Neurofibromatosis type 2 versus sporadic vestibular schwannoma: The utility of MR diffusion and dynamic contrast-enhanced imaging
dc.contributor.author | Ota, Yoshiaki | |
dc.contributor.author | Liao, Eric | |
dc.contributor.author | Capizzano, Aristides A. | |
dc.contributor.author | Baba, Akira | |
dc.contributor.author | Kurokawa, Ryo | |
dc.contributor.author | Kurokawa, Mariko | |
dc.contributor.author | Srinivasan, Ashok | |
dc.date.accessioned | 2022-06-01T20:31:22Z | |
dc.date.available | 2023-06-01 16:31:21 | en |
dc.date.available | 2022-06-01T20:31:22Z | |
dc.date.issued | 2022-05 | |
dc.identifier.citation | Ota, Yoshiaki; Liao, Eric; Capizzano, Aristides A.; Baba, Akira; Kurokawa, Ryo; Kurokawa, Mariko; Srinivasan, Ashok (2022). "Neurofibromatosis type 2 versus sporadic vestibular schwannoma: The utility of MR diffusion and dynamic contrast-enhanced imaging." Journal of Neuroimaging 32(3): 554-560. | |
dc.identifier.issn | 1051-2284 | |
dc.identifier.issn | 1552-6569 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/172857 | |
dc.description.abstract | Background and PurposeThe goal of this study was to assess the utility of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to distinguish sporadic vestibular schwannomas (VSs) from those related to neurofibromatosis type 2 (NF2).MethodsWe retrospectively reviewed 265 patients pathologically diagnosed with VSs between January 2015 and October 2020 in a single institution. There were 28 patients (male: 19, female: 9; age 11-67 years) including 23 sporadic and five NF2-related VSs, who had pretreatment DWI and DCE-MRI. Normalized mean apparent diffusion coefficient (nADCmean) and DCE-MRI parameters along with tumor characteristics were compared between sporadic and NF2-related VSs as appropriate. The diagnostic performances were calculated based on the receiver operating characteristic curve analysis for the values that showed significant differences. To identify significant modalities, multivariate logistic regression analysis was performed using nADCmean and the combination of statistically significant DCE-MRI parameters.ResultsNADCmean, fractional volume of extracellular space (Ve), and forward volume transfer constant (Ktrans) were significantly different between sporadic and NF2-related VSs (nADCmean: median 1.62 vs. 1.16, P�=�.002; Ve: median 0.40 vs. 0.66, P�=�.007; Ktrans: median 0.17 vs. 0.33, P�=�.007), whereas fractional plasma volume (Vp), reverse�reflux rate�constant (Kep), and tumor characteristics were not. The diagnostic performances of nADCmean, Ve, and Ktrans were 0.93, 0.90, and 0.90 area under the curves with cutoffs of 1.46, 0.51, and 0.29, respectively. nADCmean and the combination of Ve and Ktrans were both chosen as significant differentiators by multivariate logistic regression analysis (P�=�.027).ConclusionsDWI and DCE-MRI are both promising modalities to distinguish sporadic and NF2-related VSs. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | DWI | |
dc.subject.other | DCE-MRI | |
dc.subject.other | vestibular schwannoma | |
dc.title | Neurofibromatosis type 2 versus sporadic vestibular schwannoma: The utility of MR diffusion and dynamic contrast-enhanced imaging | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Neurosciences | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/172857/1/jon12966.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/172857/2/jon12966_am.pdf | |
dc.identifier.doi | 10.1111/jon.12966 | |
dc.identifier.source | Journal of Neuroimaging | |
dc.identifier.citedreference | Evans DG, King AT, Bowers NL, et�al. Identifying the deficiencies of current diagnostic criteria for neurofibromatosis 2 using databases of 2777 individuals with molecular testing. Genet Med 2019; 21: 1525 - 33. | |
dc.identifier.citedreference | Niknafs YS, Wang AC, Than KD, Etame AB, Thompson BG, Sullivan SE. Hemorrhagic vestibular schwannoma: review of the literature. World Neurosurg 2014; 82: 751 - 6. | |
