferenceHicken MT, Lee H, Ailshire J, Burgard SA, Williams DR. “Every shut eye, ain’t sleep”: the role of racism-related vigilance in racial/ethnic disparities in sleep difficulty. Race Soc Probl. Published online 2014. 20.
dc.identifier.citedreferenceDelcher C, Harris DR, Park C, Strickler G, Talbert J, Freeman PR. “Doctor and pharmacy shopping”: a fading signal for prescription opioid use monitoring? Drug Alcohol Depend. Published online February 2021. 108618. doi: 10.1016/j.drugalcdep.2021.108618
dc.identifier.citedreferenceMartins SS, Ponicki W, Smith N, et al. Prescription drug monitoring programs operational characteristics and fatal heroin poisoning. Int J Drug Policy. 2019; 74: 174 - 180. doi: 10.1016/j.drugpo.2019.10.001
dc.identifier.citedreferenceAlpert A, Powell D, Pacula RL. Supply-Side Drug Policy in the Presence of Substitutes: Evidence from the Introduction of Abuse-Deterrent Opiods:60.
dc.identifier.citedreferenceEvans WN, Lieber EMJ, Power P. How the reformulation of OxyContin ignited the heroin epidemic. Rev Econ Stat. 2019; 101 ( 1 ): 1 - 15. doi: 10.1162/rest_a_00755
dc.identifier.citedreferenceAli MM, Dowd WN, Classen T, Mutter R, Novak SP. Prescription drug monitoring programs, nonmedical use of prescription drugs, and heroin use: evidence from the National Survey of Drug Use and Health. Addict Behav. 2017; 69: 65 - 77. doi: 10.1016/j.addbeh.2017.01.011
dc.identifier.citedreferenceBeheshti D. Adverse health effects of abuse-deterrent opioids: evidence from the reformulation of OxyContin. Health Econ. 2019; 28 ( 12 ): 1449 - 1461. doi: 10.1002/hec.3944
dc.identifier.citedreferenceJones CM, Campopiano M, Baldwin G, McCance-Katz E. National and state treatment need and capacity for opioid agonist medication-assisted treatment. Am J Public Health. 2015; 105 ( 8 ): e55 - e63. doi: 10.2105/AJPH.2015.302664
dc.identifier.citedreferenceKilaru AS, Xiong A, Lowenstein M, et al. Incidence of treatment for opioid use disorder following nonfatal overdose in commercially insured patients. JAMA Netw Open. 2020; 3 ( 5 ): e205852. doi: 10.1001/jamanetworkopen.2020.5852
dc.identifier.citedreferenceHaffajee RL, Mello MM, Zhang F, Zaslavsky AM, Larochelle MR, Wharam JF. Four states with robust prescription drug monitoring programs reduced opioid dosages. Health Aff. 2018; 37 ( 6 ): 964 - 974. doi: 10.1377/hlthaff.2017.1321
dc.identifier.citedreferenceSmith N, Martins SS, Kim J, et al. A typology of prescription drug monitoring programs: a latent transition analysis of the evolution of programs from 1999 to 2016: PDMP typologies. Addiction. 2019; 114 ( 2 ): 248 - 258. doi: 10.1111/add.14440
dc.identifier.citedreferenceRigg J. Moving lives: migration and livelihoods in the Lao PDR. Popul Space Place. 2007; 13 ( 3 ): 163 - 178. doi: 10.1002/psp.438
dc.identifier.citedreferenceDowell D, Haegerich T, Chou R. No shortcuts to safer opioid prescribing. N Engl J Med. 2019; 380 ( 24 ): 2285 - 2287. doi: 10.1056/NEJMp1904190
dc.identifier.citedreferenceCiccarone D. The triple wave epidemic: supply and demand drivers of the US opioid overdose crisis. Int J Drug Policy. 2019; 71: 183 - 188. doi: 10.1016/j.drugpo.2019.01.010
dc.identifier.citedreferenceDowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. JAMA. 2016; 315 ( 15 ): 1624 - 1645. doi: 10.1001/jama.2016.1464
dc.identifier.citedreferenceMauri AI, Townsend TN, Haffajee RL. The association of state opioid misuse prevention policies with patient- and provider-related outcomes: a scoping review. Milbank Q. 2019; 98 ( 1 ): 57 - 105. doi: 10.1111/1468-0009.12436
dc.identifier.citedreferenceHall AJ. Patterns of abuse among unintentional pharmaceutical overdose fatalities. JAMA. 2008; 300 ( 22 ): 2613 - 2620. doi: 10.1001/jama.2008.802
dc.identifier.citedreferenceSun EC, Dixit A, Humphreys K, Darnall BD, Baker LC, Mackey S. Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis. BMJ. Published online March 14, 2017. j760. doi: 10.1136/bmj.j760
