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Pain and functional disability amongst adults with moderate and severe haemophilia from the Irish personalised approach to the treatment of haemophilia (iPATH) study

dc.contributor.authorKennedy, Megan
dc.contributor.authorO’ Mahony, Brian
dc.contributor.authorRoche, Sheila
dc.contributor.authorMcGowan, Mark
dc.contributor.authorSingleton, Evelyn
dc.contributor.authorRyan, Kevin
dc.contributor.authorO’ Connell, Niamh M.
dc.contributor.authorPipe, Steven W.
dc.contributor.authorLavin, Michelle
dc.contributor.authorO’ Donnell, James S.
dc.contributor.authorTurecek, Peter L.
dc.contributor.authorGormley, John
dc.date.accessioned2022-06-01T20:30:22Z
dc.date.available2023-07-01 16:30:21en
dc.date.available2022-06-01T20:30:22Z
dc.date.issued2022-06
dc.identifier.citationKennedy, Megan; O’ Mahony, Brian ; Roche, Sheila; McGowan, Mark; Singleton, Evelyn; Ryan, Kevin; O’ Connell, Niamh M. ; Pipe, Steven W.; Lavin, Michelle; O’ Donnell, James S. ; Turecek, Peter L.; Gormley, John (2022). "Pain and functional disability amongst adults with moderate and severe haemophilia from the Irish personalised approach to the treatment of haemophilia (iPATH) study." European Journal of Haematology (6): 518-527.
dc.identifier.issn0902-4441
dc.identifier.issn1600-0609
dc.identifier.urihttps://hdl.handle.net/2027.42/172836
dc.description.abstractObjectivesTo establish the prevalence of pain and functional disability in Irish adults with moderate and severe haemophilia, and to examine demographic and lifestyle influences.MethodsMales ≥18 years with moderate or severe haemophilia participated. Pain and function were examined using the PROBE questionnaire.ResultsOf 49 participants [median age 44 (IQR 32, 52) years], most had severe haemophilia (Factor VIII = 30; Factor IX = 13) and were on regular prophylaxis (88%). Those with moderate haemophilia (Factor VIII = 5; Factor IX = 1) treated on demand (12%). Acute (72%) and chronic pain (71%), functional difficulties (58%), and analgesic requirements (92%) were prevalent. Age was significantly associated with more advanced haemophilic arthropathy (p = .002), chronic pain (p = .029) and functional difficulties (p = .036). Adults who reported chronic pain commenced prophylaxis significantly later in life [32 (20, 51) vs. 8 (1, 23) years; p = .004]. Physical activity was significantly lower in those with functional difficulties (p < .05). A disparity between self-perceived ‘target joints’ and clinically defined target joints was also identified (76% vs. 23%).ConclusionHaemophilic arthropathy, pain and functional disability were prevalent amongst Irish adults with moderate and severe haemophilia. Age-dependent lifestyle, analgesic and treatment influences on pain and function warrant further investigation.
dc.publisherWorld Federation of Hemophilia
dc.publisherWiley Periodicals, Inc.
dc.subject.otherpain
dc.subject.otherfunction
dc.subject.otherhaemophilia
dc.subject.otherphysical activity
dc.subject.otherprophylaxis
dc.titlePain and functional disability amongst adults with moderate and severe haemophilia from the Irish personalised approach to the treatment of haemophilia (iPATH) study
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOncology and Hematology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172836/1/ejh13763.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172836/2/ejh13763_am.pdf
dc.identifier.doi10.1111/ejh.13763
dc.identifier.sourceEuropean Journal of Haematology
dc.identifier.citedreferenceHilliard P, Funk S, Zourikian N, et al. Hemophilia joint health score reliability study. Haemophilia. 2006; 12 ( 5 ): 518 - 525.
dc.identifier.citedreferenceGouw SC, Timmer MA, Srivastava A, et al. Measurement of joint health in persons with haemophilia: a systematic review of the measurement properties of haemophilia-specific instruments. Haemophilia. 2019; 25 ( 1 ): e1 - e10.
dc.identifier.citedreferenceSkinner MW, Chai-Adisaksopha C, Curtis R, et al. The patient reported outcomes, burdens and experiences (PROBE) project: development and evaluation of a questionnaire assessing patient reported outcomes in people with haemophilia. Pilot Feasibility Study. 2018; 4 ( 1 ): 58.
dc.identifier.citedreferenceChai-Adisaksopha C, Skinner MW, Curtis R, et al. Psychometric properties of the patient reported outcomes, burdens and experiences (PROBE) questionnaire. BMJ Open. 2018; 8 ( 8 ): e021900.
