View Item 

Show simple item record

Dimensional changes in free epithelialized gingival/mucosal grafts at tooth and implant sites: A prospective cohort study
dc.contributor.authorMonje, Alberto
dc.contributor.authorBlasi, Gonzalo
dc.contributor.authorAmerio, Ettore
dc.contributor.authorSanz-Martin, Ignacio
dc.contributor.authorNart, José
dc.date.accessioned2022-08-02T18:58:16Z
dc.date.available2023-08-02 14:58:14en
dc.date.available2022-08-02T18:58:16Z
dc.date.issued2022-07
dc.identifier.citationMonje, Alberto; Blasi, Gonzalo; Amerio, Ettore; Sanz-Martin, Ignacio ; Nart, José (2022). "Dimensional changes in free epithelialized gingival/mucosal grafts at tooth and implant sites: A prospective cohort study." Journal of Periodontology 93(7): 1014-1023.
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.urihttps://hdl.handle.net/2027.42/173126
dc.description.abstractBackgroundA study was made of the dimensional changes in free epithelialized gingival/mucosal grafts (FEGs) used to augment keratinized tissue (KT) at tooth and implant sites, and of the confounders influencing the dynamic changes over 6 months of follow-up.MethodsA prospective cohort interventional study was made of implant and tooth sites needing KT augmentation by means of an apically positioned flap and FEG. Six intraoperative variables were recorded at baseline (T0). In addition, graft width (GW), graft length (GL), and graft dimension (GD) were assessed at 3 weeks (T1), 3 months (T2), and 6 months of follow-up (T3). Univariate and multivariate analyses were performed to explore associations between the demographic and intraoperative variables and the outcomes over the study period.ResultsBased upon an a priori power sample size calculation, a total of 56 consecutive patients were recruited, of which 52 were available for assessment. A total of 73 graft units were included in 122 sites. At T3, the mean change in GD in FEG was 40.21%. In particular, the mean changes in GL and GW were 12.13% and 33.06%, respectively. Statistically significant changes in GD were recorded from T0 to T1 (P < 0.0005) and from T1 to T2 (P < 0.0005), but not from T2 to T3 (P = 0.13). The change in GD at T3 was 33.26% at tooth and 43.11% at implant site level (P = 0.01). Age and GW assessed at T0 proved to be related to the changes in GD and GW in the univariate and multivariate analyses. The univariate analysis showed the avascular area (AA) to be related to the changes in GD and GW at the implant sites, whereas graft thickness (GT) was associated to changes in GD and GW at the tooth sites in the univariate and multivariate analyses.ConclusionFree epithelialized grafts are exposed to dimensional changes that result in a reduction of approximately 40% of the original graft dimension–the changes being approximately 10% greater at the implant sites than at the tooth sites (NCT04410614).
dc.publisherWiley Periodicals, Inc.
dc.subject.othermucogingival surgery
dc.subject.otherconnective tissue graft(s)
dc.subject.otherimplantology
dc.titleDimensional changes in free epithelialized gingival/mucosal grafts at tooth and implant sites: A prospective cohort study
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/173126/1/jper10920_am.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/173126/2/jper10920.pdf
dc.identifier.doi10.1002/JPER.21-0521
dc.identifier.sourceJournal of Periodontology
dc.identifier.citedreferenceNabers JM. Extension of the vestibular fornix utilizing a gingival graft–case history. Periodontics. 1966; 4: 77 – 79.
dc.identifier.citedreferenceSullivan HC, Atkins JH. The role of free gingival grafts in periodontal therapy. Dent Clin North Am. 1969; 13: 133 – 148.
dc.identifier.citedreferenceMormann W, Schaer F, Firestone AR. The relationship between success of free gingival grafts and transplant thickness. Revascularization and shrinkage–a one year clinical study. J Periodontol. 1981; 52: 74 – 80.
dc.identifier.citedreferenceGumus P, Buduneli E. Graft stabilization with cyanoacrylate decreases shrinkage of free gingival grafts. Aust Dent J. 2014; 59: 57 – 64.
dc.identifier.citedreferenceKarakis Akcan S, Guler B, Hatipoglu H. The effect of different gingival phenotypes on dimensional stability of free gingival graft: a comparative 6-month clinical study. J Periodontol. 2019; 90: 709 – 717.