dc.identifier.citedreferenceJena AB, Goldman D, Weaver L, Karaca-Mandic P. Opioid prescribing by multiple providers in Medicare: retrospective observational study of insurance claims. BMJ. 2014; 348: g1393. doi: 10.1136/bmj.g1393
dc.identifier.citedreferenceKaiser Family Foundation. Opioid Overdose Deaths by Race/Ethnicity. Opioid Overdose Deaths by Race/Ethnicity (1999-2018). 2020. https://www.kff.org/other/state-indicator/opioid-overdose-deaths-by-raceethnicity
dc.identifier.citedreferenceAlexander MJ, Kiang MV, Barbieri M. Trends in Black and White opioid mortality in the United States, 1979–2015. Epidemiology. 2018; 29 ( 5 ): 707 - 715. doi: 10.1097/EDE.0000000000000858
dc.identifier.citedreferenceMeghani SH, Byun E, Gallagher RM. Time to take stock: a meta-analysis and systematic review of analgesic treatment disparities for pain in the United States. Pain Med. 2012; 13: 150 - 174.
dc.identifier.citedreferenceHarrison JM, Lagisetty P, Sites BD, Guo C, Davis MA. Trends in prescription pain medication use by race/ethnicity among US adults with noncancer pain, 2000–2015. Am J Public Health. 2018; 108 ( 6 ): 788 - 790. doi: 10.2105/AJPH.2018.304349
dc.identifier.citedreferencePearson SA, Soumerai S, Mah C, et al. Racial disparities in access after regulatory surveillance of benzodiazepines. Arch Intern Med. 2006; 166 ( 5 ): 572 - 579. doi: 10.1001/archinte.166.5.572
dc.identifier.citedreferenceRoss-Degnan D, Simoni-Wastila L, Brown JS, et al. A controlled study of the effects of state surveillance on indicators of problematic and non-problematic benzodiazepine use in a Medicaid population. Int J Psychiatry Med. 2004; 34 ( 2 ): 103 - 123. doi: 10.2190/8FR4-QYY1-7MYG-2AGJ
dc.identifier.citedreferenceHaffajee RL. Prescription drug monitoring programs—friend or folly in addressing the opioid-overdose crisis? N Engl J Med. 2019; 381 ( 8 ): 699 - 701. doi: 10.1056/NEJMp1904714
dc.identifier.citedreferenceTemple University Beasley School of Law. Prescription Drug Abuse Policy System (PDAPS); 2020. http://pdaps.org
dc.identifier.citedreferenceCenters for Disease and Prevention Office for Tribal, Local, and Territorial Support. Menu of Pain Management Clinic Regulation; 2012:7. https://www.cdc.gov/phlp/docs/menu-pmcr.pdf
dc.identifier.citedreferenceFrizzell LC, Vuolo M, Kelly BC. State pain management clinic policies and county opioid prescribing: a fixed effects analysis. Drug Alcohol Depend. 2020; 216: 108239. doi: 10.1016/j.drugalcdep.2020.108239
dc.identifier.citedreferenceLiang D, Shi Y. The association between pain clinic laws and prescription opioid exposures: new evidence from multi-state comparisons. Drug Alcohol Depend. 2020; 206: 107754. doi: 10.1016/j.drugalcdep.2019.107754
dc.identifier.citedreferenceSinghal A, Tien YY, Hsia RY. Racial-ethnic disparities in opioid prescriptions at emergency department visits for conditions commonly associated with prescription drug abuse. PLoS One. 2016; 11 ( 8 ): e0159224. doi: 10.1371/journal.pone.0159224
dc.identifier.citedreferenceGaither JR, Gordon K, Crystal S, et al. Racial disparities in discontinuation of long-term opioid therapy following illicit drug use among black and white patients. Drug Alcohol Depend. 2018; 192: 371 - 376. doi: 10.1016/j.drugalcdep.2018.05.033
dc.identifier.citedreferenceBuonora M, Perez HR, Heo M, Cunningham CO, Starrels JL. Race and gender are associated with opioid dose reduction among patients on chronic opioid therapy. Pain Med. Published online July 18, 2018. doi: 10.1093/pm/pny137
dc.identifier.citedreferenceBecker WC, Starrels JL, Heo M, Li X, Weiner MG, Turner BJ. Racial differences in primary care opioid risk reduction strategies. Ann Fam Med. 2011; 9 ( 3 ): 219 - 225. doi: 10.1370/afm.1242
dc.identifier.citedreferenceWilson N, Kariisa M, Seth P, Iv HS, Davis NL. Drug and opioid-involved overdose deaths – United States, 2017–2018. MMWR Morb Mortal Wkly Rep. 2020; 69 ( 11 ): 8 - 297.