dc.identifier.citedreference | Chen H, Xue Lu, Wang H, Wang Z, Wu H. Differential NF2 gene status in sporadic vestibular schwannomas and its prognostic impact on tumour growth patterns. Sci Rep 2017; 7: 5470. | |
dc.identifier.citedreference | Halliday J, Rutherford SA, Mccabe MG, Evans DG. An update on the diagnosis and treatment of vestibular schwannoma. Expert Rev Neurother 2018; 18: 29 - 39. | |
dc.identifier.citedreference | Coy S, Rashid R, Stemmer-Rachamimov A, Santagata S. An update on the CNS manifestations of neurofibromatosis type 2. Acta Neuropathol 2020; 139: 643 - 65. | |
dc.identifier.citedreference | Baser ME, Friedman JM, Joe H, Shenton A, Wallace AJ, Ramsden RT, Evans DGR. Empirical development of improved diagnostic criteria for neurofibromatosis 2. Genet Med 2011; 13: 576 - 81. | |
dc.identifier.citedreference | Skolnik AD, Loevner LA, Sampathu DM, et�al. Cranial nerve schwannomas: diagnostic imaging approach. Radiographics 2016; 36: 1463 - 77. | |
dc.identifier.citedreference | Plotkin SR, Duda DG, Muzikansky A, et�al. Multicenter, prospective, phase II and biomarker study of high-dose bevacizumab as induction therapy in patients with neurofibromatosis type 2 and progressive vestibular schwannoma. J Clin Oncol 2019; 37: 3446 - 54. | |
dc.identifier.citedreference | Sobel RA, Wang Y. Vestibular (acoustic) schwannomas: histologic features in neurofibromatosis 2 and in unilateral cases. J Neuropathol Exp Neurol 1993; 52: 106 - 13. | |
dc.identifier.citedreference | Evans GR, Lloyd SKW, Ramsden RT. Neurofibromatosis type 2. Adv Otorhinolaryngol 2011; 70: 91 - 8. | |
dc.identifier.citedreference | Gaddikeri S, Gaddikeri RS, Tailor T, Anzai Y. Dynamic contrast-enhanced MR imaging in head and neck cancer: techniques and clinical applications. AJNR Am J Neuroradiol 2016; 37: 588 - 95. | |
dc.identifier.citedreference | Ota Y, Liao E, Kurokawa R, et�al. Diffusion-weighted and dynamic contrast-enhanced MRI to assess radiation therapy response for head and neck paragangliomas. J Neuroimaging 2021; 31: 1035 - 43. | |
dc.identifier.citedreference | Ota Y, Naganawa S, Kurokawa R, et�al. Assessment of MR imaging and CT in differentiating hereditary and nonhereditary paragangliomas. AJNR Am J Neuroradiol 2021; 42: 1320 - 6. | |
dc.identifier.citedreference | Ota Y, Liao E, Capizzano AA, et�al. Diagnostic role of diffusion-weighted and dynamic contrast-enhanced perfusion MR imaging in paragangliomas and schwannomas in the head and neck. AJNR Am J Neuroradiol 2021; 42: 1839 - 46. | |
dc.identifier.citedreference | Huang N, Chen Yu, She D, Xing Z, Chen T, Cao D. Diffusion kurtosis imaging and dynamic contrast-enhanced MRI for the differentiation of parotid gland tumors. Eur Radiol 2021. https://doi.org/10.1007/s00330-021-08312-y | |
dc.identifier.citedreference | Hilton DA, Hanemann CO. Schwannomas and their pathogenesis. Brain Pathol 2014; 24: 205 - 20. | |
dc.identifier.citedreference | Lewis D, Donofrio CA, O’leary C, et�al. The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study. J Neurosurg 2020; 134: 1419 - 29. | |
dc.identifier.citedreference | Gehlhausen JR, Park Su-J, Hickox AE, et�al. A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation. Hum Mol Genet 2015; 24: 1 - 8. | |
dc.identifier.citedreference | Jung SC, Yeom JA, Kim J-H, et�al. Glioma: application of histogram analysis of pharmacokinetic parameters from T1-weighted dynamic contrast-enhanced MR imaging to tumor grading. AJNR Am J Neuroradiol 2014; 35: 1103 - 10. | |
dc.identifier.citedreference | Jia Z, Geng D, Xie T, Zhang J, Liu Y. Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging. J Clin Neurosci 2012; 19: 820 - 3. | |
dc.identifier.citedreference | Wong H-K, Shimizu A, Kirkpatrick ND, et�al. Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. Neoplasia 2012; 14: 84 - 94. | |
dc.identifier.citedreference | Lewis D, Roncaroli F, Agushi E, et�al. Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma. Neuro Oncol 2019; 21: 314 - 25. | |
dc.working.doi | NO | en |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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