dc.identifier.citedreferenceSilva CO, Ribeiro Edel P, Sallum AW, Tatakis DN. Free gingival grafts: graft shrinkage and donor-site healing in smokers and non-smokers. J Periodontol. 2010; 81: 692 – 701.
dc.identifier.citedreferenceVon Elm E, Altman DG, Egger M, et al. The Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007; 147: 573 – 577.
dc.identifier.citedreferenceBerglundh T, Armitage G, Araujo MG, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 2018; 89: S313 – S318. Suppl 1.
dc.identifier.citedreferenceMonje A, Blasi G, Nart J, Urban IA, Nevins M, Wang HL. Soft tissue conditioning for the surgical therapy of peri-implantitis: a prospective 12-month study. Int J Periodons Restorat Dent. 2020; 40: 899 – 906.
dc.identifier.citedreferenceOchsenbein C, Maynard JG. The problem of attached gingiva in children. ASDC J Dent Child. 1974; 41: 263 – 272.
dc.identifier.citedreferenceHolbrook T, Ochsenbein C. Complete coverage of the denuded root surface with a one-stage gingival graft. Int J Periodonts Restor Dent. 1983; 3: 8 – 27.
dc.identifier.citedreferencePennel BM, Tabor JC, King KO, Towner JD, Fritz BD, Higgason JD. Free masticatory mucosa graft. J Periodontol. 1969; 40: 162 – 166.
dc.identifier.citedreferenceNabers JM. Free gingival grafts. Periodontics. 1966; 4: 243 – 245.
dc.identifier.citedreferenceMormann W, Bernimoulin JP, Schmid MO. Fluorescein angiography of free gingival autografts. J Clin Periodontol. 1975; 2: 177 – 189.
dc.identifier.citedreferenceCaffesse RG, Burgett FG, Nasjleti CE, Castelli WA. Healing of free gingival grafts with and without periosteum. Part I. Histologic evaluation. J Periodontol. 1979; 50: 586 – 594.
dc.identifier.citedreferenceHatipoglu H, Keceli HG, Guncu GN, Sengun D, Tozum TF. Vertical and horizontal dimensional evaluation of free gingival grafts in the anterior mandible: a case report series. Clin Oral Investig. 2007; 11: 107 – 113.
dc.identifier.citedreferenceSchmitt CM, Tudor C, Kiener K, et al. Vestibuloplasty: porcine collagen matrix versus free gingival graft: a clinical and histologic study. J Periodontol. 2013; 84: 914 – 923.
dc.identifier.citedreferenceMiller PD Jr. Root coverage with the free gingival graft. Factors associated with incomplete coverage. J Periodontol. 1987; 58: 674 – 681.
dc.identifier.citedreferenceRateitschak KH, Egli U, Fringeli G. Recession: a 4-year longitudinal study after free gingival grafts. J Clin Periodontol. 1979; 6: 158 – 164.
dc.identifier.citedreferenceJames WC. Placement of free gingival grafts on denuded alveolar bone. Part I: clinical evaluations. J Periodontol. 1978; 49: 283 – 290.
dc.identifier.citedreferenceSchmitt CM, Moest T, Lutz R, Wehrhan F, Neukam FW, Schlegel KA. Long-term outcomes after vestibuloplasty with a porcine collagen matrix (Mucograft((R))) versus the free gingival graft: a comparative prospective clinical trial. Clin Oral Implants Res. 2016; 27: e125 – e133.
dc.identifier.citedreferenceParvini P, Galarraga-Vinueza ME, Obreja K, Magini RS, Sader R, Schwarz F. Prospective study assessing three-dimensional changes of mucosal healing following soft tissue augmentation using free gingival grafts. J Periodontol. 2021; 92: 400 – 408.
dc.identifier.citedreferenceOliver RC, Loe H, Karring T. Microscopic evaluation of the healing and revascularization of free gingival grafts. J Periodontal Res. 1968; 3: 84 – 95.
dc.identifier.citedreferenceWennstrom JL, Bengazi F, Lekholm U. The influence of the masticatory mucosa on the peri-implant soft tissue condition. Clin Oral Implants Res. 1994; 5: 1 – 8.
dc.identifier.citedreferenceWennstrom JL. Lack of association between width of attached gingiva and development of soft tissue recession. A 5-year longitudinal study. J Clin Periodontol. 1987; 14: 181 – 184.
