Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19
dc.contributor.author | Carenzo, Luca | |
dc.contributor.author | Protti, Alessandro | |
dc.contributor.author | Dalla Corte, Francesca | |
dc.contributor.author | Aceto, Romina | |
dc.contributor.author | Iapichino, Giacomo | |
dc.contributor.author | Milani, Angelo | |
dc.contributor.author | Santini, Alessandro | |
dc.contributor.author | Chiurazzi, Chiara | |
dc.contributor.author | Ferrari, Michele | |
dc.contributor.author | Heffler, Enrico | |
dc.contributor.author | Angelini, Claudio | |
dc.contributor.author | Aghemo, Alessio | |
dc.contributor.author | Ciccarelli, Michele | |
dc.contributor.author | Chiti, Arturo | |
dc.contributor.author | Iwashyna, Theodore J. | |
dc.contributor.author | Herridge, Margaret S. | |
dc.contributor.author | Cecconi, Maurizio | |
dc.date.accessioned | 2022-08-10T18:43:26Z | |
dc.date.available | 2022-08-10T18:43:26Z | |
dc.date.issued | 2021-06-04 | |
dc.identifier.citation | Annals of Intensive Care. 2021 Jun 04;11(1):91 | |
dc.identifier.uri | https://doi.org/10.1186/s13613-021-00881-x | |
dc.identifier.uri | https://hdl.handle.net/2027.42/173936 | en |
dc.description.abstract | Abstract Background Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability after ICU and hospital discharge. The subsequent social burden is a major concern. We aimed to assess the short-term HRQoL, physical function and prevalence of post-traumatic stress symptoms of invasively mechanically ventilated COVID-19 patients treated in our ICU. Methods Prospective, observational cohort study in a follow-up clinic. Patients completed a 6-min walking test (6MWT) to assess their cardio-pulmonary function around 2 months (early follow-up) from hospital discharge, the EQ-5D-5L questionnaire for quality of life assessment around 2 months and at 6 months from hospital discharge and an anonymous web-based Impact of Event Scale-Revised (IES-R) questionnaire for Post-Traumatic Stress symptoms at 2 months. Results 47 patients attended our follow-up program, mean age 59 ± 10 years, median pre-morbid Clinical Frailty Scale (CFS) 2 [2–3]. The median distance walked in 6 min was 470 [406–516] m, 83 [67–99]% of the predicted value. Overall 1 out 3 patients and 4/18 (22%) among those with a good functional baseline prior to COVID-19 (CFS of 1 or 2) had lower (84%) than predicted 6MWT. EQ-5D-5L quality of life VAS was 80 [70–90] out of 100 at early follow-up with a slight improvement to 85 [77.5–90] at 6 months. Mobility, self-care and usual activities improved between the two timepoints, while pain/discomfort and depression/anxiety did not improve or got worse. The IES-R total score was greater than the threshold for concern of 1.6 in 27/41(66%) respondents. Conclusions Patients recovering from severe COVID-19 requiring invasive mechanical ventilation surviving hospital discharge present with early mild to moderate functional impairment, mildly reduced quality of life from hospital discharge with an overall improvement of mobility, self-care and the ability of performing usual activities, while a worsening of pain and depression/anxiety symptoms at 6 months and a large proportion of symptoms of post-traumatic distress soon after hospital discharge. | |
dc.title | Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19 | |
dc.type | Journal Article | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/173936/1/13613_2021_Article_881.pdf | |
dc.identifier.doi | https://dx.doi.org/10.7302/5667 | |
dc.language.rfc3066 | en | |
dc.rights.holder | The Author(s) | |
dc.date.updated | 2022-08-10T18:43:26Z | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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