dc.identifier.citedreferenceChai-Adisaksopha C, Skinner MW, Curtis R, et al. Test-retest properties of the patient reported outcomes, burdens and experiences (PROBE) questionnaire and its constituent domains. Haemophilia. 2019; 25 ( 1 ): 75 - 83.
dc.identifier.citedreferenceBlanchette VS, Key NS, Ljung LR, et al. Definitions in hemophilia: communication from the SSC of the ISTH. J Thromb Haemost. 2014; 12 ( 11 ): 1935 - 1939.
dc.identifier.citedreferenceBull FC, Al-Ansari SS, Biddle S, et al. World health organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020; 54 ( 24 ): 1451.
dc.identifier.citedreferenceKelly LA, McMillan DG, Anderson A, Fippinger M, Fillerup G, Rider J. Validity of actigraphs uniaxial and triaxial accelerometers for assessment of physical activity in adults in laboratory conditions. BMC Med Phys. 2013; 13 ( 1 ): 5.
dc.identifier.citedreferenceAadland E, Ylvisåker E. Reliability of the actigraph GT3X+ accelerometer in adults under free-living conditions. PLoS One. 2015; 10 ( 8 ): e0134606.
dc.identifier.citedreferenceMigueles JH, Cadenas-Sanchez C, Ekelund U, et al. Accelerometer data collection and processing criteria to assess physical activity and other outcomes: a systematic review and practical considerations. Sports Med. 2017; 47 ( 9 ): 1821 - 1845.
dc.identifier.citedreferenceTroiano RP, Berrigan D, Dodd KW, M-sse LC, Tilert T, McDowell M. Physical activity in the United States measured by accelerometer. Med Sci Sports Exerc. 2008; 40 ( 1 ): 181 - 188.
dc.identifier.citedreferenceWHO. Body mass index - BMI. World Health Organisation Regional Office for Europe. https://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi. Accessed February 23, 2022.
dc.identifier.citedreferenceKempton CL, Recht M, Neff A, et al. Impact of pain and functional impairment in US adults with haemophilia: patient-reported outcomes and musculoskeletal evaluation in the pain, functional impairment and quality of life (P-FiQ) study. Haemophilia. 2018; 24 ( 2 ): 261 - 270.
dc.identifier.citedreferenceLorenzato CS, Santos RB, Fagundes GZZ, Ozelo MC. Haemophilia experiences, results and opportunities (HERO study) in Brazil: assessment of the psychosocial effects of haemophilia in patients and caregivers. Haemophilia. 2019; 25 ( 4 ): 640 - 650.
dc.identifier.citedreferenceBreivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006; 10 ( 4 ): 287 - 333.
dc.identifier.citedreferenceRaftery MN, Sarma K, Murphy AW, De la Harpe D, Normand C, McGuire BE. Chronic pain in the Republic of Ireland—Community prevalence, psychosocial profile and predictors of pain-related disability: results from the prevalence, impact and cost of chronic pain (PRIME) study, part 1. Pain. 2011; 152 ( 5 ): 1096 - 1103.
dc.identifier.citedreferenceManco-Johnson MJ, Lundin B, Funk S, et al. Effect of late prophylaxis in hemophilia on joint status: a randomized trial. J Thromb Haemost. 2017; 15 ( 11 ): 2115 - 2124.
dc.identifier.citedreferenceManco-Johnson MJ, Soucie JM, Gill JC. Prophylaxis usage, bleeding rates, and joint outcomes of hemophilia, 1999 to 2010: a surveillance project. Blood. 2017; 129 ( 17 ): 2368 - 2374.
dc.identifier.citedreferenceWallny T, Lahaye L, Brackmann HH, Heß L, Seuser A, Kraft CN. Clinical and radiographic scores in haemophilic arthropathies: how well do these correlate to subjective pain status and daily activities? Haemophilia. 2002; 8 ( 6 ): 802 - 808.
dc.identifier.citedreferenceWang K, Kim HA, Felson DT, et al. Radiographic knee osteoarthritis and knee pain: cross-sectional study from five different racial/ethnic populations. Sci Rep. 2018; 8 ( 1 ): 1364.
dc.identifier.citedreferenceFelson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med. 2000; 133 ( 8 ): 635 - 646.
dc.identifier.citedreferenceAuerswald G, Dolan G, Duffy A, et al. Pain and pain management in haemophilia. Blood Coagul Fibrinolysis. 2016; 27 ( 8 ): 845 - 854.
dc.identifier.citedreferenceArachchillage DRJ, Makris M. Choosing and using non-steroidal anti-inflammatory drugs in haemophilia. Haemophilia. 2016; 22 ( 2 ): 179 - 187.