dc.identifier.citedreferenceWarrer K, Buser D, Lang NP, Karring T. Plaque-induced peri-implantitis in the presence or absence of keratinized mucosa. An experimental study in monkeys. Clin Oral Implants Res. 1995; 6: 131 – 138.
dc.identifier.citedreferenceBengazi F, Botticelli D, Favero V, Perini A, Urbizo Velez J, Lang NP. Influence of presence or absence of keratinized mucosa on the alveolar bony crest level as it relates to different buccal marginal bone thicknesses. An experimental study in dogs. Clin Oral Implants Res. 2014; 25: 1065 – 1071.
dc.identifier.citedreferenceStetler KJ, Bissada NF. Significance of the width of keratinized gingiva on the periodontal status of teeth with submarginal restorations. J Periodontol. 1987; 58: 696 – 700.
dc.identifier.citedreferenceMonje A, Blasi G. Significance of keratinized mucosa/gingiva on peri-implant and adjacent periodontal conditions in erratic maintenance compliers. J Periodontol. 2019; 90: 445 – 453.
dc.identifier.citedreferenceLang NP, BartoldPM. Periodontal health. J Periodontol. 2018; 89: S9 – S16. Suppl 1.
dc.identifier.citedreferenceAraujo MG, Lindhe J. Peri-implant health. J Periodontol. 2018; 89: S249 – S256. Suppl 1.
dc.identifier.citedreferenceUeno D, Nagano T, Watanabe T, Shirakawa S, Yashima A, Gomi K. Effect of the keratinized mucosa width on the health status of periimplant and contralateral periodontal tissues: a cross-sectional study. Implant Dent. 2016; 25: 796 – 801.
dc.identifier.citedreferenceZigdon H, Machtei EE. The dimensions of keratinized mucosa around implants affect clinical and immunological parameters. Clin Oral Implants Res. 2008; 19: 387 – 392.
dc.identifier.citedreferenceBoynuegri D, Nemli SK, Kasko YA. Significance of keratinized mucosa around dental implants: a prospective comparative study. Clin Oral Implants Res. 2013; 24: 928 – 933.
dc.identifier.citedreferenceTavelli L, Barootchi S, Avila-Ortiz G, Urban IA, Giannobile WV, Wang HL. Peri-implant soft tissue phenotype modification and its impact on peri-implant health: a systematic review and network meta-analysis. J Periodontol. 2021; 92: 21 – 44.
dc.identifier.citedreferenceAgudio G, Cortellini P, Buti J, Pini Prato G. Periodontal conditions of sites treated with gingival augmentation surgery compared with untreated contralateral homologous sites: an 18- to 35-Year long-term study. J Periodontol. 2016; 87: 1371 – 1378.
dc.identifier.citedreferenceThoma DS, Lim HC, Paeng KW, et al. Augmentation of keratinized tissue at tooth and implant sites by using autogenous grafts and collagen-based soft-tissue substitutes. J Clin Periodontol. 2020; 47: 64 – 71.
dc.identifier.citedreferenceRaoofi S, Asadinejad SM, Khorshidi H. Evaluation of color and width of attached gingiva gain in two surgical techniques: free gingival graft and connective tissue graft covered by thin mucosal flap, a clinical trial. J Dent (Shiraz). 2019; 20: 224 – 231.
dc.identifier.citedreferenceAgudio G, Nieri M, Rotundo R, Cortellini P, Pini Prato G. Free gingival grafts to increase keratinized tissue: a retrospective long-term evaluation (10 to 25 years) of outcomes. J Periodontol. 2008; 79: 587 – 594.
dc.identifier.citedreferenceGolmayo P, Barallat L, Losada M, Valles C, Nart J, Pascual-La Rocca A. Keratinized tissue gain after free gingival graft augmentation procedures around teeth and dental implants: a prospective observational study. J Clin Periodontol. 2021; 48: 302 – 314.
dc.identifier.citedreferenceSullivan HC, Atkins JH. Free autogenous gingival grafts. I. Principles of successful grafting. Periodontics. 1968; 6: 121 – 129.
dc.working.doiNOen
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
jper10920_am.pdf
Size:
752.6KB
Format:
PDF
View/Open
Name:
jper10920.pdf
Size:
4.698MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.