Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage
dc.contributor.author | Okita, Yoshiki | |
dc.contributor.author | Koi, Minoru | |
dc.contributor.author | Takeda, Koki | |
dc.contributor.author | Ross, Ryan | |
dc.contributor.author | Mukherjee, Bhramar | |
dc.contributor.author | Koeppe, Erika | |
dc.contributor.author | Stoffel, Elena M. | |
dc.contributor.author | Galanko, Joseph A. | |
dc.contributor.author | McCoy, Amber N. | |
dc.contributor.author | Keku, Temitope O. | |
dc.contributor.author | Okugawa, Yoshinaga | |
dc.contributor.author | Kitajima, Takahito | |
dc.contributor.author | Toiyama, Yuji | |
dc.contributor.author | Martens, Eric | |
dc.contributor.author | Carethers, John M. | |
dc.date.accessioned | 2022-08-10T18:21:59Z | |
dc.date.available | 2022-08-10T18:21:59Z | |
dc.date.issued | 2020-09-29 | |
dc.identifier.citation | Gut Pathogens. 2020 Sep 29;12(1):46 | |
dc.identifier.uri | https://doi.org/10.1186/s13099-020-00384-3 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/173691 | en |
dc.description.abstract | Abstract Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP). Fn infection is also associated with the inflammatory tumor microenvironment of CRC. A subtype of CRC exhibits inflammation-associated microsatellite alterations (IAMA), which are characterized by microsatellite instability-low (MSI-L) and/or an elevated level of microsatellite alterations at selected tetra-nucleotide repeats (EMAST). Here we describe two independent CRC cohorts in which heavy or moderate loads of Fn DNA are associated with MSI-H and L/E CRC respectively. We also show evidence that Fn produces factors that induce γ-H2AX, a hallmark of DNA double strand breaks (DSBs), in the infected cells. | |
dc.title | Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage | |
dc.type | Article | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/173691/1/13099_2020_Article_384.pdf | |
dc.identifier.doi | https://dx.doi.org/10.7302/5422 | |
dc.language.rfc3066 | en | |
dc.rights.holder | The Author(s) | |
dc.date.updated | 2022-08-10T18:21:58Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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