dc.identifier.citedreferenceGeneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH. Physical activity and exercise for chronic pain in adults: an overview of cochrane reviews. Cochrane Database Syst Rev. 2017; 4: CD011279.
dc.identifier.citedreferenceSanta Mina D, Clarke H, Ritvo P, et al. Effect of total-body prehabilitation on postoperative outcomes: a systematic review and meta-analysis. Physiotherapy. 2014; 100 ( 3 ): 196 - 207.
dc.identifier.citedreferenceTimmer MA, Veenhof C, de Kleijn P, de Bie RA, Schutgens REG, Pisters MF. Movement behaviour patterns in adults with haemophilia. Ther Adv Hematol. 2020; 11: 2040620719896959.
dc.identifier.citedreferenceMcLaughlin P, Hurley M, Chowdary P, Khair K, Stephensen D. Physiotherapy interventions for pain management in haemophilia: a systematic review. Haemophilia. 2020; 26 ( 4 ): 667 - 684.
dc.identifier.citedreferenceArranz L-I, Rafecas M, Alegre C. Effects of obesity on function and quality of life in chronic pain conditions. Curr Rheumatol Rep. 2013; 16 ( 1 ): 390.
dc.identifier.citedreferenceDaïen CI, Sellam J. Obesity and inflammatory arthritis: impact on occurrence, disease characteristics and therapeutic response. RMD Open. 2015; 1 ( 1 ): e000012.
dc.identifier.citedreferenceAjeganova S, Andersson ML, Hafström I, Group, f.t.B.S. Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities: a long-term followup from disease onset. Arthritis Care Res (Hoboken). 2013; 65 ( 1 ): 78 - 87.
dc.identifier.citedreferenceDepartment of Health/Ipsos MRBI, Healthy Ireland 2015 Survey Summary of Findings. Department of Health, 2015. https://assets.gov.ie/16210/525a06d3aaef4f23889c8fbdcc40d40a.pdf. Accessed February 22, 2022.
dc.identifier.citedreferenceJanke EA, Collins A, Kozak AT. Overview of the relationship between pain and obesity: what do we know? Where do we go next? J Rehabil Res Dev. 2007; 44 ( 2 ): 245 - 262.
dc.identifier.citedreferenceGleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011; 11 ( 9 ): 607 - 615.
dc.identifier.citedreferenceRaffini L, Manno C. Modern management of haemophilic arthropathy. Br J Haematol. 2007; 136 ( 6 ): 777 - 787.
dc.identifier.citedreferenceFranchini M, Mannucci PM. Modifiers of clinical phenotype in severe congenital hemophilia. Thromb Res. 2017; 156: 60 - 64.
dc.identifier.citedreferenceMannucci PM, Tuddenham EG. The hemophilias–from royal genes to gene therapy. N Engl J Med. 2001; 344 ( 23 ): 1773 - 1779.
dc.identifier.citedreferenceSrivastava A, Santagostino E, Dougall A, et al. Guidelines for the management of hemophilia. Haemophilia. 2020; 26 ( S6 ): 1 - 158.
dc.identifier.citedreferenceMancuso ME, Mahlangu JN, Pipe SW. The changing treatment landscape in haemophilia: from standard half-life clotting factor concentrates to gene editing. Lancet. 2021; 397 ( 10274 ): 630 - 640.
dc.identifier.citedreferenceWallny T, Hess L, Seuser A, Zander D, Brackmann HH, Kraft CN. Pain status of patients with severe haemophilic arthropathy. Haemophilia. 2001; 7 ( 5 ): 453 - 458.
dc.identifier.citedreferencevan Genderen FR, Fischer K, Heijnen L, et al. Pain and functional limitations in patients with severe haemophilia. Haemophilia. 2006; 12 ( 2 ): 147 - 153.
dc.identifier.citedreferenceSantavirta N, Solovieva S, Helkama O, Lehto S, Konttinen YT, Santavirta S. Musculoskeletal pain and functional ability in haemophilia A and B. Physiotherapy and rehabilitation in haemophilia patients. Rheumatol Int. 2001; 21 ( 1 ): 15 - 19.
dc.identifier.citedreferenceFlaherty LM, Schoeppe J, Kruse-Jarres R, Konkle BA. Balance, falls, and exercise: beliefs and experiences in people with hemophilia: a qualitative study. Res Pract Thromb Haemost. 2018; 2 ( 1 ): 147 - 154.
dc.identifier.citedreferenceGoodson NJ, Smith BH, Hocking LJ, et al. Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: results from a cross-sectional general population study. Pain. 2013; 154 ( 9 ): 1595 - 1602.
dc.identifier.citedreferenceWFH. World Federation of Hemophilia Report on the Annual Global Survey 2009. World Federation of Hemophilia; 2017.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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