Metabolic abnormalities, liver and body fat in American versus Chinese patients with non-alcoholic fatty liver disease
dc.contributor.author | Zhang, Wei | |
dc.contributor.author | Su, Grace L | |
dc.contributor.author | Sravanthi, Kaza | |
dc.contributor.author | Huang, Rui | |
dc.contributor.author | Wang, Yi | |
dc.contributor.author | Rao, Huiying | |
dc.contributor.author | Wei, Lai | |
dc.contributor.author | Lok, Anna S | |
dc.date.accessioned | 2022-08-02T18:58:56Z | |
dc.date.available | 2023-09-02 14:58:55 | en |
dc.date.available | 2022-08-02T18:58:56Z | |
dc.date.issued | 2022-08 | |
dc.identifier.citation | Zhang, Wei; Su, Grace L; Sravanthi, Kaza; Huang, Rui; Wang, Yi; Rao, Huiying; Wei, Lai; Lok, Anna S (2022). "Metabolic abnormalities, liver and body fat in American versus Chinese patients with non-alcoholic fatty liver disease." JGH Open 6(8): 519-530. | |
dc.identifier.issn | 2397-9070 | |
dc.identifier.issn | 2397-9070 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/173140 | |
dc.description.abstract | Background and AimNon-alcoholic fatty liver disease (NAFLD) is common in the United States and China. We compared prevalence of metabolic syndrome (MS), hepatic steatosis and fibrosis, and quantity and quality of body fat between American versus Chinese patients with NAFLD.MethodsNAFLD patients were prospectively recruited from the University of Michigan Health System (UMHS) in the United States and Peking University Health Sciences Center (PUHSC) in China. All patients had baseline computed tomography (CT), laboratory tests and Fibroscan® controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Comparisons were made for overall cohorts and matched cohorts (matched for sex, age, and body mass index [BMI] category). Logistic regression was performed to identify independent predictors of moderate and severe steatosis and lack of advanced fibrosis.ResultsOne-hundred and one American and One-hundred and sixty Chinese patients were included. UMHS patients were older, with higher prevalence of MS, had higher LSM and CAP scores, and more fat in liver, visceral, subcutaneous, and muscle compartments than PUHSC patients. Differences in LSM, visceral fat Hounsfield unit, and subcutaneous fat area (SFA) persisted in the matched cohort. NAFLD patients with MS had significantly higher LSM, and more fat in liver, visceral, subcutaneous and muscle compartments than those without. Moderate or severe steatosis was independently associated with MS, visceral fat quality, and SFA, while the absence of advanced fibrosis was associated with Asian race and not having MS.ConclusionAmerican patients with NAFLD had more liver fibrosis than Chinese patients despite having better quality visceral fat and after matching for age, sex, and BMI category.One-hundred and one American (University of Michigan Health System) and one-hundred and sixty Chinese (Peking University Health Sciences Center) patients with non-alcoholic fatty liver disease were included in this study and 64 in each cohort were matched for sex, age, and body mass index category. | |
dc.publisher | Wiley Publishing Asia Pty Ltd | |
dc.subject.other | hepatic steatosis | |
dc.subject.other | metabolic syndrome | |
dc.subject.other | hepatic fibrosis | |
dc.subject.other | fatty liver disease | |
dc.subject.other | visceral adiposity | |
dc.title | Metabolic abnormalities, liver and body fat in American versus Chinese patients with non-alcoholic fatty liver disease | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/173140/1/jgh312756_am.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/173140/2/jgh312756.pdf | |
dc.identifier.doi | 10.1002/jgh3.12756 | |
dc.identifier.source | JGH Open | |
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dc.working.doi | NO | en |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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