Activation of G protein-coupled estradiol receptor 1 in the dorsolateral striatum enhances motivation for cocaine and drug-induced reinstatement in female but not male rats
dc.contributor.author | Quigley, Jacqueline A. | |
dc.contributor.author | Logsdon, Molly K. | |
dc.contributor.author | Graham, Brianna C. | |
dc.contributor.author | Beaudoin, Kendra G. | |
dc.contributor.author | Becker, Jill B. | |
dc.date.accessioned | 2022-08-10T18:43:22Z | |
dc.date.available | 2022-08-10T18:43:22Z | |
dc.date.issued | 2021-08-14 | |
dc.identifier.citation | Biology of Sex Differences. 2021 Aug 14;12(1):46 | |
dc.identifier.uri | https://doi.org/10.1186/s13293-021-00389-w | |
dc.identifier.uri | https://hdl.handle.net/2027.42/173935 | en |
dc.description.abstract | Abstract Background Estradiol potentiates drug-taking behaviors, including motivation to self-administer cocaine and reinstatement of drug-seeking after extinction in females, but not males. The dorsolateral stratum (DLS) is a region of the brain implicated in mediating drug-seeking behaviors and, more specifically, is a target brain area to study how estradiol regulates these behaviors. The estradiol receptors α, β, and G protein-coupled estradiol receptor 1 (GPER1) are all present in the DLS. In this study, the effects of activating GPER1 in the DLS on drug-seeking are investigated. Methods Gonad-intact male and female rats were trained to self-administer cocaine (0.4 mg/kg/inf) on a fixed-ratio 1 schedule of reinforcement. For 4 weeks, animals underwent testing on a progressive ratio schedule of reinforcement to determine their motivation to attain cocaine. Halfway through progressive ratio testing, a selective agonist targeting GPER1 (G1) was administered intra-DLS to determine the contribution of GPER1 activation on motivation for cocaine. The effects of intra-DLS GPER1 activation on drug-induced reinstatement after extinction were subsequently determined. Results Activation of GPER1, via intra-DLS G1 administration, potentiated females’ motivation to self-administer cocaine. There was no effect of prior G1 treatment on extinction of cocaine-taking in females; however, G1 treatment resulted in greater drug-induced reinstatement (10 mg/kg cocaine, i.p.). There were no effects of intra-DLS GPER1 activation observed on motivation for cocaine or cocaine-induced reinstatement of responding in males. Conclusions These results support the conclusion that activation of GPER1 in the DLS enhances cocaine-seeking behaviors for female, but not male rats. | |
dc.title | Activation of G protein-coupled estradiol receptor 1 in the dorsolateral striatum enhances motivation for cocaine and drug-induced reinstatement in female but not male rats | |
dc.type | Journal Article | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/173935/1/13293_2021_Article_389.pdf | |
dc.identifier.doi | https://dx.doi.org/10.7302/5666 | |
dc.language.rfc3066 | en | |
dc.rights.holder | The Author(s) | |
dc.date.updated | 2022-08-10T18:43:22Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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