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Regulation of the gonadotropin-releasing hormone neuron during stress
dc.contributor.authorMcCosh, Richard B.
dc.contributor.authorO’Bryne, Kevin T.
dc.contributor.authorKarsch, Fred J.
dc.contributor.authorBreen, Kellie M.
dc.date.accessioned2022-07-05T21:00:33Z
dc.date.available2023-06-05 17:00:32en
dc.date.available2022-07-05T21:00:33Z
dc.date.issued2022-05
dc.identifier.citationMcCosh, Richard B.; O’Bryne, Kevin T.; Karsch, Fred J.; Breen, Kellie M. (2022). "Regulation of the gonadotropin-releasing hormone neuron during stress." Journal of Neuroendocrinology (5): n/a-n/a.
dc.identifier.issn0953-8194
dc.identifier.issn1365-2826
dc.identifier.urihttps://hdl.handle.net/2027.42/172953
dc.description.abstractThe effect of stress on reproduction and gonadal function has captivated investigators for almost 100 years. Following the identification of gonadotropin-releasing hormone (GnRH) 50 years ago, a niche research field emerged fixated on how stress impairs this central node controlling downstream pituitary and gonadal function. It is now clear that both episodic GnRH secretion in males and females and surge GnRH secretion in females are inhibited during a variety of stress types. There has been considerable advancement in our understanding of numerous stress-related signaling molecules and their ability to impair reproductive neuroendocrine activity during stress. Recently, much attention has turned to the effects of stress on two populations of kisspeptin neurons: the stimulatory afferents to GnRH neurons that regulate pulsatile and surge-type gonadotropin secretion. Indeed, future work is still required to fully construct the neuroanatomical framework underlying stress effects, directly or indirectly, on GnRH neuron function. The present review evaluates and synthesizes evidence related to stress-related signaling molecules acting directly on GnRH neurons. Here, we review the evidence for and against the action of a handful of signaling molecules as inhibitors of GnRH neuron function, including corticotropin-releasing hormone, urocortins, norepinephrine, cortisol/corticosterone, calcitonin gene-related peptide and arginine-phenylalanine-amide-related peptide-3.The gonadotropin-releasing hormone (GnRH) neuron is central to the orchestration of reproductive biology inmalesandfemales and a node of inhibition inresponsetostress.This review evaluates the evidence for and against the action of a handful of stress-induced signaling molecules as inhibitors of GnRH neuron function, including corticotropin-releasing hormone, urocortins, norepinephrine, cortisol/corticosterone, calcitonin gene-related peptide, and arginine-phenylalanine-amide-related peptide-3.
dc.publisherElsevier
dc.publisherWiley Periodicals, Inc.
dc.subject.otherurocortins
dc.subject.othernorepinephrine
dc.subject.otherCGRP
dc.subject.othercorticosterone
dc.subject.othercortisol
dc.subject.otherCRH
dc.subject.otherGnRH
dc.subject.otherLH
dc.subject.otherRFRP-3
dc.subject.otherstress
dc.titleRegulation of the gonadotropin-releasing hormone neuron during stress
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172953/1/jne13098.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/172953/2/jne13098_am.pdf
dc.identifier.doi10.1111/jne.13098
dc.identifier.sourceJournal of Neuroendocrinology
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