dc.identifier.citedreferenceBohnert ASB, Valenstein M, Bair MJ, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. 2011; 305 ( 13 ): 7.
dc.identifier.citedreferencePaulozzi LJ. Prescription drug overdoses: a review. J Safety Res. 2012; 43 ( 4 ): 283 - 289. doi: 10.1016/j.jsr.2012.08.009
dc.identifier.citedreferenceCenters for Disease Control, and Prevention. 2019 Annual Surveillance Report of Drug-Related Risks and Outcomes—United States Surveillance Special Report. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services; 2019:128. Accessed December 11, 2021. www.cdc.gov/drugoverdose/pdf/pubs/2019-cdc-drug-surveillancereport.pdf
dc.identifier.citedreferenceHan B, Compton WM, Blanco C, Crane E, Lee J, Jones CM. Prescription opioid use, misuse, and use disorders in U.S. adults: 2015 National Survey on Drug Use and Health. Ann Intern Med. Published online 2017. 10.
dc.identifier.citedreferenceSchuler MS, Schell TL, Wong EC. Racial/ethnic differences in prescription opioid misuse and heroin use among a national sample, 1999-2018. Drug Alcohol Depend. Published online February 2021. 108588. doi: 10.1016/j.drugalcdep.2021.108588
dc.identifier.citedreferenceShavers VL, Bakos A, Sheppard VB. Race, ethnicity, and pain among the U.S. adult population. J Health Care Poor Underserved. 2010; 21 ( 1 ): 177 - 220. doi: 10.1353/hpu.0.0255
dc.identifier.citedreferenceHoffman KM, Trawalter S, Axt JR, Oliver MN. Racial bias in pain assessment and treatment recommendations, and false beliefs about biological differences between blacks and whites. Proc Natl Acad Sci U S A. 2016; 113 ( 16 ): 4296 - 4301. doi: 10.1073/pnas.1516047113
dc.identifier.citedreferenceFrakt A, Monkovic T. A ‘rare case where racial biases’ protected African-Americans. The New York Times. Published December 2, 2019. https://www.nytimes.com/2019/11/25/upshot/opioid-epidemic-blacks.html
dc.identifier.citedreferenceAnderson KO, Green CR, Payne R. Racial and ethnic disparities in pain: causes and consequences of unequal care. J Pain. 2009; 10 ( 12 ): 1187 - 1204. doi: 10.1016/j.jpain.2009.10.002
dc.identifier.citedreferenceBenkert R, Peters RM, Clark R, Keves-Foster K. Effects of perceived racism, cultural mistrust and trust in providers on satisfaction with care. J Natl Med Assoc. 2006; 98 ( 9 ): 1532 - 1540.
dc.identifier.citedreferenceWilliams DR, Mohammed SA. Discrimination and racial disparities in health: evidence and needed research. J Behav Med. 2009; 32 ( 1 ): 20 - 47. doi: 10.1007/s10865-008-9185-0
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.